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Published in:
On Applying Optimal Design of Experiments when Functional Observations Occur Read chapter Read first chapter

2016 | OriginalPaper | Chapter

Efficient Circular Cross-over Designs for Models with Interaction

Author : Pierre Druilhet

Published in: mODa 11 - Advances in Model-Oriented Design and Analysis

Publisher: Springer International Publishing

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Abstract

Cross-over designs are widely used in many areas such as clinical trials or agricultural field experiments. In addition to the effect of the treatment applied to a given period, a residual effect of the previous treatment is often observed. In that case, the effect observed depends on both treatments. When the aim of the experiment is to select a single treatment, it is natural to consider the effect of a treatment preceded by itself, also called the total effect. We consider universally optimal or efficient circular cross-over designs for total effects under a model with interaction between treatment and carry-over effects. The optimal designs are obtained from the theory of approximate designs developed by Kushner (Ann Stat 25:2328–2344, 1997).

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previous chapter PKL-Optimality Criterion in Copula Models for Efficacy-Toxicity Response
next chapter Survival Models with Censoring Driven by Random Enrollment
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Metadata
Title
Efficient Circular Cross-over Designs for Models with Interaction
Author
Pierre Druilhet
Copyright Year
2016
Book
mODa 11 - Advances in Model-Oriented Design and Analysis

Print ISBN: 978-3-319-31264-4

Electronic ISBN: 978-3-319-31266-8

Copyright Year: 2016

DOI
https://doi.org/10.1007/978-3-319-31266-8_11

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