Experimental Investigation of a Single Molecule Detection in Thermoplastics

Nowadays, the research work has been more focused in developing the techniques on novel nanochannel fabrication. The techniques developed are either time consuming or expensive. One of the techniques in developing this type is by generating the sub-micrometer wide channels in thermoplastic chips. We can apply this technique in single molecule detection. For this, a mechanical rig was designed and subjected to strain to produce thermomechanical deformation in thermoplastic micro-channel cell. To optimize the initial and micro-channel dimensions, a rectangular micro-type of channels with different sizes and shapes was deformed. To reach sub-micrometer widths, the height and width of the channels designed should be with low aspect ratios with less initial dimensions. The manufacturing and assembly tolerances are affecting the nano-channels fabrication.