2007 | OriginalPaper | Chapter
Biclusters Evaluation Based on Shifting and Scaling Patterns
Authors : Juan A. Nepomuceno, Alicia Troncoso Lora, Jesús S. Aguilar–Ruiz, Jorge García–Gutiérrez
Published in: Intelligent Data Engineering and Automated Learning - IDEAL 2007
Publisher: Springer Berlin Heidelberg
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Microarray techniques have motivated the develop of different methods to extract useful information from a biological point of view. Biclustering algorithms obtain a set of genes with the same behaviour over a group of experimental conditions from gene expression data. In order to evaluate the quality of a bicluster, it is useful to identify specific tendencies represented by patterns on data. These patterns describe the behaviour of a bicluster obtained previously by an adequate biclustering technique from gene expression data. In this paper a new measure for evaluating biclusters is proposed. This measure captures a special kind of patterns with scaling trends which represents quality patterns. They are not contemplated with the previous evaluating measure accepted in the literature. This work is a first step to investigate methods that search biclusters based on the concept of shift and scale invariance. Experimental results based on the yeast cell cycle and the human B-cell lymphoma datasets are reported. Finally, the performance of the proposed technique is compared with an optimization method based on the Nelder-Mead Simplex search algorithm.