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Published in: Journal of Polymer Research 8/2023

01-08-2023 | Original Paper

Antibacterial wound dressings made of differently concentrated Salvia Miltiorrhiza Bunge via electrospinning

Authors: Tsan-Wen Huang, Minghuang Lin, Mei-Chen Lin, Ching-Wen Lou, Yueh-Sheng Chen, Jia-Horng Lin

Published in: Journal of Polymer Research | Issue 8/2023

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Abstract

This study is conducted with an attempt to explore the influences of PEO (2, 4, 6 wt%) and Salvia miltiorrhiza Bunge (100, 125, 150, and 175 mg/mL) over the antibacterial and other performances of wound dressings. The PEO/ Salvia miltiorrhiza Bunge mixtures are formed into wound dressings via the electrospinning. The scanning electron microscope (SEM) observation, fiber diameter analysis, water contact angle measurement, and antibacterial assay are performed to investigate the properties of wound dressings. The properties of nanofiber membranes are correlated with PEO concentration, and the antibacterial property of nanofiber membranes is dependent on the Salvia miltiorrhiza Bunge concentration, which makes the optimal Salvia miltiorrhiza Bunge/PEO ratio being 175/6. The optimal diameter of nanofibers is 239.00 ± 361 nm while the maximal diameter of inhibition zone is 11.50 mm. To sum up, the Salvia miltiorrhiza Bunge-loaded wound dressings exhibit the optimal water contact angle, antibacterial property, and nanofiber diameter.

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Literature
1.
go back to reference Liang Y, Liang Y, Zhang H, Guo B (2022) Antibacterial biomaterials for skin wound dressing. Asian J Pharm Sci Liang Y, Liang Y, Zhang H, Guo B (2022) Antibacterial biomaterials for skin wound dressing. Asian J Pharm Sci
2.
go back to reference Hashemikia S, Farhangpazhouh F, Parsa M, Hasan M, Hassanzadeh A, Hamidi M (2021) Fabrication of ciprofloxacin-loaded chitosan/polyethylene oxide/silica nanofibers for wound dressing application: in vitro and in vivo evaluations. Int J Pharm 597:120313CrossRefPubMed Hashemikia S, Farhangpazhouh F, Parsa M, Hasan M, Hassanzadeh A, Hamidi M (2021) Fabrication of ciprofloxacin-loaded chitosan/polyethylene oxide/silica nanofibers for wound dressing application: in vitro and in vivo evaluations. Int J Pharm 597:120313CrossRefPubMed
3.
go back to reference Yazarlu O, Iranshahi M, Kashani HRK, Reshadat S, Habtemariam S, Iranshahy M, Hasanpour M (2021) Perspective on the application of medicinal plants and natural products in wound healing: a mechanistic review. Pharmacol Res 174:105841CrossRefPubMed Yazarlu O, Iranshahi M, Kashani HRK, Reshadat S, Habtemariam S, Iranshahy M, Hasanpour M (2021) Perspective on the application of medicinal plants and natural products in wound healing: a mechanistic review. Pharmacol Res 174:105841CrossRefPubMed
4.
go back to reference Karizmeh MS, Poursamar SA, Kefayat A, Farahbakhsh Z, Rafienia M (2022) An in vitro and in vivo study of PCL/chitosan electrospun mat on polyurethane/propolis foam as a bilayer wound dressing. Biomaterials Adv 135:112667CrossRef Karizmeh MS, Poursamar SA, Kefayat A, Farahbakhsh Z, Rafienia M (2022) An in vitro and in vivo study of PCL/chitosan electrospun mat on polyurethane/propolis foam as a bilayer wound dressing. Biomaterials Adv 135:112667CrossRef
5.
go back to reference Naseri E, Ahmadi A (2022) A review on wound dressings: antimicrobial agents, biomaterials, fabrication techniques, and stimuli-responsive drug release. Eur Polymer J 111293 Naseri E, Ahmadi A (2022) A review on wound dressings: antimicrobial agents, biomaterials, fabrication techniques, and stimuli-responsive drug release. Eur Polymer J 111293
6.
go back to reference Adamu BF, Gao J, Jhatial AK, Kumelachew DM (2021) A review of medicinal plant-based bioactive electrospun nano fibrous wound dressings. Mater Design 209:109942CrossRef Adamu BF, Gao J, Jhatial AK, Kumelachew DM (2021) A review of medicinal plant-based bioactive electrospun nano fibrous wound dressings. Mater Design 209:109942CrossRef
7.
go back to reference Abadehie FS, Dehkordi AH, Zafari M, Bagheri M, Yousefiasl S, Pourmotabed S, Mahmoodnia L, Validi M, Ashrafizadeh M, Zare EN (2021) Lawsone-encapsulated chitosan/polyethylene oxide nanofibrous mat as a potential antibacterial biobased wound dressing. Eng Regeneration 2:219–226CrossRef Abadehie FS, Dehkordi AH, Zafari M, Bagheri M, Yousefiasl S, Pourmotabed S, Mahmoodnia L, Validi M, Ashrafizadeh M, Zare EN (2021) Lawsone-encapsulated chitosan/polyethylene oxide nanofibrous mat as a potential antibacterial biobased wound dressing. Eng Regeneration 2:219–226CrossRef
8.
go back to reference Chen G, Guo J, Nie J, Ma G (2016) Preparation, characterization, and application of PEO/HA core shell nanofibers based on electric field induced phase separation during electrospinning. Polymer 83:12–19CrossRef Chen G, Guo J, Nie J, Ma G (2016) Preparation, characterization, and application of PEO/HA core shell nanofibers based on electric field induced phase separation during electrospinning. Polymer 83:12–19CrossRef
9.
go back to reference Bharathi BS, Stalin T (2019) Cerium oxide and peppermint oil loaded polyethylene oxide/graphene oxide electrospun nanofibrous mats as antibacterial wound dressings. Mater Today Commun 21:100664CrossRef Bharathi BS, Stalin T (2019) Cerium oxide and peppermint oil loaded polyethylene oxide/graphene oxide electrospun nanofibrous mats as antibacterial wound dressings. Mater Today Commun 21:100664CrossRef
10.
go back to reference Saeed C, Qader A, Aziz S, Ricci PC (2022) Laser beam power attenuation characteristics for pure polyethylene oxide polymer with different thickness. Opt Mater 132:112815CrossRef Saeed C, Qader A, Aziz S, Ricci PC (2022) Laser beam power attenuation characteristics for pure polyethylene oxide polymer with different thickness. Opt Mater 132:112815CrossRef
11.
go back to reference Barba BJD, Aranilla CT, Relleve LS, Cruz VRC, Vista JR, Abad LV (2018) Hemostatic granules and dressing prepared from formulations of carboxymethyl cellulose, kappa-carrageenan and polyethylene oxide crosslinked by gamma radiation. Radiat Phys Chem 144:180–188CrossRef Barba BJD, Aranilla CT, Relleve LS, Cruz VRC, Vista JR, Abad LV (2018) Hemostatic granules and dressing prepared from formulations of carboxymethyl cellulose, kappa-carrageenan and polyethylene oxide crosslinked by gamma radiation. Radiat Phys Chem 144:180–188CrossRef
12.
go back to reference Parham S, Kharazi AZ (2022) Cellulosic textile/clove nanocomposite as an antimicrobial wound dressing: in vitro and in vivo study. Colloids Surf B 217:112659CrossRef Parham S, Kharazi AZ (2022) Cellulosic textile/clove nanocomposite as an antimicrobial wound dressing: in vitro and in vivo study. Colloids Surf B 217:112659CrossRef
13.
go back to reference Ou C, Jiang P, Tian Y, Yao Z, Yang Y, Peng J, Zeng M, Song H, Peng Q (2021) Fructus Lycii and Salvia miltiorrhiza Bunge extract alleviate retinitis pigmentosa through Nrf2/HO-1 signaling pathway. J Ethnopharmacol 273:113993CrossRefPubMed Ou C, Jiang P, Tian Y, Yao Z, Yang Y, Peng J, Zeng M, Song H, Peng Q (2021) Fructus Lycii and Salvia miltiorrhiza Bunge extract alleviate retinitis pigmentosa through Nrf2/HO-1 signaling pathway. J Ethnopharmacol 273:113993CrossRefPubMed
14.
go back to reference Pan M-H, Chiou Y-S, Tsai M-L, Ho C-T (2011) Anti-inflammatory activity of traditional chinese medicinal herbs. J Trad Complement Med 1:8–24CrossRef Pan M-H, Chiou Y-S, Tsai M-L, Ho C-T (2011) Anti-inflammatory activity of traditional chinese medicinal herbs. J Trad Complement Med 1:8–24CrossRef
15.
go back to reference Li H, Gao C, Liu C, Liu L, Zhuang J, Yang J, Zhou C, Feng F, Sun C, Wu J (2021) A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen. Biomed Pharmacother 137:111332CrossRefPubMed Li H, Gao C, Liu C, Liu L, Zhuang J, Yang J, Zhou C, Feng F, Sun C, Wu J (2021) A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen. Biomed Pharmacother 137:111332CrossRefPubMed
16.
go back to reference He S, Wang T, Shi C, Wang Z, Fu X (2022) Network pharmacology-based approach to understand the effect and mechanism of Danshen against anemia. J Ethnopharmacol 282:114615CrossRefPubMed He S, Wang T, Shi C, Wang Z, Fu X (2022) Network pharmacology-based approach to understand the effect and mechanism of Danshen against anemia. J Ethnopharmacol 282:114615CrossRefPubMed
18.
go back to reference Zhou J, Zhang L, Zheng B, Zhang L, Qin Y, Zhang X, Yang Z, Nie Z, Yang G, Yu J (2020) Salvia miltiorrhiza bunge exerts anti-oxidative effects through inhibiting KLF10 expression in vascular smooth muscle cells exposed to high glucose. J Ethnopharmacol 262:113208CrossRefPubMed Zhou J, Zhang L, Zheng B, Zhang L, Qin Y, Zhang X, Yang Z, Nie Z, Yang G, Yu J (2020) Salvia miltiorrhiza bunge exerts anti-oxidative effects through inhibiting KLF10 expression in vascular smooth muscle cells exposed to high glucose. J Ethnopharmacol 262:113208CrossRefPubMed
19.
go back to reference Yuen CW, Murugaiyah V, Najimudin N, Azzam G (2021) Danshen (Salvia miltiorrhiza) water extract shows potential neuroprotective effects in Caenorhabditis elegans. J Ethnopharmacol 266:113418CrossRefPubMed Yuen CW, Murugaiyah V, Najimudin N, Azzam G (2021) Danshen (Salvia miltiorrhiza) water extract shows potential neuroprotective effects in Caenorhabditis elegans. J Ethnopharmacol 266:113418CrossRefPubMed
20.
go back to reference Bu L, Dai O, Zhou F, Liu F, Chen J-F, Peng C, Xiong L (2020) Traditional chinese medicine formulas, extracts, and compounds promote angiogenesis. Biomed Pharmacother 132:110855CrossRefPubMed Bu L, Dai O, Zhou F, Liu F, Chen J-F, Peng C, Xiong L (2020) Traditional chinese medicine formulas, extracts, and compounds promote angiogenesis. Biomed Pharmacother 132:110855CrossRefPubMed
21.
go back to reference Mahalakshmi B, Huang C-Y, Lee S-D, Maurya N, Kumar VB (2021) Review of Danshen: from its metabolism to possible mechanisms of its biological activities. J Funct Foods 85:104613CrossRef Mahalakshmi B, Huang C-Y, Lee S-D, Maurya N, Kumar VB (2021) Review of Danshen: from its metabolism to possible mechanisms of its biological activities. J Funct Foods 85:104613CrossRef
22.
go back to reference Yu C, Dong H, Wang Q, Bai J, Li Y-N, Zhao J-J, Li J-Z (2021) Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother 142:111995CrossRefPubMed Yu C, Dong H, Wang Q, Bai J, Li Y-N, Zhao J-J, Li J-Z (2021) Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother 142:111995CrossRefPubMed
26.
go back to reference Chen K, Hu H, Zeng Y, Pan H, Wang S, Zhang Y, Shi L, Tan G, Pan W, Liu H (2022) Recent advances in electrospun nanofibers for wound dressing. Eur Polymer J 111490 Chen K, Hu H, Zeng Y, Pan H, Wang S, Zhang Y, Shi L, Tan G, Pan W, Liu H (2022) Recent advances in electrospun nanofibers for wound dressing. Eur Polymer J 111490
27.
go back to reference Geng H, Zhang P, Liu L, Shangguan Y, Cheng X, Liu H, Zhao Y, Hao J, Li W, Cui J (2022) Convergent architecting of multifunction-in-one hydrogels as wound dressings for surgical anti-infections. Mater Today Chem 25:100968CrossRef Geng H, Zhang P, Liu L, Shangguan Y, Cheng X, Liu H, Zhao Y, Hao J, Li W, Cui J (2022) Convergent architecting of multifunction-in-one hydrogels as wound dressings for surgical anti-infections. Mater Today Chem 25:100968CrossRef
28.
go back to reference Kharat Z, Goushki MA, Sarvian N, Asad S, Dehghan MM, Kabiri M (2021) Chitosan/PEO nanofibers containing Calendula officinalis extract: Preparation, characterization, in vitro and in vivo evaluation for wound healing applications. Int J Pharm 609:121132CrossRefPubMed Kharat Z, Goushki MA, Sarvian N, Asad S, Dehghan MM, Kabiri M (2021) Chitosan/PEO nanofibers containing Calendula officinalis extract: Preparation, characterization, in vitro and in vivo evaluation for wound healing applications. Int J Pharm 609:121132CrossRefPubMed
29.
go back to reference Bozkaya O, Arat E, Gök ZG, Yiğitoğlu M, Vargel I (2022) Production and characterization of hybrid nanofiber wound dressing containing Centella asiatica coated silver nanoparticles by mutual electrospinning method. Eur Polymer J 166:111023CrossRef Bozkaya O, Arat E, Gök ZG, Yiğitoğlu M, Vargel I (2022) Production and characterization of hybrid nanofiber wound dressing containing Centella asiatica coated silver nanoparticles by mutual electrospinning method. Eur Polymer J 166:111023CrossRef
30.
go back to reference Zhang K, Li Z, Kang W, Deng N, Yan J, Ju J, Liu Y, Cheng B (2018) Preparation and characterization of tree-like cellulose nanofiber membranes via the electrospinning method. Carbohydr Polym 183:62–69CrossRefPubMed Zhang K, Li Z, Kang W, Deng N, Yan J, Ju J, Liu Y, Cheng B (2018) Preparation and characterization of tree-like cellulose nanofiber membranes via the electrospinning method. Carbohydr Polym 183:62–69CrossRefPubMed
31.
go back to reference Vahabi H, Wu H, Saeb MR, Koo JH, Ramakrishna S (2021) Electrospinning for developing flame retardant polymer materials: current status and future perspectives. Polymer 217:123466CrossRef Vahabi H, Wu H, Saeb MR, Koo JH, Ramakrishna S (2021) Electrospinning for developing flame retardant polymer materials: current status and future perspectives. Polymer 217:123466CrossRef
32.
go back to reference Coelho SC, Estevinho BN, Rocha F (2021) Encapsulation in food industry with emerging electrohydrodynamic techniques: Electrospinning and electrospraying–A review. Food Chem 339:127850CrossRef Coelho SC, Estevinho BN, Rocha F (2021) Encapsulation in food industry with emerging electrohydrodynamic techniques: Electrospinning and electrospraying–A review. Food Chem 339:127850CrossRef
34.
go back to reference Wang A-M, Sha S-H, Lesniak W, Schacht J (2003) Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo. Antimicrob Agents Chemother 47:1836–1841CrossRefPubMedPubMedCentral Wang A-M, Sha S-H, Lesniak W, Schacht J (2003) Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo. Antimicrob Agents Chemother 47:1836–1841CrossRefPubMedPubMedCentral
35.
go back to reference Wu S, Zhao W, Sun M, He P, Lv H, Wang Q, Zhang S, Wu Q, Ling P, Chen S (2022) Novel bi-layered dressing patches constructed with radially-oriented nanofibrous pattern and herbal compound-loaded hydrogel for accelerated diabetic wound healing. Appl Mater Today 28:101542CrossRef Wu S, Zhao W, Sun M, He P, Lv H, Wang Q, Zhang S, Wu Q, Ling P, Chen S (2022) Novel bi-layered dressing patches constructed with radially-oriented nanofibrous pattern and herbal compound-loaded hydrogel for accelerated diabetic wound healing. Appl Mater Today 28:101542CrossRef
Metadata
Title
Antibacterial wound dressings made of differently concentrated Salvia Miltiorrhiza Bunge via electrospinning
Authors
Tsan-Wen Huang
Minghuang Lin
Mei-Chen Lin
Ching-Wen Lou
Yueh-Sheng Chen
Jia-Horng Lin
Publication date
01-08-2023
Publisher
Springer Netherlands
Published in
Journal of Polymer Research / Issue 8/2023
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-023-03649-y

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