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Published in:
2016 | OriginalPaper | Chapter
Comparison of Flow Cytometry and Image-Based Screening for Cell Cycle Analysis
Authors : Damian J. Matuszewski, Ida-Maria Sintorn, Jordi Carreras Puigvert, Carolina Wählby
Published in: Image Analysis and Recognition
Publisher: Springer International Publishing
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Abstract
Quantitative cell state measurements can provide a wealth of information about mechanism of action of chemical compounds and gene functionality. Here we present a comparison of cell cycle disruption measurements from commonly used flow cytometry (generating one-dimensional signal data) and bioimaging (producing two-dimensional image data). Our results show high correlation between the two approaches indicating that image-based screening can be used as an alternative to flow cytometry. Furthermore, we discuss the benefits of image informatics over conventional single-signal flow cytometry.