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2017 | OriginalPaper | Chapter

Altered PPI Due to Mutations in hPER2 and CKI Delta Locus, Causing ASPS

Authors : Ananya Ali, Angshuman Bagchi

Published in: Proceedings of the First International Conference on Intelligent Computing and Communication

Publisher: Springer Singapore

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Abstract

Protein-Protein Interactions (PPI) have a huge impact on several biological processes viz. enzyme substrate interaction, cell signaling to name a few. It is also well documented that altering PPI can also lead to onset of diseases. We have studied one circadian rhythm sleep disorder with genetic correlation viz. Familial Advanced Sleep Phase Syndrom (FASPS). In the present work, utilizing structural bioinformatics approach we tried to elucidate the differences in pattern of bindings between two different core “clock genes” products viz. human Period protein (hPER2) and human Casein Kinase I delta (hCKId), both in wild type and disease-causing mutated variants. Molecular mechanics calculations have also been used to describe the interactions of wild type and mutant proteins. The results from this study may be useful for the development of newer drugs in patients having impaired circadian rhythm.

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Title: Altered PPI Due to Mutations in hPER2 and CKI Delta Locus, Causing ASPS
Authors: Ananya Ali
Angshuman Bagchi
Publisher: Springer Singapore
Book: Proceedings of the First International Conference on Intelligent Computing and Communication
Print ISBN: 978-981-10-2034-6

Electronic ISBN: 978-981-10-2035-3

Copyright Year: 2017
DOI: https://doi.org/10.1007/978-981-10-2035-3_1

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