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Journal of Materials Science
Published in: Journal of Materials Science 18/2020

23-03-2020 | Materials for life sciences

Alginate@TiO2 hybrid microcapsules as a reservoir of beta INS-1E cells with controlled insulin delivery

Authors: Grégory Leroux, Myriam Neumann, Christophe F. Meunier, Carine Michiels, Li Wang, Bao-Lian Su

Published in: Journal of Materials Science | Issue 18/2020

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Abstract

Designing biocompatible materials to encapsulate xenogeneic insulin-releasing β-cells for transplantation has been considered as a promising alternative to avoid the immunosuppression and drawbacks of the treatment of Type 1 diabetes mellitus (T1D) by direct islet transplantation. The current work for the first time studied a hybrid alginate@TiO2 microcapsule as a reservoir for rat insulinoma-derived INS-1E cells, as a β-cell surrogate, towards the treatment of T1D. The hybrid microcapsule is composed of an alginate core as a biocompatible matrix for cell encapsulation and a crack-free TiO2 shell as a semipermeable membrane to prevent cell leakage, protect encapsulated cells from immune attacks, as well as allow the diffusion of nutrients and the secretion of insulin. Compared to most-commonly used pure alginate microcapsules, the insulin-secreting INS-1E cells encapsulated in our alginate@TiO2 microcapsules revealed higher metabolic activity and maintained the insulin secretion over more than 6 weeks. This study highlights that our designed alginate@TiO2 hybrid microcapsules can serve as an ideal reservoir for cell encapsulation towards the treatment of T1D, thus further promoting the development of artificial organs for cell therapy.
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Metadata
Title
Alginate@TiO2 hybrid microcapsules as a reservoir of beta INS-1E cells with controlled insulin delivery
Authors
Grégory Leroux
Myriam Neumann
Christophe F. Meunier
Carine Michiels
Li Wang
Bao-Lian Su
Publication date
23-03-2020
Publisher
Springer US
Published in
Journal of Materials Science / Issue 18/2020
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-020-04576-9

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