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Chiral Derivatizing Agents, Macrocycles, Metal Complexes, and Liquid Crystals for Enantiomer Differentiation in NMR Spectroscopy Read chapter Read first chapter

2013 | OriginalPaper | Chapter

Enantiopure Supramolecular Cages: Synthesis and Chiral Recognition Properties

Authors : Thierry Brotin, Laure Guy, Alexandre Martinez, Jean-Pierre Dutasta

Published in: Differentiation of Enantiomers II

Publisher: Springer International Publishing

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Abstract

Enantiopure compounds are ubiquitous in the chemical sciences and present a particular interest in the field of molecular recognition and host-guest systems. Indeed, chiral molecular receptors are at the basis of numerous biological recognition processes and have important implications in biochemistry or pharmacology. Chemists have been investigating this field for several decades, which has led to the development of the synthesis of chiral hosts, their enantiomeric differentiation, and the studies of their recognition properties towards important and bio-relevant chiral guest substrates. The design of molecular cages is a rather difficult task that is even more demanding when enantiopure molecules are required. In this review we chose to present the main families of synthetic organic supramolecular cages that have been developed, whose structures contain stereogenic centers or present an inherent chirality, giving rise to chiral supramolecular cages. Particular attention is given to obtaining enantiopure compounds. Their recognition properties are also underlined. A last important aspect of the review is to present how chiroptical spectroscopies can be used to characterize the recognition phenomena displayed by supramolecular cages.

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previous chapter Chiral Sensor Devices for Differentiation of Enantiomers
next chapter Interconversion of Stereochemically Labile Enantiomers (Enantiomerization)
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Metadata
Title
Enantiopure Supramolecular Cages: Synthesis and Chiral Recognition Properties
Authors
Thierry Brotin
Laure Guy
Alexandre Martinez
Jean-Pierre Dutasta
Copyright Year
2013
Book
Differentiation of Enantiomers II

Print ISBN: 978-3-319-03715-8

Electronic ISBN: 978-3-319-03716-5

Copyright Year: 2013

DOI
https://doi.org/10.1007/128_2013_487

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