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Published in:
2015 | OriginalPaper | Chapter
Comparative Study on Human A-Glucosidase
Authors : Q. Ong, L. Le
Published in: 5th International Conference on Biomedical Engineering in Vietnam
Publisher: Springer International Publishing
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α
-glucosidase is an enzyme in human encoded by GAA gene [1]. Normally, this enzyme is essential for the degradation of glycogen to glucose in lysosomes. However, with patients of diabetes mellitus type 2,
α
-glucosidase causes the unwanted elevation of blood glucose level. Therefore,
α
-glucosidase is now the target of anti-diabetic drugs. In this study, structure of human
α
-glucosidase was investigated using the approaches of bioinformatics tools. The results from phylogenetic tree also suggest the Mus musculus for animal testing. Finally, some approved
α
-glucosidase inhibitor drugs from Drugbank database are tested for binding affinity energy and pharmacophore features.