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Medical & Biological Engineering & Computing

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01-03-2010 | Original Article

A voxelized model of direct infusion into the corpus callosum and hippocampus of the rat brain: model development and parameter analysis

Authors: Jung Hwan Kim, Thomas H. Mareci, Malisa Sarntinoranont

Published in: Medical & Biological Engineering & Computing | Issue 3/2010

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Abstract

Recent experimental studies have shown convective-enhanced delivery (CED) to be useful for transporting macromolecular therapeutic agents over large tissue volumes in the central nervous system (CNS). There are limited tools currently available for predicting tissue distributions in the brain. We have developed a voxelized modeling methodology in which CNS tissues are modeled as porous media, and transport properties and anatomical boundaries are determined semi-automatically on a voxel-by-voxel basis using diffusion tensor imaging (DTI). By using this methodology, 3D extracellular transport models of the rat brain were developed. Macromolecular tracer distributions following CED in two different infusion sites (corpus callosum and hippocampus) were predicted. Sensitivity of models to changes in infusion parameters, transport properties, and modeling parameters was determined. Predicted tracer distributions were most sensitive to changes in segmentation threshold, DTI resolution, tissue porosity, and infusion site. This DTI-based voxelized modeling methodology provides a potentially rapid means of estimating CED transport.

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Title: A voxelized model of direct infusion into the corpus callosum and hippocampus of the rat brain: model development and parameter analysis
Authors: Jung Hwan Kim
Thomas H. Mareci
Malisa Sarntinoranont
Publication date: 01-03-2010
Publisher: Springer-Verlag
Published in: Medical & Biological Engineering & Computing / Issue 3/2010
Print ISSN: 0140-0118
Electronic ISSN: 1741-0444
DOI: https://doi.org/10.1007/s11517-009-0564-7

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