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Immune Response Model Fitting to CD4 T Cell Data in Lymphocytic Choriomeningitis Virus LCMV infection Read chapter Read first chapter

2021 | OriginalPaper | Chapter

Construction of a New Model to Investigate Breast Cancer Data

Authors : Umut Ağyüz, Vilda Purutçuoğlu, Eda Purutçuoğlu, Yüksel Ürün

Published in: Modeling, Dynamics, Optimization and Bioeconomics IV

Publisher: Springer International Publishing

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Abstract

Modelling is a way to describe the elements of the network/system, their states and their interactions with other elements in order to understand the current state of knowledge of a system. Thereby, the mathematical models may predict the experiments which are difficult or impossible to do in the lab and can be used to discover indirect relationships between model’s components. Hereby, the aim of this study is to develop a network structure for the breast cancer from the analyses of different datasets which include the data of the luminal type at the stage 1–3 breast cancer diagnosed in total 377 patients and related to the PI3KCD signalling pathway. Accordingly, in the analyses, the relations of the 65 oncogenes are revealed by a true network in a binary format. Then, we construct the quasi breast cancer networks by using different parametric and non-parametric models, namely, Gaussian graphical model, copula Gaussian graphical model and multivariate adaptive regression splines with/without interaction terms. In the computations, we evaluate the performance of all suggested mathematical models via F-measure and accuracy measure criteria. We consider that the outcomes can be useful for the selection of the best fitted model in the construction of the breast cancer gene-gene interaction networks.

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previous chapter Immune Response Model Fitting to CD4 T Cell Data in Lymphocytic Choriomeningitis Virus LCMV infection
next chapter Optimal Pension Fund Management Under Risk and Uncertainty: The Case Study of Poland
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Metadata
Title
Construction of a New Model to Investigate Breast Cancer Data
Authors
Umut Ağyüz
Vilda Purutçuoğlu
Eda Purutçuoğlu
Yüksel Ürün
Copyright Year
2021
Book
Modeling, Dynamics, Optimization and Bioeconomics IV

Print ISBN: 978-3-030-78162-0

Electronic ISBN: 978-3-030-78163-7

Copyright Year: 2021

DOI
https://doi.org/10.1007/978-3-030-78163-7_2

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