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2020 | OriginalPaper | Chapter

Enhancing Breast Cancer Classification via Information and Multi-model Integration

Authors : J. C. Morales, Francisco Carrillo-Perez, Daniel Castillo-Secilla, Ignacio Rojas, Luis Javier Herrera

Published in: Bioinformatics and Biomedical Engineering

Publisher: Springer International Publishing

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Abstract

The integration of different sources of information for proper classification is of utter importance, specially in the biomedical field. Many different sources of information can be collected from a patient and they all may contribute to an accurate diagnosis. For example in cancer disease these can include gene expression (RNA-Seq) or Tissue Slide Imaging, however, their integration in order to correctly train a classification model is not straightforward. Making use of Whole-Slide-Images, this work presents a novel information integration model when different sources of data from a patient are available, named as Multi-source integration model (MSIM). Using two different Convolutional Neural Networks architectures and a Feed Forward Neural Network, the potential of a multi-model integration process which combines the information of different sources is introduced and its results are presented for Breast Cancer classification.

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Literature
1.
go back to reference Siegel, R.L., Miller, K.D., Jemal, A.: Cancer statistics. CA: A Cancer J. Clin. 69(1), 7–34 (2019) Siegel, R.L., Miller, K.D., Jemal, A.: Cancer statistics. CA: A Cancer J. Clin. 69(1), 7–34 (2019)
4.
go back to reference Castillo, D., et al.: Leukemia multiclass assessment and classification from microarray and RNA-seq technologies integration at gene expression level. PloS One 14(2), 1–25 (2019) CrossRef Castillo, D., et al.: Leukemia multiclass assessment and classification from microarray and RNA-seq technologies integration at gene expression level. PloS One 14(2), 1–25 (2019) CrossRef
5.
go back to reference Öztürk, Ş., Akdemir, B.: HIC-net: a deep convolutional neural network model for classification of histopathological breast images. Comput. Electr. Eng. 76, 299–310 (2019)CrossRef Öztürk, Ş., Akdemir, B.: HIC-net: a deep convolutional neural network model for classification of histopathological breast images. Comput. Electr. Eng. 76, 299–310 (2019)CrossRef
6.
go back to reference Gálvez, J.M., et al.: Towards improving skin cancer diagnosis by integrating microarray and RNA-seq datasets. IEEE J. Biomed. Health Inf. (2019) Gálvez, J.M., et al.: Towards improving skin cancer diagnosis by integrating microarray and RNA-seq datasets. IEEE J. Biomed. Health Inf. (2019)
7.
go back to reference Qaiser, T., Tsang, Y.W., Taniyama, D., Sakamoto, N., Nakane, K., Epstein, D., Rajpoot, N.: Fast and accurate tumor segmentation of histology images using persistent homology and deep convolutional features. Med. Image Anal. 55, 1–14 (2019)PubMedCrossRef Qaiser, T., Tsang, Y.W., Taniyama, D., Sakamoto, N., Nakane, K., Epstein, D., Rajpoot, N.: Fast and accurate tumor segmentation of histology images using persistent homology and deep convolutional features. Med. Image Anal. 55, 1–14 (2019)PubMedCrossRef
8.
go back to reference Gecer, B., Aksoy, S., Mercan, E., Shapiro, L.G., Weaver, D.L., Elmore, J.G.: Detection and classification of cancer in whole slide breast histopathology images using deep convolutional networks. Pattern Recogn. 84, 345–356 (2018)CrossRef Gecer, B., Aksoy, S., Mercan, E., Shapiro, L.G., Weaver, D.L., Elmore, J.G.: Detection and classification of cancer in whole slide breast histopathology images using deep convolutional networks. Pattern Recogn. 84, 345–356 (2018)CrossRef
9.
go back to reference Benhammou, Y., Achchab, B., Herrera, F., Tabik, S.: BreakHis based breast cancer automatic diagnosis using deep learning: taxonomy, survey and insights. Neurocomputing 375, 9–24 (2020)CrossRef Benhammou, Y., Achchab, B., Herrera, F., Tabik, S.: BreakHis based breast cancer automatic diagnosis using deep learning: taxonomy, survey and insights. Neurocomputing 375, 9–24 (2020)CrossRef
10.
go back to reference Simonyan, K., Zisserman, A.: Two-stream convolutional networks for action recognition in videos. In: Advances in Neural Information Processing Systems, pp. 568–576 (2014) Simonyan, K., Zisserman, A.: Two-stream convolutional networks for action recognition in videos. In: Advances in Neural Information Processing Systems, pp. 568–576 (2014)
11.
go back to reference Carreira, J., Zisserman, A.: Quo Vadis, action recognition? A new model and the kinetics dataset. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 6299–6308 (2017) Carreira, J., Zisserman, A.: Quo Vadis, action recognition? A new model and the kinetics dataset. In Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 6299–6308 (2017)
12.
13.
go back to reference Grossman, R.L., Heath, A.P., Ferretti, V., Varmus, H.E., Lowy, D.R., Kibbe, W.A., Staudt, L.M.: Toward a shared vision for cancer genomic data. N. Engl. J. Med. 375(12), 1109–1112 (2016)PubMedPubMedCentralCrossRef Grossman, R.L., Heath, A.P., Ferretti, V., Varmus, H.E., Lowy, D.R., Kibbe, W.A., Staudt, L.M.: Toward a shared vision for cancer genomic data. N. Engl. J. Med. 375(12), 1109–1112 (2016)PubMedPubMedCentralCrossRef
15.
go back to reference Otsu, N.: A threshold selection method from gray-level histograms. IEEE Trans. Syst. Man Cybern. 9(1), 62–66 (1979)CrossRef Otsu, N.: A threshold selection method from gray-level histograms. IEEE Trans. Syst. Man Cybern. 9(1), 62–66 (1979)CrossRef
16.
go back to reference He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016) He, K., Zhang, X., Ren, S., Sun, J.: Deep residual learning for image recognition. In: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, pp. 770–778 (2016)
17.
go back to reference Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition (2014). arXiv preprint arXiv:1409.1556 Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition (2014). arXiv preprint arXiv:​1409.​1556
18.
go back to reference Glorot, X., Bengio, Y.: Understanding the difficulty of training deep feedforward neural networks. In Proceedings of the Thirteenth International Conference on Artificial Intelligence and Statistics, pp. 249–256, March 2010 Glorot, X., Bengio, Y.: Understanding the difficulty of training deep feedforward neural networks. In Proceedings of the Thirteenth International Conference on Artificial Intelligence and Statistics, pp. 249–256, March 2010
20.
go back to reference Paszke, A., et al.: PyTorch: an imperative style, high-performance deep learning library. In: Advances in Neural Information Processing Systems, pp. 8024–8035 (2019) Paszke, A., et al.: PyTorch: an imperative style, high-performance deep learning library. In: Advances in Neural Information Processing Systems, pp. 8024–8035 (2019)
21.
go back to reference Oliphant, T.E.: A Guide to NumPy, vol. 1. Trelgol Publishing, USA (2006) Oliphant, T.E.: A Guide to NumPy, vol. 1. Trelgol Publishing, USA (2006)
22.
go back to reference Bradski, G., Kaehler, A.: Learning OpenCV: Computer Vision with the OpenCV Library. O’Reilly Media Inc., Newton (2008) Bradski, G., Kaehler, A.: Learning OpenCV: Computer Vision with the OpenCV Library. O’Reilly Media Inc., Newton (2008)
23.
go back to reference Pedregosa, F., et al.: Scikit-learn: machine learning in python. J. Mach. Learn. Res. 12, 2825–2830 (2011) Pedregosa, F., et al.: Scikit-learn: machine learning in python. J. Mach. Learn. Res. 12, 2825–2830 (2011)
Metadata
Title
Enhancing Breast Cancer Classification via Information and Multi-model Integration
Authors
J. C. Morales
Francisco Carrillo-Perez
Daniel Castillo-Secilla
Ignacio Rojas
Luis Javier Herrera
Copyright Year
2020
DOI
https://doi.org/10.1007/978-3-030-45385-5_67

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