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Published in:
2014 | OriginalPaper | Chapter
Evolution of Genes Neighborhood within Reconciled Phylogenies: An Ensemble Approach
Authors : Cedric Chauve, Yann Ponty, João Paulo Pereira Zanetti
Published in: Advances in Bioinformatics and Computational Biology
Publisher: Springer International Publishing
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We consider a recently introduced dynamic programming scheme to compute parsimonious evolutionary scenarios for gene adjacencies. We extend this scheme to sample evolutionary scenarios from the whole solution space under the Boltzmann distribution. We apply our algorithms to a dataset of mammalian gene trees and adjacencies, and observe a significant reduction of the number of syntenic inconsistencies observed in the resulting ancestral gene adjacencies.