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Medical & Biological Engineering & Computing

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07-11-2018 | Original Article

A novel technique with reduced computed tomography exposure to predict vertebral compression fracture: a finite element study based on rat vertebrae

Authors: Giovanni F. Solitro, Florian Mainnemare, Farid Amirouche, Ankit Mehta

Published in: Medical & Biological Engineering & Computing | Issue 4/2019

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Abstract

Vertebral compression fractures are a significant clinical issue with an annual incidence of approximately 750,000 cases in the USA alone. Mechanical properties of vertebrae are successfully evaluated through finite element (FE) models based on vertebrae CT. However, clinical drawbacks associated to radiation transmission encouraged to explore the possibility to use selected or reduced portions of the vertebra. The objective of our study was to develop a new procedure to predict vertebral compression fracture from sub-volumes. We reconstructed rat vertebras from micro-CT of thoracic and lumbar groups. Each vertebra was partitioned into three sub-volumes of different axial thickness. FE simulating compression tests were performed on each model to evaluate their failure load and stiffness. Using a power function, a high correlation was found for stiffness and strength. The sub-volume with three fifths thickness had a failure load of 180.7 ± 19.2 N for thoracic and of 209.5 ± 27.4 N for the lumbar vertebra. These values were not significantly different from the values found for the entire vertebra (p > 0.05). Based on our findings, failure loads and stiffnesses obtained with reduced CT scans can be successfully used to predict full vertebral failure. This sub-region analysis and power relationship suggests that one can limit radiation exposure to patients when bone characterization is needed.

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Balooch G, Yao W, Ager JW, Balooch M, Nalla RK, Porter AE, Ritchie RO, Lane NE (2007) The aminobisphosphonate risedronate preserves localized mineral and material properties of bone in the presence of glucocorticoids. Arthritis Rheum 56:3726–3737. https://doi.org/10.1002/art.22976 CrossRefPubMed

Blanchard R, Dejaco A, Bongaers E, Hellmich C (2013) Intravoxel bone micromechanics for microCT-based finite element simulations. J Biomech 46:2710–2721. https://doi.org/10.1016/j.jbiomech.2013.06.036 CrossRefPubMed

Bouxsein ML, Seeman E (2009) Quantifying the material and structural determinants of bone strength. Best Pract Res Clin Rheumatol 23:741–753. https://doi.org/10.1016/j.berh.2009.09.008 CrossRefPubMed

Boyd SK, Szabo E, Ammann P (2011) Increased bone strength is associated with improved bone microarchitecture in intact female rats treated with strontium ranelate: a finite element analysis study. Bone 48:1109–1116. https://doi.org/10.1016/j.bone.2011.01.004 CrossRefPubMed

Brenner DJ, Elliston CD (2004) Estimated radiation risks potentially associated with full-body CT screening. Radiology 232:735–738. https://doi.org/10.1148/radiol.2323031095

Brixen K, Chapurlat R, Cheung AM, Keaveny TM, Fuerst T, Engelke K, Recker R, Dardzinski B, Verbruggen N, Ather S, Rosenberg E, De Papp AE (2013) Bone density, turnover, and estimated strength in postmenopausal women treated with odanacatib: a randomized trial. J Clin Endocrinol Metab 98:571–580. https://doi.org/10.1210/jc.2012-2972 CrossRefPubMed

Brouwers JEM, Lambers FM, Van Rietbergen B, Ito K, Huiskes R (2009) Comparison of bone loss induced by ovariectomy and neurectomy in rats analyzed by in vivo micro-CT. J Orthop Res 27:1521–1527. https://doi.org/10.1002/jor.20913 CrossRefPubMed

Burkhart TA, Andrews DM, Dunning CE (2013) Finite element modeling mesh quality, energy balance and validation methods: a review with recommendations associated with the modeling of bone tissue. J Biomech 46:1477–1488. https://doi.org/10.1016/j.jbiomech.2013.03.022 CrossRefPubMed

Chevalier Y, Pahr D, Zysset PK (2009) The role of cortical shell and trabecular fabric in finite element analysis of the human vertebral body. J Biomech Eng 131:111003. https://doi.org/10.1115/1.3212097 CrossRefPubMed

10.

Colloca M, Blanchard R, Hellmich C, Ito K, van Rietbergen B (2014) A multiscale analytical approach for bone remodeling simulations: linking scales from collagen to trabeculae. Bone 64:303–313. https://doi.org/10.1016/j.bone.2014.03.050 CrossRefPubMed

11.

Crawford RP, Cann CE, Keaveny TM (2003) Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography. Bone 33:744–750. https://doi.org/10.1016/S8756-3282(03)00210-2 CrossRefPubMed

12.

Crawley EO, Evans WD, Owen GM (1988) A theoretical analysis of the accuracy of single-energy CT bone-mineral measurements. Phys Med 33:1113–1127. https://doi.org/10.1088/0031-9155/33/10/002 CrossRef

13.

Dall’Ara E, Karl C, Mazza G, Franzoso G, Vena P, Pretterklieber M, Pahr D, Zysset P (2013) Tissue properties of the human vertebral body sub-structures evaluated by means of microindentation. J Mech Behav Biomed Mater 25:23–32. https://doi.org/10.1016/j.jmbbm.2013.04.020 CrossRefPubMed

14.

Diamant I, Shahar R, Masharawi Y, Gefen A (2007) A method for patient-specific evaluation of vertebral cancellous bone strength: in vitro validation. Clin Biomech 22:282–291. https://doi.org/10.1016/j.clinbiomech.2006.10.005 CrossRef

15.

Easley SK, Jekir MG, Burghardt AJ, Li M, Keaveny TM (2009) Contribution of the intra-specimen variations in tissue mineralization to PTH- and raloxifene-induced changes in stiffness of rat vertebrae. Bone 46:1162–1169. https://doi.org/10.1016/j.bone.2009.12.009 CrossRefPubMed

16.

Giambini H, Qin X, Dragomir-Daescu D, An K-N, Nassr A (2015) Specimen-specific vertebral fracture modeling: a feasibility study using the extended finite element method. Med Biol Eng Comput 54:583–593. https://doi.org/10.1007/s11517-015-1348-x CrossRefPubMedPubMedCentral

17.

Hausleiter J, Meyer T, Hermann F (2009) Estimated radiation dose associated with cardiac CT angiography. Jama 301

18.

Hellmich C, Kober C, Erdmann B (2008) Micromechanics-based conversion of CT data into anisotropic elasticity tensors, applied to FE simulations of a mandible. Ann Biomed Eng 36:108–122. https://doi.org/10.1007/s10439-007-9393-8 CrossRefPubMed

19.

Henninger HB, Reese SP, Anderson a E, Weiss J a (2010) Validation of computational models in biomechanics. Proc Inst Mech Eng H 224:801–812. https://doi.org/10.1243/09544119JEIM649 CrossRefPubMedPubMedCentral

20.

Imai K, Ohnishi I, Yamamoto S, Nakamura K (2008) In vivo assessment of lumbar vertebral strength in elderly women using computed tomography-based nonlinear finite element model. Spine (Phila. Pa 1976) (33):27–32. https://doi.org/10.1097/BRS.0b013e31815e3993

21.

Ito M, Akifumi A, Ae N, Aoyagi K, Uetani M, Kuniaki A, Ae H, Kawase M (2005) Effects of risedronate on trabecular microstructure and biomechanical properties in ovariectomized rat tibia. doi:https://doi.org/10.1007/s00198-004-1802-3

22.

Ito M, Nakayama K, Konaka A, Sakata K, Ikeda K, Maruyama T (2006) Effects of a prostaglandin EP4 agonist, ONO-4819, and risedronate on trabecular microstructure and bone strength in mature ovariectomized rats. Bone 39:453–459. https://doi.org/10.1016/j.bone.2006.02.054 CrossRefPubMed

23.

Johnell O, Kanis JA (2004) An estimate of the worldwide prevalence, mortality and disability associated with hip fracture. Osteoporos Int 15:897–902. https://doi.org/10.1007/s00198-004-1627-0 CrossRefPubMed

24.

Kinney JH, Haupt DL, Balooch M, Ladd AJC, Ryaby JT, Lane NE (2000) Three-dimensional morphometry of the L6 vertebra in the ovariectomized rat model of osteoporosis: biomechanical implications. J Bone Miner Res 15:1981–1991. https://doi.org/10.1359/jbmr.2000.15.10.1981 CrossRefPubMed

25.

Kuefner MA, Grudzenski S, Hamann J, Achenbach S, Lell M, Anders K, Schwab SA, Häberle L, Löbrich M, Uder M (2010) Effect of CT scan protocols on x-ray-induced DNA double-strand breaks in blood lymphocytes of patients undergoing coronary CT angiography. Eur Radiol 20:2917–2924. https://doi.org/10.1007/s00330-010-1873-9 CrossRefPubMed

26.

Ladd AJC, Kinney JH (1998) Numerical errors and uncertainties in finite-element modeling of trabecular bone. J Biomech 31:941–945. https://doi.org/10.1016/S0021-9290(98)00108-0 CrossRefPubMed

27.

Lane NE, Yao W, Balooch M, Nalla RK, Balooch G, Habelitz S, Kinney JH, Bonewald LF (2005) Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res 21:466–476. https://doi.org/10.1359/JBMR.051103 CrossRefPubMedPubMedCentral

28.

Li H, Zhang H, Tang Z, Hu G (2008) Micro-computed tomography for small animal imaging: technological details. Prog Nat Sci 18:513–521. https://doi.org/10.1016/j.pnsc.2008.01.002 CrossRef

29.

Linet MS, Slovis TL, Miller DL, Kleinerman R, Lee C, Rajaraman P, Gonzalez AB De 2012 Cancer Risks Associated With External Radiation From Diagnostic Imaging Procedures 62, 75–100. doi:https://doi.org/10.3322/caac.21132

30.

Mazess RB, Barden HS, Drinka PJ, Bauwens SF, Orwoll ES, Bell NH (1990) Influence of age and body weight on spine and femur bone mineral density in U.S white men. J Bone Miner Res 5:645–652. https://doi.org/10.1002/jbmr.5650050614 CrossRefPubMed

31.

McNamara LM, Ederveen AGH, Lyons CG, Price C, Schaffler MB, Weinans H, Prendergast PJ (2006) Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing. Bone 39:392–400. https://doi.org/10.1016/j.bone.2006.02.070 CrossRefPubMed

32.

Melton LJ, Kallmes DF (2006) Epidemiology of vertebral fractures: implications for vertebral augmentation. Acad Radiol 13:538–545. https://doi.org/10.1016/j.acra.2006.01.005 CrossRefPubMed

33.

Müller R, Kampschulte M, El Khassawna T, Schlewitz G, Hürter B, Böcker W, Bobeth M, Langheinrich AC, Heiss C, Deutsch A, Cuniberti G (2014) Change of mechanical vertebrae properties due to progressive osteoporosis: combined biomechanical and finite-element analysis within a rat model. Med. Biol. Eng. Comput. 52:405–414. https://doi.org/10.1007/s11517-014-1140-3 CrossRefPubMed

34.

Notomi T, Okimoto N, Okazaki Y, Nakamura T, Suzuki M (2003) Tower climbing exercise started 3 months after ovariectomy recovers bone strength of the femur and lumbar vertebrae in aged osteopenic rats. J Bone Miner Res 18:140–149. https://doi.org/10.1359/jbmr.2003.18.1.140 CrossRefPubMed

35.

Nyman JS, Uppuganti S, Makowski AJ, Rowland BJ, Merkel AR, Sterling JA, Bredbenner TL, Perrien DS (2015) Predicting mouse vertebra strength with micro-computed tomography-derived finite element analysis. BoneKEy Rep 4:664. https://doi.org/10.1038/bonekey.2015.31 CrossRefPubMedPubMedCentral

36.

Perrien DS, Akel NS, Edwards PK, Carver AA, Bendre MS, Swain FL, Skinner RA, Hogue WR, Nicks KM, Pierson TM, Suva LJ, Gaddy D (2007) Inhibin A Is an Endocrine Stimulator of Bone Mass and Strength. Endocrinology 148(4):1654–1665. doi:https://doi.org/10.1210/en.2006-0848

37.

Pistoia W, van Rietbergen B, Lochmüller E-M, Lill CA, Eckstein F, Rüegsegger P (2002) Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 30:842–848. https://doi.org/10.1016/S8756-3282(02)00736-6 CrossRefPubMed

38.

Rincón-Kohli L, Zysset PK (2009) Multi-axial mechanical properties of human trabecular bone. Biomech Model Mechanobiol 8:195–208. https://doi.org/10.1007/s10237-008-0128-z CrossRefPubMed

39.

Shane E, Addesso V, Namerow PB, McMahon DJ, Lo S-H, Staron RB, Zucker M, Pardi S, Maybaum S, Mancini D (2004) Alendronate versus calcitriol for the prevention of bone loss after cardiac transplantation. N Engl J Med 350:767–776. https://doi.org/10.1056/NEJMoa035617 CrossRefPubMed

40.

Silverman SL (1992) The clinical consequences of vertebral compression fracture. Bone 13:S27–S31. https://doi.org/10.1016/9756-3282(92)90193-Z CrossRefPubMed

41.

Spatz JM, Ellman R, Cloutier AM, Louis L, Van Vliet M, Suva LJ, Dwyer D, Stolina M, Ke HZ, Bouxsein ML (2013) Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading. J Bone Miner Res 28:865–874. https://doi.org/10.1002/jbmr.1807 CrossRefPubMedPubMedCentral

42.

Thomsen JS, Niklassen AS, Ebbesen EN, Brüel A (2013) Age-related changes of vertical and horizontal lumbar vertebral trabecular 3D bone microstructure is different in women and men. Bone 57:47–55. https://doi.org/10.1016/j.bone.2013.07.025 CrossRefPubMed

43.

Verhulp E, van Rietbergen B, Müller R, Huiskes R (2008) Indirect determination of trabecular bone effective tissue failure properties using micro-finite element simulations. J Biomech 41:1479–1485. https://doi.org/10.1016/j.jbiomech.2008.02.032 CrossRefPubMed

44.

Vuong J, Hellmich C (2011) Bone fibrillogenesis and mineralization: quantitative analysis and implications for tissue elasticity. J Theor Biol 287:115–130. https://doi.org/10.1016/j.jtbi.2011.07.028 CrossRefPubMed

45.

Wagner DW, Lindsey DP, Beaupre GS (2011) Deriving tissue density and elastic modulus from microCT bone scans. Bone 49:931–938. https://doi.org/10.1016/j.bone.2011.07.021 CrossRefPubMed

46.

Wasnich RD (1996) Vertebral fracture epidemiology. Bone 18:179S–183SCrossRefPubMed

47.

Yao W, Cheng Z, Koester KJ, Ager JW, Balooch M, Pham A, Chefo S, Busse C, Ritchie RO, Lane NE (2007) The degree of bone mineralization is maintained with single intravenous bisphosphonates in aged estrogen-deficient rats and is a strong predictor of bone strength. Bone 41(5):804–812CrossRefPubMed

48.

Yeh JK, Aloia JF, Tierney JM, Sprintz S (2000) Effect of treadmill exercise on vertebral and Tibial bone mineral content and bone mineral density in the aged adult rat : determined by dual energy X-ray absorptiometry 234–238

49.

Zeinali A, Hashemi B, Akhlaghpoor S (2010) Noninvasive prediction of vertebral body compressive strength using nonlinear finite element method and an image based technique. Phys Medica 26:88–97. https://doi.org/10.1016/j.ejmp.2009.08.002 CrossRef

50.

Zioupos P, Currey J (1998) Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone 22:57–66. https://doi.org/10.1016/S8756-3282(97)00228-7 CrossRefPubMed

51.

Zysset P, Qin L, Lang T, Khosla S, Leslie WD, Shepherd JA, Schousboe JT, Engelke K (2015) Clinical use of quantitative computed tomography-based finite element analysis of the hip and spine in the management of osteoporosis in adults: the 2015 ISCD official positions-part II. J Clin Densitom 18:359–392. https://doi.org/10.1016/j.jocd.2015.06.011 CrossRefPubMed

Title: A novel technique with reduced computed tomography exposure to predict vertebral compression fracture: a finite element study based on rat vertebrae
Authors: Giovanni F. Solitro
Florian Mainnemare
Farid Amirouche
Ankit Mehta
Publication date: 07-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Medical & Biological Engineering & Computing / Issue 4/2019
Print ISSN: 0140-0118
Electronic ISSN: 1741-0444
DOI: https://doi.org/10.1007/s11517-018-1918-9

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