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2020 | OriginalPaper | Chapter

Evaluation of the Quercetin Semisynthetic Derivatives Interaction with ABCG2 and Cyclooxygenase-2

Author : A. E. Manukyan

Published in: 4th International Conference on Nanotechnologies and Biomedical Engineering

Publisher: Springer International Publishing

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Abstract

Cancer multiple drug resistance and the inflammatory process are the main problems for successful chemotherapy. In anticancer therapy, plant and semisynthetic compounds are considered as potential modifiers for ABCG2 and COX2 inhibitors. As a result of experiments carried out in silico, the possible interaction of ABCG2 and inhibition of COX-2 by semisynthetic derivatives of quercetin were first revealed. The physicochemical parameters of the studied ligands were revealed, after which, for reliability, they were compared with in vitro experiments.

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Title: Evaluation of the Quercetin Semisynthetic Derivatives Interaction with ABCG2 and Cyclooxygenase-2
Author: A. E. Manukyan
Publisher: Springer International Publishing
Book: 4th International Conference on Nanotechnologies and Biomedical Engineering
Print ISBN: 978-3-030-31865-9

Electronic ISBN: 978-3-030-31866-6

Copyright Year: 2020
DOI: https://doi.org/10.1007/978-3-030-31866-6_98