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2024 | OriginalPaper | Chapter

A Multi-order Adaptive Network Model for Pathways of DNA Methylation and Its Effects in Individuals Developing Post-traumatic Stress Disorder

Authors : Iva Gunjača, Natalie Samhan, Jan Treur

Published in: Complex Networks & Their Applications XII

Publisher: Springer Nature Switzerland

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Abstract

In this paper, an integrative fifth-order biological and mental network model is introduced, to demonstrate epigenetics effects in Post-Traumatic Stress Disorder (PTSD), using an adaptive network modeling approach based on temporal-casual networks. The network model assesses DNA methylation dysregulation, on glucocorticoid receptors, and side effects of glucocorticoid receptor hyperreactivity to glucocorticoids in fear processing of individuals with post-traumatic stress disorder. Furthermore, a form of therapy is explored on differently methylated genes. Genes NR3C1 and FKBP5, and their expression were chosen for the demonstration, furthermore, administering MDMA was chosen as a form of therapy. Several simulations were run to analyze and illustrate behavior of the network model. Behaviors for both genes and their expression were tested together and individually.

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Title: A Multi-order Adaptive Network Model for Pathways of DNA Methylation and Its Effects in Individuals Developing Post-traumatic Stress Disorder
Authors: Iva Gunjača
Natalie Samhan
Jan Treur
Publisher: Springer Nature Switzerland
Book: Complex Networks & Their Applications XII
Print ISBN: 978-3-031-53498-0

Electronic ISBN: 978-3-031-53499-7

Copyright Year: 2024
DOI: https://doi.org/10.1007/978-3-031-53499-7_34

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