Skip to main content
Top

2014 | OriginalPaper | Chapter

Ensemble Glucose Prediction in Insulin-Dependent Diabetes

Authors : Fredrik Ståhl, Rolf Johansson, Eric Renard

Published in: Data-driven Modeling for Diabetes

Publisher: Springer Berlin Heidelberg

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Real-time prediction of glucose in type 1 Diabetes Mellitus has received a considerable amount of scientific and commercial interest over the last decade. Numerous different models have been suggested using both physiological and data-driven approaches. Insulin-dependent diabetic glucose dynamics are known to be subject to time-shifting dynamics. Considering this, as well as the vast number of models developed in the literature, it is unclear if a single model can be determined to be optimal under every possible situation. This raises the question whether it is more useful to use one of the models solely, or if it is possible to gain additional prediction accuracy by combining their outcomes. Here, a novel merging approach—combining elements from both switching and averaging techniques, forming a ‘soft’ switcher in a Bayesian framework—is presented for the glucose prediction application. The method is demonstrated on both simulated and empirical data sets.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literature
2.
go back to reference Ackerman E, Gatewood LC, Rosevear JW, Molnar GD (1965) Model studies of blood- glucose regulation. Bull Math Biophys 27(Special Issue):21–37 Ackerman E, Gatewood LC, Rosevear JW, Molnar GD (1965) Model studies of blood- glucose regulation. Bull Math Biophys 27(Special Issue):21–37
3.
go back to reference Agar B, Eren M, Cinar A (2005) Glucosim: educational software for virtual experiments with patients with type 1 diabetes. In: Proceedings of 2005 annual international conference of the IEEE engineering in medicine and biology (EMBC2005), pp 845–848 Agar B, Eren M, Cinar A (2005) Glucosim: educational software for virtual experiments with patients with type 1 diabetes. In: Proceedings of 2005 annual international conference of the IEEE engineering in medicine and biology (EMBC2005), pp 845–848
4.
go back to reference Alessandri A, Baglietto M, Battistelli G (2005) Receding-horizon estimation for switching discrete-time linear systems. IEEE Trans Autom Control 50(11):1736–1748. doi:10.1109/TAC.2005.858684 Alessandri A, Baglietto M, Battistelli G (2005) Receding-horizon estimation for switching discrete-time linear systems. IEEE Trans Autom Control 50(11):1736–1748. doi:10.​1109/​TAC.​2005.​858684
5.
go back to reference Arenas-Garcia J, Martinez-Ramon M, Navia-Vazquez A, Figueiras-Vidal AR (2006) Plant identification via adaptive combination of transversal filters. Signal Process 86(9):2430–2438. doi:10.1016/j.sigpro.2005.11.008. Special section: Signal processing in UWB communications Arenas-Garcia J, Martinez-Ramon M, Navia-Vazquez A, Figueiras-Vidal AR (2006) Plant identification via adaptive combination of transversal filters. Signal Process 86(9):2430–2438. doi:10.​1016/​j.​sigpro.​2005.​11.​008. Special section: Signal processing in UWB communications
6.
go back to reference Arleth T, Andreasson S, Federici MO, Benedetti MM (2000) A model of the endogenous glucose balance incorporating the characteristics of glucose transporters. Comp Meth Prog Biomed 62:219–234CrossRef Arleth T, Andreasson S, Federici MO, Benedetti MM (2000) A model of the endogenous glucose balance incorporating the characteristics of glucose transporters. Comp Meth Prog Biomed 62:219–234CrossRef
7.
go back to reference Balakrishnan NP, Rangaiah GP, Samavedham L (2011) Review and analysis of blood glucose (BG) models for type 1 diabetic patients. Ind Eng Chem Res 50(21):12041–12066. doi:10.1021/ie2004779 Balakrishnan NP, Rangaiah GP, Samavedham L (2011) Review and analysis of blood glucose (BG) models for type 1 diabetic patients. Ind Eng Chem Res 50(21):12041–12066. doi:10.​1021/​ie2004779
8.
go back to reference Basu R, Di Camillo B, Toffolo G, Basu A, Shah P, Vella A, Rizza R, Cobelli C (2003) Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol 284:E55–E69 Basu R, Di Camillo B, Toffolo G, Basu A, Shah P, Vella A, Rizza R, Cobelli C (2003) Use of a novel triple-tracer approach to assess postprandial glucose metabolism. Am J Physiol 284:E55–E69
9.
go back to reference Berger M, Rodbard D (1989) Computer simulation of plasma insulin and glucose dynamics after subcutaneous insulin injection. Diabetes Care 12(10):725–736CrossRef Berger M, Rodbard D (1989) Computer simulation of plasma insulin and glucose dynamics after subcutaneous insulin injection. Diabetes Care 12(10):725–736CrossRef
10.
go back to reference Bergman RN, Cobelli C (1980) Minimal modeling, partition analysis, and the estimation of insulin sensitivity. Fed Proc 39(1):110–115 Bergman RN, Cobelli C (1980) Minimal modeling, partition analysis, and the estimation of insulin sensitivity. Fed Proc 39(1):110–115
11.
go back to reference Bishop CM (2006) Pattern recognition and machine learning. Springer, Secaucus Bishop CM (2006) Pattern recognition and machine learning. Springer, Secaucus
12.
go back to reference Bolie VW (1961) Coefficients of normal blood glucose regulation. J Appl Phys 16(5):783–788 Bolie VW (1961) Coefficients of normal blood glucose regulation. J Appl Phys 16(5):783–788
14.
go back to reference Bremer T, Gough DA (1999) Is blood glucose predictable from previous values? A solicitation for data. Diabetes 48:445–451CrossRef Bremer T, Gough DA (1999) Is blood glucose predictable from previous values? A solicitation for data. Diabetes 48:445–451CrossRef
15.
go back to reference Breton MD (2008) Physical activity—the major unaccounted impediment to closed loop control. J Diab Sci Technol (Online) 2(1):169–174CrossRef Breton MD (2008) Physical activity—the major unaccounted impediment to closed loop control. J Diab Sci Technol (Online) 2(1):169–174CrossRef
16.
go back to reference Cescon M (2011) Linear modeling and prediction in diabetes physiology. Licentiate Thesis TFRT-3250. Department of Automatic Control, Lund University, Sweden Cescon M (2011) Linear modeling and prediction in diabetes physiology. Licentiate Thesis TFRT-3250. Department of Automatic Control, Lund University, Sweden
17.
go back to reference Chase JG, Shaw G, Le Compte A, Lonergan T, Willacy M, Wong XW, Lin J, Lotz T, Lee D, Hann C (2008) Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change. Crit Care 12(2):R49. doi:10.1186/cc6868 CrossRef Chase JG, Shaw G, Le Compte A, Lonergan T, Willacy M, Wong XW, Lin J, Lotz T, Lee D, Hann C (2008) Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change. Crit Care 12(2):R49. doi:10.​1186/​cc6868 CrossRef
18.
go back to reference Chase JG, Shaw GM, Lotz T, LeCompte A, Wong J, Lin J, Lonergan T, Willacy M, Hann CE (2007) Model-based insulin and nutrition administration for tight glycaemic control in critical care. Curr Drug Deliv 4(4):283–296CrossRef Chase JG, Shaw GM, Lotz T, LeCompte A, Wong J, Lin J, Lonergan T, Willacy M, Hann CE (2007) Model-based insulin and nutrition administration for tight glycaemic control in critical care. Curr Drug Deliv 4(4):283–296CrossRef
19.
go back to reference Clarke WL, Cox D, Gonder-Frederick LA, Carter W, Pohl SL (1987) Evaluating clinical accuracy of systems for self-monitoring of blood glucose. Diabetes Care 10:622–628CrossRef Clarke WL, Cox D, Gonder-Frederick LA, Carter W, Pohl SL (1987) Evaluating clinical accuracy of systems for self-monitoring of blood glucose. Diabetes Care 10:622–628CrossRef
21.
go back to reference Dalla Man C, Camilleri M, Cobelli C (2006) A system model of oral glucose absorption: validation on gold standard data. IEEE Trans Biomed Eng 53(12):2472–2478 Dalla Man C, Camilleri M, Cobelli C (2006) A system model of oral glucose absorption: validation on gold standard data. IEEE Trans Biomed Eng 53(12):2472–2478
22.
go back to reference Dalla Man C, Caumo A, Cobelli C (2002) The oral glucose minimal model: estimation of insulin sensitivity from a meal test. IEEE Trans Biomed Eng 49(5):419–429 Dalla Man C, Caumo A, Cobelli C (2002) The oral glucose minimal model: estimation of insulin sensitivity from a meal test. IEEE Trans Biomed Eng 49(5):419–429
23.
go back to reference Dalla Man C, Raimondo DM, Rizza RA, Cobelli C (2007) GIM, simulation software of meal glucose insulin model. J Diabetes Sci Technol 1(3):1–8 Dalla Man C, Raimondo DM, Rizza RA, Cobelli C (2007) GIM, simulation software of meal glucose insulin model. J Diabetes Sci Technol 1(3):1–8
24.
go back to reference Dalla-Man C, Rizza RA, Cobelli C (2007) Meal simulation model of the glucose-insulin system. IEEE Trans Biomed Eng 54(10):1740–1749CrossRef Dalla-Man C, Rizza RA, Cobelli C (2007) Meal simulation model of the glucose-insulin system. IEEE Trans Biomed Eng 54(10):1740–1749CrossRef
25.
go back to reference Daskalaki E, Norgaard K, Zueger T, Prountzou A, Diem P, Mougiakakou S (2013) An early warning system for hypoglycemic/hyperglycemic events based on fusion of adaptive prediction models. J Diabetes Sci Technol 7(3):689–698CrossRef Daskalaki E, Norgaard K, Zueger T, Prountzou A, Diem P, Mougiakakou S (2013) An early warning system for hypoglycemic/hyperglycemic events based on fusion of adaptive prediction models. J Diabetes Sci Technol 7(3):689–698CrossRef
26.
go back to reference Daskalaki E, Prountzou A, Diem P, Mougiakakou SG (2012) Real-time adaptive models for the personalized prediction of glycemic profile in type 1 diabetes patients. Diabetes Technol Ther 14(2):168–174CrossRef Daskalaki E, Prountzou A, Diem P, Mougiakakou SG (2012) Real-time adaptive models for the personalized prediction of glycemic profile in type 1 diabetes patients. Diabetes Technol Ther 14(2):168–174CrossRef
27.
go back to reference Dassau E, Cameron F, Bequette BW, Zisser H, Jovanovič L, Chase HP, Wilson DM, Buckingham BA, Doyle FJ (2010) Real-time hypoglycemia prediction suite using continuous glucose monitoring. Diabetes Care 33(6):1249–1254. doi:10.2337/dc09-1487 CrossRef Dassau E, Cameron F, Bequette BW, Zisser H, Jovanovič L, Chase HP, Wilson DM, Buckingham BA, Doyle FJ (2010) Real-time hypoglycemia prediction suite using continuous glucose monitoring. Diabetes Care 33(6):1249–1254. doi:10.​2337/​dc09-1487 CrossRef
28.
go back to reference Derouich M, Boutayeb A (2002) The effect of physical exercise on the dynamics of glucose and insulin. J Biomech 35:911–917CrossRef Derouich M, Boutayeb A (2002) The effect of physical exercise on the dynamics of glucose and insulin. J Biomech 35:911–917CrossRef
31.
go back to reference Elliott G, Granger CW, Timmermann A (eds) (2006) Handbook of economic forecasting, Chap. 10. Forecast combinations. Elsevier, Amsterdam Elliott G, Granger CW, Timmermann A (eds) (2006) Handbook of economic forecasting, Chap. 10. Forecast combinations. Elsevier, Amsterdam
32.
go back to reference Elton EJ, Gruber MJ, Padberg MW (1976) Simple criteria for optimal portfolio selection. J. Financ 31(5):1341–1357CrossRef Elton EJ, Gruber MJ, Padberg MW (1976) Simple criteria for optimal portfolio selection. J. Financ 31(5):1341–1357CrossRef
33.
go back to reference Eren-Oruklu M, Cinar A, Quinn L (2010) Hypoglycemia prediction with subject-specific recursive time-series models. J Diabetes Sci Technol 4(1):25–33CrossRef Eren-Oruklu M, Cinar A, Quinn L (2010) Hypoglycemia prediction with subject-specific recursive time-series models. J Diabetes Sci Technol 4(1):25–33CrossRef
35.
go back to reference Eren-Oruklu M, Cinar A, Quinn L, Smith D (2009) Estimation of future glucose concentrations with subject-specific recursive linear models. Diabetes Technol Ther 11(4):243–253. doi:10.1089/dia.2008.0065 CrossRef Eren-Oruklu M, Cinar A, Quinn L, Smith D (2009) Estimation of future glucose concentrations with subject-specific recursive linear models. Diabetes Technol Ther 11(4):243–253. doi:10.​1089/​dia.​2008.​0065 CrossRef
36.
go back to reference Estrada G, Kirchsteiger H, del Re L, Renard E (2010) Innovative approach for online prediction of blood glucose profile in type 1 diabetes patients. In: American control conference (ACC2010), pp 2015–2020 Estrada G, Kirchsteiger H, del Re L, Renard E (2010) Innovative approach for online prediction of blood glucose profile in type 1 diabetes patients. In: American control conference (ACC2010), pp 2015–2020
37.
38.
go back to reference Fabietti PG, Canonico V, Orsini-Federici M, Sarti E, Massi-Benedetti M (2007) Clinical validation of a new control-oriented model of insulin and glucose dynamics in subjects with type 1 diabetes. Diabetes Technol Ther 9(4):327–338. doi:10.1089/dia.2006.0030 CrossRef Fabietti PG, Canonico V, Orsini-Federici M, Sarti E, Massi-Benedetti M (2007) Clinical validation of a new control-oriented model of insulin and glucose dynamics in subjects with type 1 diabetes. Diabetes Technol Ther 9(4):327–338. doi:10.​1089/​dia.​2006.​0030 CrossRef
39.
go back to reference Farmer TG, Edgar TF, Peppas NA (2009) Effectiveness of intravenous infusion algorithms for glucose control in diabetic patients using different simulation models. Ind Eng Chem Res 48(9):4402–4414. doi:10.1021/ie800871t CrossRef Farmer TG, Edgar TF, Peppas NA (2009) Effectiveness of intravenous infusion algorithms for glucose control in diabetic patients using different simulation models. Ind Eng Chem Res 48(9):4402–4414. doi:10.​1021/​ie800871t CrossRef
40.
go back to reference Finan DA, Doyle FJ, Palerm CC, Bevier WC, Zisser HC, Jovanovic L, Seborg DE (2009) Experimental evaluation of a recursive model identification technique for type 1 diabetes. J Diabetes Sci Technol 3(5):1192–1202 Finan DA, Doyle FJ, Palerm CC, Bevier WC, Zisser HC, Jovanovic L, Seborg DE (2009) Experimental evaluation of a recursive model identification technique for type 1 diabetes. J Diabetes Sci Technol 3(5):1192–1202
41.
42.
go back to reference Gani A, Gribok AV, Rajaraman S, Ward WK, Reifman J (2009) Predicting subcutaneous glucose concentration in humans : data-driven glucose modeling. IEEE Trans Biomed Eng 56(2):246–254CrossRef Gani A, Gribok AV, Rajaraman S, Ward WK, Reifman J (2009) Predicting subcutaneous glucose concentration in humans : data-driven glucose modeling. IEEE Trans Biomed Eng 56(2):246–254CrossRef
43.
go back to reference Georga E, Protopappas V, Guillen A, Fico G, Ardigo D, Arredondo MT, Exar-chos TP, Polyzos D, Fotiadis DI (2009) Data mining for blood glucose prediction and knowledge discovery in diabetic patients: the METABO diabetes modeling and management system. Conference proceedings: annual international conference of the IEEE engineering in medicine and biology society. IEEE engineering in medicine and biology society. Conference 2009, pp 5633–5636. doi:10.1109/IEMBS.2009.5333635. http://www.ncbi.nlm.nih.gov/pubmed/19964403 Georga E, Protopappas V, Guillen A, Fico G, Ardigo D, Arredondo MT, Exar-chos TP, Polyzos D, Fotiadis DI (2009) Data mining for blood glucose prediction and knowledge discovery in diabetic patients: the METABO diabetes modeling and management system. Conference proceedings: annual international conference of the IEEE engineering in medicine and biology society. IEEE engineering in medicine and biology society. Conference 2009, pp 5633–5636. doi:10.​1109/​IEMBS.​2009.​5333635. http://​www.​ncbi.​nlm.​nih.​gov/​pubmed/​19964403
45.
go back to reference Georga EI, Protopappas VC, Fotiadis DI (2011) Glucose prediction in type 1 and type 2 diabetic patients using data driven techniques. In: Funatsu PK (ed) Knowledge-oriented applications in data mining, Chap. 17. InTech, Rijeka Georga EI, Protopappas VC, Fotiadis DI (2011) Glucose prediction in type 1 and type 2 diabetic patients using data driven techniques. In: Funatsu PK (ed) Knowledge-oriented applications in data mining, Chap. 17. InTech, Rijeka
46.
go back to reference Georga EI, Protopappas VC, Polyzos D, Fotiadis DI (2012) A predictive model of subcutaneous glucose concentration in type 1 diabetes based on random forests. In: 2012 annual international conference of the IEEE engineering in medicine and biology society (EMBC2012), pp 2889–2892 Georga EI, Protopappas VC, Polyzos D, Fotiadis DI (2012) A predictive model of subcutaneous glucose concentration in type 1 diabetes based on random forests. In: 2012 annual international conference of the IEEE engineering in medicine and biology society (EMBC2012), pp 2889–2892
47.
go back to reference Gustafsson F (2000) Adaptive filtering and change detection. Wiley, Hoboken Gustafsson F (2000) Adaptive filtering and change detection. Wiley, Hoboken
48.
go back to reference Hejlesen OK, Andreassen S, Hovorka R, Cavan D.A (1997) DIAS—the diabetes advisory system: an outline of the system and the evaluation results obtained so far. Comput Meth Prog Biomed 54(1–2):49–58 Hejlesen OK, Andreassen S, Hovorka R, Cavan D.A (1997) DIAS—the diabetes advisory system: an outline of the system and the evaluation results obtained so far. Comput Meth Prog Biomed 54(1–2):49–58
50.
go back to reference Hovorka R, Canonico V, Chassin LJ, Haueter U, Massi-Benedetti M, Federici MO, Pieber TR, Schaller HC, Schaupp L, Vering T, Wilinska ME (2004) Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes. Physiol Meas 25(4):905–920. doi:10.1088/0967-3334/25/4/010 CrossRef Hovorka R, Canonico V, Chassin LJ, Haueter U, Massi-Benedetti M, Federici MO, Pieber TR, Schaller HC, Schaupp L, Vering T, Wilinska ME (2004) Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes. Physiol Meas 25(4):905–920. doi:10.​1088/​0967-3334/​25/​4/​010 CrossRef
52.
go back to reference Jensen K, Pedersen C, Larsen L (2007) Diasnet mobile: a personalized mobile diabetes management and advisory service. In: 2nd workshop on personalization for e-health, vol 1 Jensen K, Pedersen C, Larsen L (2007) Diasnet mobile: a personalized mobile diabetes management and advisory service. In: 2nd workshop on personalization for e-health, vol 1
53.
go back to reference Johansson R (2009) System modeling & identification. KFS AB, Lund Johansson R (2009) System modeling & identification. KFS AB, Lund
54.
go back to reference Kanderian SS, Weinzimer S, Voskanyan G, Steil GM (2009) Identification of intraday metabolic profiles during closed-loop glucose control in individuals with type 1 diabetes. J Diab Sci Technol 3(5):1047–1057CrossRef Kanderian SS, Weinzimer S, Voskanyan G, Steil GM (2009) Identification of intraday metabolic profiles during closed-loop glucose control in individuals with type 1 diabetes. J Diab Sci Technol 3(5):1047–1057CrossRef
55.
go back to reference Kirchsteiger H, Estrada GC, Pölzer S, Renard E, Re L (2011) Estimating interval process models for type 1 diabetes for robust control design. In: IFAC world congress 2011, pp 11761–11766 Kirchsteiger H, Estrada GC, Pölzer S, Renard E, Re L (2011) Estimating interval process models for type 1 diabetes for robust control design. In: IFAC world congress 2011, pp 11761–11766
57.
go back to reference Kovatchev B, Breton C, Dalla-Man C, Cobelli C (2008) In silico model and computer simulation environment approximating the human glucose/insulin utilization. Technical Report. Food and Drug Administration Master File MAF 1521 Kovatchev B, Breton C, Dalla-Man C, Cobelli C (2008) In silico model and computer simulation environment approximating the human glucose/insulin utilization. Technical Report. Food and Drug Administration Master File MAF 1521
58.
go back to reference Kovatchev B, Straume M, Cox D, Farhy L (2000) Risk analysis of blood glucose data: a quantitative approach to optimizing the control of insulin dependent diabetes. J Theor Med 3:1–10MATHCrossRef Kovatchev B, Straume M, Cox D, Farhy L (2000) Risk analysis of blood glucose data: a quantitative approach to optimizing the control of insulin dependent diabetes. J Theor Med 3:1–10MATHCrossRef
59.
go back to reference Lee H, Buckingham BA, Wilson DM, Bequette BW (2009) A closed-loop artificial pancreas using model predictive control and a sliding meal size estimator. J Diabetes Sci Technol 3(5):1082–1090CrossRef Lee H, Buckingham BA, Wilson DM, Bequette BW (2009) A closed-loop artificial pancreas using model predictive control and a sliding meal size estimator. J Diabetes Sci Technol 3(5):1082–1090CrossRef
61.
go back to reference Lehmann ED (1994) AIDA: an interactive diabetes advisor. Comput Methods Programs Biomed 2607(93):183–203CrossRef Lehmann ED (1994) AIDA: an interactive diabetes advisor. Comput Methods Programs Biomed 2607(93):183–203CrossRef
62.
go back to reference Lehmann ED, Deutsch T (1992) A physiological model of glucose-insulin interaction in type 1 diabetes mellitus. J Biomed Eng 14:235–242CrossRef Lehmann ED, Deutsch T (1992) A physiological model of glucose-insulin interaction in type 1 diabetes mellitus. J Biomed Eng 14:235–242CrossRef
64.
go back to reference Lonergan T, Compte AL, Willacy M, Chase JG, Shaw GM, Hann CE, Lotz T, Lin J, Wong XW (2006) A pilot study of the SPRINT protocol for tight glycemic control in critically Ill patients. Diab Technol Ther 8(4):449–462. doi:10.1089/dia.2006.8.449 CrossRef Lonergan T, Compte AL, Willacy M, Chase JG, Shaw GM, Hann CE, Lotz T, Lin J, Wong XW (2006) A pilot study of the SPRINT protocol for tight glycemic control in critically Ill patients. Diab Technol Ther 8(4):449–462. doi:10.​1089/​dia.​2006.​8.​449 CrossRef
65.
go back to reference Lu Y, Rajaraman S, Ward WK, Vigersky RA, Reifman J (2011) Predicting human subcutaneous glucose concentration in real time: a universal data-driven approach. In: Proceedings of 2011 annual international conference of the IEEE engineering in medical and biology society (EMBC2011), pp 7945–7948. doi:10.1109/IEMBS.2011.6091959 Lu Y, Rajaraman S, Ward WK, Vigersky RA, Reifman J (2011) Predicting human subcutaneous glucose concentration in real time: a universal data-driven approach. In: Proceedings of 2011 annual international conference of the IEEE engineering in medical and biology society (EMBC2011), pp 7945–7948. doi:10.​1109/​IEMBS.​2011.​6091959
66.
go back to reference Makroglou A, Li J, Kuang Y (2006) Mathematical models and software tools for the glucose-insulin regulatory system and diabetes: an overview. Appl Num Math 56:559–573 Makroglou A, Li J, Kuang Y (2006) Mathematical models and software tools for the glucose-insulin regulatory system and diabetes: an overview. Appl Num Math 56:559–573
67.
go back to reference Man CD, Breton MD, Cobelli C (2009) Physical activity into the meal glucose-insulin model of type 1 diabetes: in silico studies. J Diab Sci Technol 3(1):56–67 Man CD, Breton MD, Cobelli C (2009) Physical activity into the meal glucose-insulin model of type 1 diabetes: in silico studies. J Diab Sci Technol 3(1):56–67
69.
go back to reference Natali A, Gastaldelli A, Camastra S, Sironi AM, Toschi E, Masoni A, Ferrannini E, Mari A (2000) Dose-response characteristics of insulin action on glucose metabolism: a nonsteady-state approach. Am J Physiol Endocrinol Metab 278(5):E794–E801 Natali A, Gastaldelli A, Camastra S, Sironi AM, Toschi E, Masoni A, Ferrannini E, Mari A (2000) Dose-response characteristics of insulin action on glucose metabolism: a nonsteady-state approach. Am J Physiol Endocrinol Metab 278(5):E794–E801
70.
go back to reference Naumova V, Pereverzyev S, Sampath S (2011) A meta-learning approach to the regularized learning—case study: blood glucose prediction. Technical Report. Johann Radon Institute for Computational and Applied Mathematics (RICAM), Linz, Austria Naumova V, Pereverzyev S, Sampath S (2011) A meta-learning approach to the regularized learning—case study: blood glucose prediction. Technical Report. Johann Radon Institute for Computational and Applied Mathematics (RICAM), Linz, Austria
71.
go back to reference Naumova V, Pereverzyev SV, Sivananthan S (2012) A meta-learning approach to the regularized learning-Case study: blood glucose prediction. Neural networks: the official journal of the International Neural Network Society 33:181–193. doi:10.1016/j.neunet.2012.05.004 MATHCrossRef Naumova V, Pereverzyev SV, Sivananthan S (2012) A meta-learning approach to the regularized learning-Case study: blood glucose prediction. Neural networks: the official journal of the International Neural Network Society 33:181–193. doi:10.​1016/​j.​neunet.​2012.​05.​004 MATHCrossRef
72.
go back to reference Nucci G, Cobelli C (2000) Models of subcutaneous insulin kinetics. A critical review. Comput Methods Programs Biomed 62:249–257CrossRef Nucci G, Cobelli C (2000) Models of subcutaneous insulin kinetics. A critical review. Comput Methods Programs Biomed 62:249–257CrossRef
73.
74.
go back to reference Oza N (2005) Online bagging and boosting. In: 2005 IEEE international conference on systems, man and cybernetics, vol 3, pp 2340–2345 Oza N (2005) Online bagging and boosting. In: 2005 IEEE international conference on systems, man and cybernetics, vol 3, pp 2340–2345
75.
go back to reference Palerm CC, Bequette BW (2007) Hypoglycemia detection and prediction using continuous glucose monitoring-a study on hypoglycemic clamp data. J Diabetes Sci Technol 1(5):624–629CrossRef Palerm CC, Bequette BW (2007) Hypoglycemia detection and prediction using continuous glucose monitoring-a study on hypoglycemic clamp data. J Diabetes Sci Technol 1(5):624–629CrossRef
76.
go back to reference Palerm CC, Willis JP, Desemone J, Bequette BW (2005) Hypoglycemia prediction and detection using optimal estimation. Diabetes Technol Ther 7(1):3–14CrossRef Palerm CC, Willis JP, Desemone J, Bequette BW (2005) Hypoglycemia prediction and detection using optimal estimation. Diabetes Technol Ther 7(1):3–14CrossRef
77.
go back to reference Pappada SM, Cameron BD, Rosman PM, Bourey RE, Papadimos TJ, Olorunto W, Borst MJ (2011) Neural network-based real-time prediction of glucose in patients with insulin- dependent diabetes. Diabetes Technol Ther 13(2):135–141CrossRef Pappada SM, Cameron BD, Rosman PM, Bourey RE, Papadimos TJ, Olorunto W, Borst MJ (2011) Neural network-based real-time prediction of glucose in patients with insulin- dependent diabetes. Diabetes Technol Ther 13(2):135–141CrossRef
78.
go back to reference Percival M, Bevier W, Wang Y (2010) Modeling the effects of subcutaneous insulin administration and carbohydrate consumption on blood glucose. J Diabetes 39(3):800–805 Percival M, Bevier W, Wang Y (2010) Modeling the effects of subcutaneous insulin administration and carbohydrate consumption on blood glucose. J Diabetes 39(3):800–805
79.
go back to reference Percival M, Wang Y, Grosman B, Dassau E, Zisser H, Jovanovič L, Doyle F (2011) Development of a multi-parametric model predictive control algorithm for insulin delivery in type 1 diabetes mellitus using clinical parameters. J Proc Control 21(3):391–404. doi:10.1016/j.jprocont.2010.10.003 CrossRef Percival M, Wang Y, Grosman B, Dassau E, Zisser H, Jovanovič L, Doyle F (2011) Development of a multi-parametric model predictive control algorithm for insulin delivery in type 1 diabetes mellitus using clinical parameters. J Proc Control 21(3):391–404. doi:10.​1016/​j.​jprocont.​2010.​10.​003 CrossRef
80.
go back to reference Pérez-Gandía C, Facchinetti A, Sparacino G, Cobelli C, Gómez EJ, Rigla M, Leiva AD, Hernando ME (2010) Artificial neural network algorithm for online glucose. Diabetes Technol Ther 12(1):81–88CrossRef Pérez-Gandía C, Facchinetti A, Sparacino G, Cobelli C, Gómez EJ, Rigla M, Leiva AD, Hernando ME (2010) Artificial neural network algorithm for online glucose. Diabetes Technol Ther 12(1):81–88CrossRef
81.
go back to reference Plougmann SR, Hejlesen O, Turner B, Kerr D, Cavan D (2003) The effect of alcohol on blood glucose in type 1 diabetes metabolic modelling and integration in a decision support system. Int J Med Inf 70(2–3):337–344. doi:10.1016/S1386-5056(03)00038-8 Plougmann SR, Hejlesen O, Turner B, Kerr D, Cavan D (2003) The effect of alcohol on blood glucose in type 1 diabetes metabolic modelling and integration in a decision support system. Int J Med Inf 70(2–3):337–344. doi:10.​1016/​S1386-5056(03)00038-8
82.
go back to reference Poulsen J, Avogaro A, Chauchard F, Cobelli C, Johansson R, Nita L, Pogose M, del Re L, Renard E, Sampath S, Saudek F, Skillen M, Soendergaard J (2010) A diabetes management system empowering patients to reach optimised glucose control: from monitor to advisor. In: Proceedings of 2010 annual international conference of the IEEE engineering in medical and biology society (EMBC2010), pp 5270–5271. doi:10.1109/IEMBS.2010.5626313 Poulsen J, Avogaro A, Chauchard F, Cobelli C, Johansson R, Nita L, Pogose M, del Re L, Renard E, Sampath S, Saudek F, Skillen M, Soendergaard J (2010) A diabetes management system empowering patients to reach optimised glucose control: from monitor to advisor. In: Proceedings of 2010 annual international conference of the IEEE engineering in medical and biology society (EMBC2010), pp 5270–5271. doi:10.​1109/​IEMBS.​2010.​5626313
83.
go back to reference Prigeon RL, Røder ME, Porte D, Kahn SE (1996) The effect of insulin dose on the measurement of insulin sensitivity by the minimal model technique. Evidence for saturable insulin transport in humans. J Clin Invest 97(2):501–507. doi:10.1172/JCI118441 CrossRef Prigeon RL, Røder ME, Porte D, Kahn SE (1996) The effect of insulin dose on the measurement of insulin sensitivity by the minimal model technique. Evidence for saturable insulin transport in humans. J Clin Invest 97(2):501–507. doi:10.​1172/​JCI118441 CrossRef
84.
go back to reference Puckett WR (1992) Dynamic modeling of diabetes mellitus. PhD thesis. University ofWisconsin- Madison Puckett WR (1992) Dynamic modeling of diabetes mellitus. PhD thesis. University ofWisconsin- Madison
85.
go back to reference Raftery AE, Gneiting T, Balabdaoui F, Pololakowski M (2005) Using Bayesian model averaging to calibrate forecast ensembles. Mon Weather Rev 133:1155–1174CrossRef Raftery AE, Gneiting T, Balabdaoui F, Pololakowski M (2005) Using Bayesian model averaging to calibrate forecast ensembles. Mon Weather Rev 133:1155–1174CrossRef
86.
go back to reference Raftery AE, Kárný M, Ettler P (2010) Online prediction under model uncertainty via dynamic model averaging: application to a cold rolling mill. Technometrics 52(1):52–66MathSciNetCrossRef Raftery AE, Kárný M, Ettler P (2010) Online prediction under model uncertainty via dynamic model averaging: application to a cold rolling mill. Technometrics 52(1):52–66MathSciNetCrossRef
87.
go back to reference Rebrin K, Steil GM (2000) Can interstitial glucose assessment replace blood glucose measurements? Diabetes Technol Ther 2(3):461–472CrossRef Rebrin K, Steil GM (2000) Can interstitial glucose assessment replace blood glucose measurements? Diabetes Technol Ther 2(3):461–472CrossRef
88.
go back to reference Rizza R, Mandarino LJ, Gerich JE (1981) Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Phys Endocrinol Metab 240(6):E630–E639 Rizza R, Mandarino LJ, Gerich JE (1981) Dose-response characteristics for effects of insulin on production and utilization of glucose in man. Am J Phys Endocrinol Metab 240(6):E630–E639
89.
go back to reference Roy A, Parker RS (2006) Dynamic modeling of free fatty acid, glucose, and insulin: an extended minimal model. Diab Technol Ther 8(6):617–626CrossRef Roy A, Parker RS (2006) Dynamic modeling of free fatty acid, glucose, and insulin: an extended minimal model. Diab Technol Ther 8(6):617–626CrossRef
90.
go back to reference Roy A, Parker RS (2006) Mixed meal modeling and disturbance rejection in type I diabetes patients. In: Proceedings of 28th IEEE EMBS annual international conference, pp 323–326 Roy A, Parker RS (2006) Mixed meal modeling and disturbance rejection in type I diabetes patients. In: Proceedings of 28th IEEE EMBS annual international conference, pp 323–326
91.
go back to reference Roy A, Parker RS (2007) Dynamic modeling of exercise effects on plasma glucose and insulin levels. J Diabetes Sci Technol 1(3):338–347CrossRef Roy A, Parker RS (2007) Dynamic modeling of exercise effects on plasma glucose and insulin levels. J Diabetes Sci Technol 1(3):338–347CrossRef
92.
go back to reference Salzsieder E, Albrecht G, Fischer U, Freyse EJ (1985) Kinetic modeling of the glucoregulatory system to improve insulin therapy. IEEE Trans Biomed Eng BME-32(10):846–855 Salzsieder E, Albrecht G, Fischer U, Freyse EJ (1985) Kinetic modeling of the glucoregulatory system to improve insulin therapy. IEEE Trans Biomed Eng BME-32(10):846–855
94.
go back to reference Schvarcz E, Palmer M, Aman J, Horowitz M, Stridsberg M, Berne C (1997) Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 113(1):60–66CrossRef Schvarcz E, Palmer M, Aman J, Horowitz M, Stridsberg M, Berne C (1997) Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 113(1):60–66CrossRef
95.
go back to reference Sorensen JT (1985) A physiologic model of glucose metabolism in man and its use to design and assess improved insulin therapies for diabetes. PhD thesis. Massachusetts Institute of Technology Sorensen JT (1985) A physiologic model of glucose metabolism in man and its use to design and assess improved insulin therapies for diabetes. PhD thesis. Massachusetts Institute of Technology
96.
go back to reference Sparacino G, Zanderigo F, Corazza S, Maran A, Fachinetti A, Cobelli C (2007) Glucose concentration can be predicted ahead in time from continuous glucose monitoring sensor time-series. IEEE Trans Biomed Eng 54(5):931–937CrossRef Sparacino G, Zanderigo F, Corazza S, Maran A, Fachinetti A, Cobelli C (2007) Glucose concentration can be predicted ahead in time from continuous glucose monitoring sensor time-series. IEEE Trans Biomed Eng 54(5):931–937CrossRef
97.
go back to reference Ståhl F (2003) Diabetes mellitus modelling based on blood glucose measurements. Master Thesis TFRT-5703, Department of Automatic Control, Lund University, Sweden Ståhl F (2003) Diabetes mellitus modelling based on blood glucose measurements. Master Thesis TFRT-5703, Department of Automatic Control, Lund University, Sweden
98.
go back to reference Ståhl F (2012) Diabetes mellitus glucose prediction by linear and Bayesian ensemble modeling. Licentiate Thesis TFRT–3255, Department of Automatic Control, Lund University, Sweden (2012) Ståhl F (2012) Diabetes mellitus glucose prediction by linear and Bayesian ensemble modeling. Licentiate Thesis TFRT–3255, Department of Automatic Control, Lund University, Sweden (2012)
99.
go back to reference Ståhl F, Johansson R (2009) Diabetes mellitus modeling and short-term prediction based on blood glucose measurements. Math Biosci 217:101–117MATHMathSciNetCrossRef Ståhl F, Johansson R (2009) Diabetes mellitus modeling and short-term prediction based on blood glucose measurements. Math Biosci 217:101–117MATHMathSciNetCrossRef
100.
go back to reference Takagi T, Sugeno M (1985) Fuzzy identification of system and its applications to modelling and control. IEEE Trans Syst Man Cybern SMC-15:116–132 Takagi T, Sugeno M (1985) Fuzzy identification of system and its applications to modelling and control. IEEE Trans Syst Man Cybern SMC-15:116–132
101.
go back to reference Vaddiraju S, Burgess DJ, Tomazos I, Jain FC, Papadimitrakopoulos F (2010) Technologies for continuous glucose monitoring: current problems and future promises. J Diabetes Sci Technol 4(6):1540–1562CrossRef Vaddiraju S, Burgess DJ, Tomazos I, Jain FC, Papadimitrakopoulos F (2010) Technologies for continuous glucose monitoring: current problems and future promises. J Diabetes Sci Technol 4(6):1540–1562CrossRef
102.
go back to reference Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M (2001) Vlas-selaers D, Ferdinande P, Lauwers P, Bouillon R (2001) Intensive insulin therapy in critically ill patients. N Engl J Med 345(19):1359–1367CrossRef Van den Berghe G, Wouters P, Weekers F, Verwaest C, Bruyninckx F, Schetz M (2001) Vlas-selaers D, Ferdinande P, Lauwers P, Bouillon R (2001) Intensive insulin therapy in critically ill patients. N Engl J Med 345(19):1359–1367CrossRef
103.
go back to reference Wilinska ME, Chassin LJ, Acerini CL, Allen JM, Dunger DB, Hovorka R (2010) Simulation environment to evaluate closed-loop insulin delivery systems in type 1 diabetes. J Diab Sci Technol 4(1):132–144CrossRef Wilinska ME, Chassin LJ, Acerini CL, Allen JM, Dunger DB, Hovorka R (2010) Simulation environment to evaluate closed-loop insulin delivery systems in type 1 diabetes. J Diab Sci Technol 4(1):132–144CrossRef
104.
go back to reference Wilinska ME, Chassin LJ, Schaller HC, Schaupp L, Pieber TR, Hovorka R (2005) Insulin kinetics in type-1 diabetes: continuous and bolus delivery of rapid acting insulin. IEEE Trans Biomed Eng 52(1):3–12CrossRef Wilinska ME, Chassin LJ, Schaller HC, Schaupp L, Pieber TR, Hovorka R (2005) Insulin kinetics in type-1 diabetes: continuous and bolus delivery of rapid acting insulin. IEEE Trans Biomed Eng 52(1):3–12CrossRef
105.
go back to reference Worthington DRL (1997) Minimal model of food absorbtion in the gut. Med Inform 22(1):35–45CrossRef Worthington DRL (1997) Minimal model of food absorbtion in the gut. Med Inform 22(1):35–45CrossRef
106.
go back to reference Zecchin C, Facchinetti A, Sparacino G, De Nicolao G, Cobelli C (2011) A new neural network approach for short-term glucose prediction using continuous glucose monitoring time-series and meal information. 2011 annual international conference of the IEEE engineering in medical and biology society (EMBC2011), pp 5653–5656. doi:10.1109/IEMBS.2011.6091368 Zecchin C, Facchinetti A, Sparacino G, De Nicolao G, Cobelli C (2011) A new neural network approach for short-term glucose prediction using continuous glucose monitoring time-series and meal information. 2011 annual international conference of the IEEE engineering in medical and biology society (EMBC2011), pp 5653–5656. doi:10.​1109/​IEMBS.​2011.​6091368
Metadata
Title
Ensemble Glucose Prediction in Insulin-Dependent Diabetes
Authors
Fredrik Ståhl
Rolf Johansson
Eric Renard
Copyright Year
2014
Publisher
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-642-54464-4_2