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Published in:
2008 | OriginalPaper | Chapter
Deterministic Compartmental Models: Extensions of Basic Models
Author : P. van den Driessche
Published in: Mathematical Epidemiology
Publisher: Springer Berlin Heidelberg
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The basic compartmental models for disease transmission are extended to include three separate biological features. The first such feature is vertical transmission of disease, for which two ordinary differential equation models (SIR and SEIR) are formulated and analyzed. In particular, vertical transmission is shown to increase the basic reproduction number. Immigration of infective individuals is considered as a second feature, and the resulting model has a unique endemic equilibrium (with no disease-free state). An illustration is provided that includes screening and isolating infectives to reduce the spread of disease. A constant period of temporary immunity is introduced in an SIRS model as the third feature. This results in an integrodifferential equation for the fraction of infectives. Analysis shows that, for some parameter values, Hopf bifurcation can give rise to periodic solutions.