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Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography Read chapter Read first chapter

2020 | OriginalPaper | Chapter

Balz-Schiemann Reaction

Authors : Chuanfa Ni, Bo Xing, Jinbo Hu

Published in: Fluorination

Publisher: Springer Singapore

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Excerpt

Aryl fluorides are important structural motifs in pharmaceuticals [1‐3], and nearly 20% of 200 best-selling drugs in 2018 contain at least one (hetero)aryl fluoride motif [4]. The past decade has witnessed significant progress in the development of aromatic C-F bond formation, especially via transition metal-mediated or catalyzed processes [5]. However, among all the available methods, Balz-Schiemann reaction (Scheme 1) is one of the most widely used methods for large-scale industrial production of aryl fluorides due to ready availability of the starting materials [6]. …

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Metadata
Title
Balz-Schiemann Reaction
Authors
Chuanfa Ni
Bo Xing
Jinbo Hu
Copyright Year
2020
Publisher
Springer Singapore
Book
Fluorination

Print ISBN: 978-981-10-3895-2

Electronic ISBN: 978-981-10-3896-9

Copyright Year: 2020

DOI
https://doi.org/10.1007/978-981-10-3896-9_59

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