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2013 | OriginalPaper | Chapter

Design of Pathway-Level Bioprocess Monitoring and Control Strategies Supported by Metabolic Networks

Authors : Inês A. Isidro, Ana R. Ferreira, João J. Clemente, António E. Cunha, João M. L. Dias, Rui Oliveira

Published in: Measurement, Monitoring, Modelling and Control of Bioprocesses

Publisher: Springer Berlin Heidelberg

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Abstract

In this chapter we explore the basic tools for the design of bioprocess monitoring, optimization, and control algorithms that incorporate a priori knowledge of metabolic networks. The main advantage is that this ultimately enables the targeting of intracellular control variables such as metabolic reactions or metabolic pathways directly linked with productivity and product quality. We analyze in particular design methods that target elementary modes of metabolic networks. The topics covered include the analysis of the structure of metabolic networks, computation and reduction of elementary modes, measurement methods for the envirome, envirome-guided metabolic reconstruction, and macroscopic dynamic modeling and control. These topics are illustrated with applications to a cultivation process of a recombinant Pichia pastoris X33 strain expressing a single-chain antibody fragment (scFv).

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Metadata
Title
Design of Pathway-Level Bioprocess Monitoring and Control Strategies Supported by Metabolic Networks
Authors
Inês A. Isidro
Ana R. Ferreira
João J. Clemente
António E. Cunha
João M. L. Dias
Rui Oliveira
Copyright Year
2013
Publisher
Springer Berlin Heidelberg
Book
Measurement, Monitoring, Modelling and Control of Bioprocesses

Print ISBN: 978-3-642-36837-0

Electronic ISBN: 978-3-642-36838-7

Copyright Year: 2013

DOI
https://doi.org/10.1007/10_2012_168

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