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05-05-2022 | Original Article

Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys

Authors: Nicolas Fuentes, Alexis Garcia, Ramón Guevara, Roberto Orofino, Diego M. Mateos

Published in: Neuroinformatics | Issue 4/2022

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Abstract

The use of anaesthesia is a fundamental tool in the investigation of consciousness. Anesthesia procedures allow to investigate different states of consciousness from sedation to deep anesthesia within controlled scenarios. In this study we use information quantifiers to measure the complexity of electrocorticogram recordings in monkeys. We apply these metrics to compare different stages of general anesthesia for evaluating consciousness in several anesthesia protocols. We find that the complexity of brain activity can be used as a correlate of consciousness. For two of the anaesthetics used, propofol and medetomidine, we find that the anaesthetised state is accompanied by a reduction in the complexity of brain activity. On the other hand we observe that use of ketamine produces an increase in complexity measurements. We relate this observation with increase activity within certain brain regions associated with the ketamine used doses. Our measurements indicate that complexity of brain activity is a good indicator for a general evaluation of different levels of consciousness awareness, both in anesthetized and non anesthetizes states.

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Title: Complexity of Brain Dynamics as a Correlate of Consciousness in Anaesthetized Monkeys
Authors: Nicolas Fuentes
Alexis Garcia
Ramón Guevara
Roberto Orofino
Diego M. Mateos
Publication date: 05-05-2022
Publisher: Springer US
Published in: Neuroinformatics / Issue 4/2022
Print ISSN: 1539-2791
Electronic ISSN: 1559-0089
DOI: https://doi.org/10.1007/s12021-022-09586-3

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