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2022 | OriginalPaper | Chapter

Fabrication and Characterization of Porous Flow-Assembled Chitosan Membranes in Microfluidics

Authors : Khanh L. Ly, Xiaolong Luo

Published in: 8th International Conference on the Development of Biomedical Engineering in Vietnam

Publisher: Springer International Publishing

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Abstract

The aim of this research is to customize the porosity of biofabricated chitosan membrane (CM) employing co-assembled polystyrene nanoparticles (np) as a sacrificial template. CM with np (CM-np) was manufactured inside the microfluidic chip using the flow-assembly technique. Glutaraldehyde was used to crosslink the fabricated CM-np were then dissolved with dimethyl sulfoxide, leaving the porous chitosan membrane (pCM). The growth rate of CM and CM-np was investigated to determine the effects of np incorporation on the growth of the fabricated membrane. The morphology of the biofabricated CM and pCM were evaluated using scanning electron microscopy. The mass transport tests were also conducted to confirm the increase in pores size of pCM in comparison with pure CM. Thus, in this study, we have demonstrated the capability to manipulate the porosity of the biofabricared CM manufactured by flows inside microfluidic chips and characterized the properties of the fabricated membranes. This tuning process is promising and can enhance the applicability of biopolymer CM in biochemistry and biology researches.

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Title: Fabrication and Characterization of Porous Flow-Assembled Chitosan Membranes in Microfluidics
Authors: Khanh L. Ly
Xiaolong Luo
Publisher: Springer International Publishing
Book: 8th International Conference on the Development of Biomedical Engineering in Vietnam
Print ISBN: 978-3-030-75505-8

Electronic ISBN: 978-3-030-75506-5

Copyright Year: 2022
DOI: https://doi.org/10.1007/978-3-030-75506-5_31

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