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2020 | OriginalPaper | Chapter

Empirical Modeling of Photopolymerization for Oxygen-Mediated Anti-cancer

Authors : Kuo-Ti Chen, Jui-Teng Lin, Hsia-Wei Liu

Published in: Future Trends in Biomedical and Health Informatics and Cybersecurity in Medical Devices

Publisher: Springer International Publishing

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Abstract

The dynamic roles of photosensitizer (PS) concentration and light intensity were measured and analyzed. The efficacy of photodynamic therapy (PDT) and cell viability (CV) are measured (in vitro) and analyzed by analytic and numerical modeling. For a fixed PS concentration, CV is a nonlinear deceasing function of light intensity and exposure time; for a fixed light intensity, higher PS concentration achieves higher efficacy or smaller CV (at steady-state), in consistent to our analytic formulas. Finally, anti-cancer efficacy may be enhanced by the resupply of PS and/or external oxygen.

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Metadata
Title
Empirical Modeling of Photopolymerization for Oxygen-Mediated Anti-cancer
Authors
Kuo-Ti Chen
Jui-Teng Lin
Hsia-Wei Liu
Copyright Year
2020
Book
Future Trends in Biomedical and Health Informatics and Cybersecurity in Medical Devices

Print ISBN: 978-3-030-30635-9

Electronic ISBN: 978-3-030-30636-6

Copyright Year: 2020

DOI
https://doi.org/10.1007/978-3-030-30636-6_37