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2022 | OriginalPaper | Chapter

Biomechanical Aspects of in Vitro Fertilization

Authors : Liliya Batyuk, Anatoly Khalin, Natalia Kizilova

Published in: Biomechanics in Medicine, Sport and Biology

Publisher: Springer International Publishing

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Abstract

During the last decades, in vitro fertilization (IVF) became one of the most demanded reproductive technologies used for infertility treatment. Despite the significant efforts, the percentage of successful procedures remains moderate (<50%). It is shown, the percentage of successful IVF could be increased by a patient-specific embryo transfer based on the preliminary biomechanical and CFD analyses. A detailed review on different aspects of the IVF procedure is given. CFD simulations on the embryo transfer with tubular fluid and air bubble through a thin rigid tube (catheter) have been carried out. The following parameters were found to be the most influencing on the embryo transfer to the fundus: (i) the injection time IT, (ii) the distance of the catheter tip to fundus; (iii) the injected volume during the first stage; (iv) duration of the second stage; (v) the withdrawal speed at which the catheter is removed at the last stage; (vi) the volume replacement during catheter withdrawal. The IT, catheter load speed and cumulative shear stress over the particle during the IT were found the main prognostic factors of the IVF success.

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Literature
1.
2.
Krupinski P., Chickarmane, V., Peterson, C.: Simulating the mammalian blastocyst - molecular and mechanical interactions pattern the embryo. Comput. Biol. 7(5), e1001128 (2011)
3.
Yanez, L.Z., Camarillo, D.B.: Microfluidic analysis of oocyte and embryo biomechanical properties to improve outcomes in assisted reproductive technologies. Mol. Hum. Reprod. 23(4), 235–247 (2017)CrossRef
4.
Huang, S., Ingber, D.E.: The structural and mechanical complexity of cell-growth control. Nat. Cell Biol. 1, E131–E138 (1999)CrossRef
5.
Chicurel, M.E., Chen, C.S., Ingber, D.E.: Cellular control lies in the balance of forces. Curr. Opin. Cell Biol. 10, 232–239 (1998)CrossRef
6.
Janmey, P.A.: The cytoskeleton and cell signaling: component localization and mechanical coupling. Physiol. Rev. 78, 763–781 (1998)CrossRef
7.
Wang, J.H.-C., Thampatty, B.P.: An introductory review of cell mechanobiology. Biomech. Model Mechanobiol. 5, 1–16 (2006)CrossRef
8.
Huang, A.H., Farrell, M.J., Kim, M., Mauck, R.L.: Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogels. Eur. Cells Mater. 19, 72–85 (2010)
9.
Engler, A.J., Sen, S., Sweeney, H.L., Discher, D.E.: Matrix elasticity directs stem cell lineage specification. Cell 126, 677–689 (2006)CrossRef
10.
Suresh, S., et al.: Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. Acta Biomater. 1, 15–30 (2005)CrossRef
11.
Xu, W., et al.: Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells. PLoS ONE 7, e46609 (2012)
12.
13.
Batyuk, L., Kizilova, N.: Dielectric properties of red blood cells for cancer diagnostics and treatment. AS Cancer Biol. 2(10), 55–60 (2018)
14.
Foo, J.Y., Lim, C.S.: Biofluid mechanics of the human reproductive process: modelling of the complex interaction and pathway to the oocytes. Zygote 16, 343–354 (2008)CrossRef
15.
Muglia, U., Motta, P.M.: A new morpho-functional classification of the Fallopian tube based on its three-dimensional myoarchitecture. Histol. Histopathol. 16, 227–237 (2001)
16.
Kim, M.S., Bae, C.Y., Wee, G., Han, Y.M., Park, J.K.: A microfluidic in vitro cultivation system for mechanical stimulation of bovine embryos. Electrophoresis 30, 3276–3282 (2009)CrossRef
17.
Beebe, D., Wheeler, M., Zeringue, H., Walters, E., Raty, S.: Microfluidic technology for assisted reproduction. Theriogenology 57, 125–135 (2002)CrossRef
18.
Swain, J.E., Smith, G.D.: Advances in embryo culture platforms: novel approaches to improve preimplantation embryo development through modifications of the microenvironment. Hum. Reprod. Update. 17, 541–557 (2011)CrossRef
19.
Wheeler, M.B., Walters, E.M., Beebe, D.J.: Toward culture of single gametes: the development of microfluidic platforms for assisted reproduction. Theriogenology 68, S178–S189 (2007)CrossRef
20.
Krisher, R.L., Wheeler, M.B.: Towards the use of microfluidics for individual embryo culture. Reprod. Fertil. Dev. 22, 32 (2010)
21.
Lai, D., Smith, G.D., Takayama, S.: Lab-on-a-chip biophotonics: its application to assisted reproductive technologies. J. Biophotonics. 5, 650–660 (2012)CrossRef
22.
Hwang, H., Lu, H.: Microfluidic tools for developmental studies of small model organisms-nematodes, fruit flies, and zebrafish. Biotechnol. J. 8, 192–205 (2013)CrossRef
23.
Khalilian, M., Navidbakhsh, M., Valojerdi, M.R., Chizari, M., Yazdi, P.E.: Estimating Young’s modulus of zona pellucida by micropipette aspiration in combination with theoretical models of ovum. J. R. Soc. Interface 7, 687–694 (2010)
24.
Dean, J.: Biology of mammalian fertilization: the role of the zona pellucida. J. Clin. Invest. 89, 1055–1059 (1992)CrossRef
25.
Green, D.P.L.: Three-dimensional structure of the zona pellucida. Rev. Reprod. 2, 147–156 (1997)CrossRef
26.
Liu, X., Fernandes, R., Jurisicova, A., Casper, R.F., Sun, Y.: In situ mechanical characterization of mouse oocytes using a cell holding device. Lab. Chip. 10, 2154–2161 (2010)CrossRef
27.
Murayama, Y., et al.: Omata Mouse zona pellucida dynamically changes its elasticity during oocyte maturation, fertilization and early embryo development. Human Cell 19, 119–125 (2006)
28.
Murayama, Y., et al.: Elasticity measurement of zona Pellucida using a micro tactile sensor to evaluate embryo quality. J. Mamm. Ova. Res. 25, 8–16 (2008)
29.
Khalilian, M., Navidbakhsh, M., Valojerdi, M.R., Chizari, M., Yazdi, P.E.: Alteration in the mechanical properties of human ovum zona pellucida following fertilization: experimental and analytical studies. Exp. Mech. 51, 175–182 (2011)CrossRef
30.
Liu, X., Shi, J., Zong, Z., Wan, K.-T., Sun, Y.: Elastic and viscoelastic characterization of mouse oocytes using micropipette indentation. Ann. Biomed. Eng. 40(10), 2122–2130 (2012)CrossRef
31.
Moeendarbary, E., Valon, L., Fritzsche, M., et al.: The cytoplasm of living cells behaves as a poroelastic material. Nature 12(3), 253–261 (2013)
32.
Liu, X., Kim, K., Zhang, Y., Sun, Y.: NanoNewton force sensing and control in microrobotic cell manipulation. Int. J. Robot. Res. 28, 1065–1076 (2009)
33.
Yanez, L.Z., Han, J., Behr, B.B., Pera, R.A.R., Camarillo, D.B.: Human oocyte developmental potential is predicted by mechanical properties within hours after fertilization. Nature Commun. 7, 10809 (2016)
34.
35.
Osada, H., Tsunoda, I., Matsuura, M., Satoh, K., Kanayama, K., Nakayama, Y.: Investigation of ovum transport in the oviduct: the dynamics of oviductal fluids in domestic rabbits. J. Int. Med. Res. 27, 176–180 (1999)CrossRef
36.
Anand, S., Guha, S.K.: Mechanics of transport of the ovum in the oviduct. Med. Biol. Eng. Comput. 16, 256–261 (1998)CrossRef
37.
Paltieli, Y., Weichselbaum, A., Hoffman, N., et al.: Laser scattering instrument for real time in-vivo measurement of ciliary activity in human fallopian tubes. Hum. Reprod. 10, 1638–1641 (1995)CrossRef
38.
Misra, J.C.: Biomathematics: Modelling and Simulation. World Scientific (2006)
39.
Leng, Z., Moore, D.E., Mueller, B.A., Critchlow, C.W., Patton, D.L., et al.: Characterization of ciliary activity in distal Fallopian tube biopsies of women with obstructive tubal infertility. Hum. Reprod. 11, 3121–3127 (1998)CrossRef
40.
Montenegro-Johnson, Th.D., Smith, A.A., Smith, D.J., Loghin, D., Blake, J.R.: Modelling the fluid mechanics of cilia and flagella in reproduction and development. Eur. Phys. J. E 35, 111 (2012)
41.
Isachenko, V.: In-vitro culture of human embryos with mechanical micro-vibration increases implantation rates. Reprod. BioMed. Online 22, 536–544 (2011)
42.
Ezzati, M., Djahanbakhch, O., Arian, S., Carr, B.R.: Tubal transport of gametes and embryos: a review of physiology and pathophysiology. J. Assist. Reprod. Genet. 31, 1337–1347 (2014)
43.
Eytan, O., Elad, D.: Analysis of intra-uterine fluid motion induced by uterine contractions. Bull. Math. Biol. 61(2), 221–238 (1999)MATHCrossRef
44.
Li, M.J., Brasseur, J.G.: Nonsteady peristaltic transport in finite-length tubes. J. Fluid Mech. 248, 129–151 (1993)MATHCrossRef
45.
Mernone, A.V., Mazumdar, J.N., Lucas, S.K.: A mathematical study of peristaltic transport of a Casson fluid. Math. Comp. Model. 35, 895–912 (2002)MathSciNetMATHCrossRef
46.
Eytan, O., Jaffa, A.L., Elad, D.: Peristaltic flow in a tapered channel: application to embryo transport within the uterine cavity. Med. Eng. Phys. 23, 473–482 (2001)CrossRef
47.
Blake, J.R., Vann, P.G., Winet, H.: A model of ovum transport. J. Theor. Biol. 102, 145–166 (1983)CrossRef
48.
Verdugo, P., Lee, W., Halbert, S., Blandau, R., Tam, P.: A stochastic model for oviductal egg transport. Biophys. J. 29, 257–270 (1980)CrossRef
49.
Aranda, V., Cortez, R., Fauci, L.: Stokesian peristaltic pumping in a three-dimensional tube with a phase-shifted asymmetry. Phys. Fluids. 23, 081901–081910 (2011)MATHCrossRef
50.
Aranda, V., Cortez, R., Fauci, L.: A model of Stokesian peristalsis and vesicle transport in a three-dimensional closed cavity. J. Biomech. 48, 1631–1638 (2015)CrossRef
51.
Levi Setti, P,.E., Albani, E., Cavagna, M., Bulletti, C., Colombo, G.V., Negri, L.: The impact of embryo transfer on implantation - a review. Placenta 24(Suppl.B), S20–26 (2003)
52.
Sadeghi, M.R.: The 40th anniversary of IVF: has art’s success reached its peak? J. Reprod. Infertil. 19(2), 67–68 (2018)
53.
Lauko, I.G., Rinaudo, P., Dashev S.: A computational parameter study of embryo transfer. Ann. Biomed. Eng. 35(4), 659–671 (2007)
54.
van Weering, H.G., Schats, R., McDonnell, J., Vink, J.M., Vermeiden, J.P., Hompes, P.G.: The impact of the embryo transfer catheter on the pregnancy rate in IVF. Hum. Reprod. 17, 666–670 (2002)CrossRef
55.
Eytan, O., Zaretsky, U., Jaffa, A.J., Elad, D.: In vitro simulations of embryo transfer in a laboratory model of the uterus. J. Biomech. 40, 1073–1080 (2007)CrossRef
56.
Lambers, M.J., Dogan, E., Kostelijk, H., Lens, J.W., Schats, R., Hompes, P.G.: Ultrasonographicguided embryo transfer does not enhance pregnancy rates compared with embryo transfer based on previous uterine length measurement. Fertil. Steril. 86, 867–872 (2006)CrossRef
57.
Mansour, R.T., Aboulghar, M.A.: Optimizing the embryo transfer technique. Hum. Reprod. 17, 1149–1153 (2002)CrossRef
58.
Frankfurter, D., Trimarchi, J.B., Silva, C.P., Keefe, D.L.: Middle to lower uterine segment embryo transfer improves implantation and pregnancy rates compared with fundal embryo transfer. Fertil. Steril. 81, 1273–1277 (2004)CrossRef
59.
Tiras, B., Polat, M., Korucuoglu, U., Zeyneloglu, H.B., Yarali, H.: Impact of embryo replacement depth on in vitro fertilization and embryo transfer outcomes. Fertil. Steril. 94, 1341–1345 (2010)CrossRef
60.
Rovei, V., et al.: IVF outcome is optimized when embryos are replaced between 5 and 15 mm from the fundal endometrial surface: a prospectivf Yanez e analysis on 1184 IVF cycles. Reprod. Biol. Endocrinol. 11, 114 (2013)CrossRef
61.
Cenksoy, P.O., Fıcıcıoglu, C., Yesiladali, M., Akcin, O.A., Kaspar, C.: The importance of the length of uterine cavity, the position of the tip of the inner catheter and the distance between the fundal endometrial surface and the air bubbles as determinants of the pregnancy rate in IVF cycles. Eur. J. Obstet. Gynecol. Reprod. Biol. 172, 46–50 (2014)CrossRef
62.
Caanen, M.R., et al.: Hompes embryo transfer with controlled injection speed to increase pregnancy rates: a randomized controlled trial. Gynecol. Obstet. Invest. 81, 394–404 (2016)
63.
Groeneveld, E., et al.: Standardization of catheter load speed during embryo transfer: comparison of manual and pump-regulated embryo transfer. Reprod. Biomed. Online 24(2), 163–169 (2012)CrossRef
64.
Schoolcraft, W.B.: Importance of embryo transfer technique in maximizing assisted reproductive outcomes. Fertil. Steril. 105(4), 855–860 (2016)CrossRef
65.
Bilalis, D., et al.: Use of different loading techniques for embryo transfer increasing the risk of ectopic pregnancy. Hum. Reprod. (Abstract Book, P-479) 17, 162 (2002)
66.
Yaniv, S., Elad, D., Jaffa, A.J., Eytan, O.: Biofluid aspects of embryo transfer. Ann. Biomed. Eng. 31, 1255–1262 (2003)CrossRef
67.
Feng, J.Q.: A long gas bubble moving in a tube with flowing liquid. Int. J. Multiph. Flow 35, 738–746 (2009)CrossRef
68.
Leverett, L.B., et al.: Red blood cell damage by shear stress. Biophys. J. 12(3), 257–273 (1972)CrossRef
69.
Parfitt, H.S., Davies, S.V., Tighe, P., Ewings, P.: Red cell damage after pumping by two infusion control devices (Arcomed VP 7000 and IVAC 572). Transfus. Med. 17(4), 290–295 (2007)CrossRef
70.
71.
Goubergrits, L., Affeld, K.: Numerical estimation of blood damage in artificial organs. Artif. Organs 28(5), 499–507 (2004)CrossRef
72.
Yeleswarapu, K.K., et al.: A mathematical model for shear-induced hemolysis. Artif. Organs 19(7), 576–582 (1995)CrossRef
73.
Xie, Y., Wang, F., Zhong, W., et al.: Shear stress induces preimplantation embryo death that is delayed by the zona pellucida and associated with stress-activated protein kinase mediated apoptosis. Biol. Reprod. 75, 45–55 (2006)CrossRef
74.
75.
Elad, D., Jaffa, A.J., Grisaru, D.: Biomechanics of early life in the female reproductive tract. Physiology 35, 134–143 (2020)CrossRef
76.
Xi, Q., Yang, Q., Wang, M., et al.: Individualized embryo selection strategy developed by stacking machine learning model for better in vitro fertilization outcomes: an application study. Reprod. Biol. Endocrinol. 19(1), 53 (2021)CrossRef
Metadata
Title
Biomechanical Aspects of in Vitro Fertilization
Authors
Liliya Batyuk
Anatoly Khalin
Natalia Kizilova
Copyright Year
2022
Book
Biomechanics in Medicine, Sport and Biology

Print ISBN: 978-3-030-86296-1

Electronic ISBN: 978-3-030-86297-8

Copyright Year: 2022

DOI
https://doi.org/10.1007/978-3-030-86297-8_1