Skip to main content
Top

2018 | OriginalPaper | Chapter

Automatic Segmentation of Corneal Endothelium Images with Convolutional Neural Network

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

A fully-automatic segmentation of corneal endothelial images is addressed in this paper. It can find its application in the medicine removing the burden of manual annotations from the physicians allowing for faster patient diagnosis. The proposed system is based on pre-trained convolutional neural network AlexNet and uses a transfer learning methodology to build a system for delineation of endothelial cells. The training is based on the classification of small patches of an image which represents cell body or cell border class. The validation set proved that 99% correct classification ratio accuracy and F1 score were achieved. Exploiting this network in a system configured for segmentation it proved very good detection of cell bodies and supported by best-fit skeletonization allowed to locate cell borders precisely.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literature
1.
go back to reference Agarwal, S., Agarwal, A., Apple, D., Buratto, L.: Textbook of Ophthalmology, vol. 2. Jaypee Brothers, Medical Publishers Ltd., New Dehli (2002) Agarwal, S., Agarwal, A., Apple, D., Buratto, L.: Textbook of Ophthalmology, vol. 2. Jaypee Brothers, Medical Publishers Ltd., New Dehli (2002)
2.
go back to reference Charlampowicz, K., Reska, D., Boldak, C.: Automatic segmentation of corneal endothelial cells using active contours. In: Advances in Computer Science Research, vol. 14, pp. 47–60 (2014) Charlampowicz, K., Reska, D., Boldak, C.: Automatic segmentation of corneal endothelial cells using active contours. In: Advances in Computer Science Research, vol. 14, pp. 47–60 (2014)
3.
go back to reference Dagher, I., El Tom, K.: Waterballoons: a hybrid watershed balloon snake segmentation. Image Vis. Comput. 26(7), 905–912 (2008)CrossRef Dagher, I., El Tom, K.: Waterballoons: a hybrid watershed balloon snake segmentation. Image Vis. Comput. 26(7), 905–912 (2008)CrossRef
4.
go back to reference Fabijanska, A.: Corneal endothelium image segmentation using feed forward neural network. In: 2017 Federated Conference on Computer Science and Information Systems (FedCSIS), pp. 629–637 (2017) Fabijanska, A.: Corneal endothelium image segmentation using feed forward neural network. In: 2017 Federated Conference on Computer Science and Information Systems (FedCSIS), pp. 629–637 (2017)
5.
go back to reference Foracchia, M., Ruggeri, A.: Corneal endothelium analysis by means of Bayesian shape modeling. In: Proceedings of the 25th Annual International Conference of the IEEE-EMBS, pp. 794–797. IEEE (2003) Foracchia, M., Ruggeri, A.: Corneal endothelium analysis by means of Bayesian shape modeling. In: Proceedings of the 25th Annual International Conference of the IEEE-EMBS, pp. 794–797. IEEE (2003)
7.
go back to reference Hoppenreijs, V., Pels, E., Vrensen, G., Treffers, W.: Corneal endothelium and growth factors. Surv. Ophthalmol. 41(2), 155–164 (1996)CrossRef Hoppenreijs, V., Pels, E., Vrensen, G., Treffers, W.: Corneal endothelium and growth factors. Surv. Ophthalmol. 41(2), 155–164 (1996)CrossRef
8.
go back to reference Katafuchi, S., Yoshimura, M.: Convolution neural network for contour extraction of corneal endothelial cells. Proc. SPIE 10338, 7 (2017) Katafuchi, S., Yoshimura, M.: Convolution neural network for contour extraction of corneal endothelial cells. Proc. SPIE 10338, 7 (2017)
9.
go back to reference Khan, M.A.U., Niazi, M.K.K., Khan, M.A., Ibrahim, M.T.: Endothelial cell image enhancement using non-subsampled image pyramid. Inf. Technol. J. 6(7), 1057–1062 (2007)CrossRef Khan, M.A.U., Niazi, M.K.K., Khan, M.A., Ibrahim, M.T.: Endothelial cell image enhancement using non-subsampled image pyramid. Inf. Technol. J. 6(7), 1057–1062 (2007)CrossRef
10.
go back to reference Krizhevsky, A., Sutskever, I., Hinton, G.E.: ImageNet classification with deep convolutional neural networks. In: Proceedings of the 25th International Conference on Neural Information Processing Systems, NIPS 2012, pp. 1097–1105. Curran Associates Inc., USA (2012) Krizhevsky, A., Sutskever, I., Hinton, G.E.: ImageNet classification with deep convolutional neural networks. In: Proceedings of the 25th International Conference on Neural Information Processing Systems, NIPS 2012, pp. 1097–1105. Curran Associates Inc., USA (2012)
11.
go back to reference Meyer, L., Ubels, J., Edelhauser, H.: Corneal endothelial morphology in the rat. Invest. Ophthalmol. Vis. Sci. 29(6), 940–949 (1988) Meyer, L., Ubels, J., Edelhauser, H.: Corneal endothelial morphology in the rat. Invest. Ophthalmol. Vis. Sci. 29(6), 940–949 (1988)
12.
go back to reference Nadachi, R., Nunokawa, K.: Automated corneal endothelial cell analysis. In: Proceedings of Fifth Annual IEEE Symposium on Computer-Based Medical Systems, pp. 450–457. IEEE (1992) Nadachi, R., Nunokawa, K.: Automated corneal endothelial cell analysis. In: Proceedings of Fifth Annual IEEE Symposium on Computer-Based Medical Systems, pp. 450–457. IEEE (1992)
15.
go back to reference Piorkowski, A., Nurzynska, K., Gronkowska-Serafin, J., Selig, B., Boldak, C., Reska, D.: Influence of applied corneal endothelium image segmentation techniques on the clinical parameters. Comput. Med. Imaging Graph. 55(Suppl. C), 13–27 (2017). Special Issue on Ophthalmic Medical Image AnalysisCrossRef Piorkowski, A., Nurzynska, K., Gronkowska-Serafin, J., Selig, B., Boldak, C., Reska, D.: Influence of applied corneal endothelium image segmentation techniques on the clinical parameters. Comput. Med. Imaging Graph. 55(Suppl. C), 13–27 (2017). Special Issue on Ophthalmic Medical Image AnalysisCrossRef
17.
go back to reference Ruggeri, A., Scarpa, F., De Luca, M., Meltendorf, C., Schroeter, J.: A system for the automatic estimation of morphometric parameters of corneal endothelium in alizarine red stained images. Br. J. Ophthalmol. 94(5), 643 (2010)CrossRef Ruggeri, A., Scarpa, F., De Luca, M., Meltendorf, C., Schroeter, J.: A system for the automatic estimation of morphometric parameters of corneal endothelium in alizarine red stained images. Br. J. Ophthalmol. 94(5), 643 (2010)CrossRef
19.
go back to reference Vincent, L.M., Masters, B.R.: Morphological image processing and network analysis of cornea endothelial cell images. In: San Diego 1992, vol. 1769, pp. 212–226. International Society for Optics and Photonics (1992) Vincent, L.M., Masters, B.R.: Morphological image processing and network analysis of cornea endothelial cell images. In: San Diego 1992, vol. 1769, pp. 212–226. International Society for Optics and Photonics (1992)
Metadata
Title
Automatic Segmentation of Corneal Endothelium Images with Convolutional Neural Network
Author
Karolina Nurzynska
Copyright Year
2018
DOI
https://doi.org/10.1007/978-3-319-99987-6_25

Premium Partner