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2015 | OriginalPaper | Chapter

Cell-Free Layer Measurements in a Network with Bifurcating Microchannels Using a Global Approach

Authors : David Bento, Diana Pinho, Ana I. Pereira, Rui Lima

Published in: Operational Research

Publisher: Springer International Publishing

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Abstract

One of the most interesting hemodynamic phenomenon observed in microchannels is the existence of a marginal cell-free layer (CFL) at regions adjacent to the wall. This is a well known phenomenon that occurs in simple glass capillaries and in vivo microvessels, but has never been investigated in detail in biomedical microdevices containing complex geometries. In the present chapter, in vitro blood flowing through bifurcating microchannels was studied, with the aim of characterizing the cell-free layer (CFL). For that three different videos with different hematocrit and flow rates were considered. All images were obtained by means of a high-speed video microscopy system and then processed in MatLab using the Image Processing toolbox. The numerical data was obtained automatically and analyzed by optimization techniques using the genetic algorithm approach. The results suggest that the CFL were formed in a similar way at the upper and lower regions in all bifurcations.

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Metadata
Title
Cell-Free Layer Measurements in a Network with Bifurcating Microchannels Using a Global Approach
Authors
David Bento
Diana Pinho
Ana I. Pereira
Rui Lima
Copyright Year
2015
Book
Operational Research

Print ISBN: 978-3-319-20327-0

Electronic ISBN: 978-3-319-20328-7

Copyright Year: 2015

DOI
https://doi.org/10.1007/978-3-319-20328-7_4

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