Top

Published in:

2017 | OriginalPaper | Chapter

11. Future Perspectives of Bioactive Glasses for the Clinical Applications

Authors : V. Kumar, G. Pickrell, S.G. Waldrop, N. Sriranganathan

Published in: Bioactive Glasses

Publisher: Springer International Publishing

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Tissue engineering is continuously evolving as an exciting and multidisciplinary field aiming to develop biological substitutes to restore, replace, or regenerate defective tissues. Scaffolds, cells, and growth-stimulating signals are the basic components of tissue engineering. However, researchers often encounter an enormous variety of choices when selecting scaffolds for tissue engineering. Typically, glass, ceramics, or polymeric biomaterials are used for making scaffolds, which provide the structural support for cell attachment and subsequent tissue development.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

previous chapter Bulk Metallic GlassesBulk Metallic Glasses for Healthcare: State of the Art and Prospects for the Future

Denrya I, Liisa T (2016) Kuhn design and characterization of calcium phosphate ceramic scaffolds for bone tissue engineering. Dent Mater 32:43–53

Bakry AS, Takahashid H, Otsukie M, Tagamie J (2014) Evaluation of new treatment for incipient enamel demineralization using 45S5 bioglass. Oper Dent Mater 30:314–320

Tulyaganova DU, Reddy AA, Siegelc R, Ionescud E, Riedeld R, Ferreira JMF (2015) Synthesis and in vitro bioactivity assessment of injectable bioglass_organic pastes for bone tissue repair. Ceram Int 41:9373–9382

Renghini C, Giuliani A, Mazzoni S, Brun F, Larsson E, Baino F et al (2013) Microstructural characterization and in vitro bioactivity of porous glass ceramic scaffolds for bone regeneration by synchrotron radiation X-ray microtomography. J Eur Ceram Soc 33:1553–1565

Rahaman MN et al (2014) Mater Sci Eng C 41:224–231

Larrañaga A, Diamanti E, Rubio E, Palomares T, Alonso-Varona A, Aldazabal P, Martin FJ, Sarasua JR (2014) A study of themechanical properties and cytocompatibility of lactide and caprolactone based scaffolds filled with inorganic bioactive particles. Mater Sci Eng C 42:451–460

Gentile P, Bellucci D, Sola A, Matt C, Cannillo V, Ciardelli G (2015) Composite scaffolds for controlled drug release: role of the polyurethane nanoparticles on the physical properties andcell behavior. J Mech Behav Biomater 44:53–60

Chan BP, Leong KW (2008) Scaffolding in tissue engineering: general approaches and tissue-specific considerations. Eur Spine J 17(4):467–479

Bellucci D, Cannillo V, Sola A (2011a) Calcium and potassium addition to facilitate the sintering of bioactive glasses. Mater Lett 65:1825–1827

Bellucci D, Sola A, Cannillo V, (2012b) Low temperature sintering of innovative bioactive glasses. J Am Ceram Soc 95:1313–1319

Bellucci D, Sola A, Cannillo V (2013a) Bioactive glass-based composites for the production of dense sintered bodies and porous scaffolds. Mater Sci Eng C Mater Biol Appl 33:2138–2151

Idowu B, Cama G, Deb S, DiSilvio L (2014) In vitro osteoinductive potential of porous monetite for bone tissue engineering. J Tissue Eng 5:1–14 (2041731414536572)

Blaker J, Maquet V, Jérome R, Boccaccini AR, Nazhat SN (2005) Mechanical properties of highly porous PDLLA/bioglass composite foams as scaffolds for bone tissue engineering. Acta Biomater 1:643–652

Soundrapandiana C, Mahatob A, Kundu B, Datta S, Sac B, Basu D (2014) Development and effect of different bioactive silicate glass scaffolds: invitro evaluation for use as a bone drug delivery system. J Mech Behav Biomater 40:1–1 2

Rosenqvist K, Airaksinen S, Vehkamäki M, Juppo AM (2014) Evaluating optimal combination of clodronate and bioactive glass for dental application. Int J Pharm 468:112–120

Bakry AS, Takahashi H, Otsuki M, Sadr A, Yamashita K, Tagami J (2011) CO₂ laser improves 45S5 bioglass interaction withdentin. J Dent Res 90(2):246–250

Baino F, Brovarone CV (2014) Bioceramics in ophthalmology. Acta Biomater 10:3372–3397

Kinnunen I, Aitasalo K, Pollonen M, Varpula M (2000) Reconstruction of orbital fractures using bioactive glass. J Craniomaxollofac Surg 28:229–234

Peltola M, Kinnunen I, Aitasalo K (2008) Reconstruction of orbital wall defects with bioactive glass plates. J Oral Maxillofac Surg 66:639–646

Chirila TV (2001) An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application. Biomaterials 22:3311–3317

Linnola RJ, Happonen RP, Andersson OH, Vedel EA, Yli-Urpo U, Krause U et al (1996) Titanium and bioactive glass-ceramic coated titanium as materials for keratoprosthesis. Exp Eye Res 63:471–478

Tulyaganov DU, Agathopoulos S, Valerio P, Balamurugan A, Saranti A, Karakassides MA, Ferreira JM (2011) Synthesis, bioactivity and preliminary biocompatibility studies of glasses in the system CaO–MgO–SiO₂–Na₂O–P₂O₅–CaF₂. J Mater Sci Mater Med 22:217–227

Tulyaganov DU, Makhkamov ME, Urazbaev A, Goel A, Ferreira JMF (2013) Synthesis, processing and characterization of a bioactive glass composition for bone regeneration. Ceram Int 39:2519–2526

Arcos D, Regí MV (2010) Sol–gel silica-based biomaterials and bone tissue regeneration. Acta Biomater 6:2874–2888

Bellantone M, Coleman NJ, Hench LL (2000) Bacteriostatic action of a novel four component bioactive glass. J Biomed Mater Res 51:484–490

Rezwan K, Chen QZ, Blaker J, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27:3413–3431

Fu Q, Saiz E, Rahaman MN, Tomsia AP (2011) Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. Mater Sci Eng C 31:1245–1256

Thomson RC, Yaszemski MJ, Power JM, Mikos AG (1998) Hydroxyapatite fiber reinforced poly(α-hydroxy ester) foams for bone regeneration. Biomaterials 19:1935–1943

Roether JA, Boccaccini AR, Hench LL, Maquet V, Gautier S, Jérome R (2002) Development and in vitro characterization of novel bioresorbable and bioactive composite materials based on polylactide foams and bioglassfor tissue engineering applications. Biomaterials 23:3871–3878

Maquet V, Boccaccini AR, Pravata L, Notingher I, Jérome R (2004) Porous poly (α-hydroxyacid)/bioglass composite scaffolds for bone tissue engineering I: preparation and in vitro characterization. Biomaterials 25:4185–4194

Chen JP, Chang YS (2011) Preparation and characterization of composite nanofibers of polycaprolactone and nanohydroxyapatite for osteogenic differentiationof mesenchymal stem cells. Colloids Surf B: Biointerfaces 86:169–175

Kim SS, Park MS, Jeon O, Choi CY, Kim BS (2006) Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering. Biomaterials 27:1399–1409

Kim HW, Lee HH, Chun GS (2008) Bioactivity and osteoblast responses of novel biomedical nanocomposites of bioactive glass nanofiber filled poly(lactic acid) J Biomed Mater Res Part A 85:651–663

Gerhardt LC, Boccaccini AR (2010) Bioactive glass and glass-ceramic scaffolds for bone tissue engineering. Materials 3:3867–3910

Rahaman MN, Day DE, Bal BS, Fu Q, Jung SB, Bonewald LF, Tomsia AP (2011) Bioactive glass in tissue engineering. Acta Biomater 7:2355–2373

Lee J, Guarino V, Gloria A, Ambrosio L, Tae G, Kim et al YH (2010) Regeneration of Achilles’ tendon: the role of dynamic stimulation for enhanced cell proliferation and mechanical properties. J Biomater Sci 21:1173–1190

Jeong SI, Kim SH, Kim YH, Jung Y, Kwon JH, Kim et al BS (2004) Manufacture of elastic biodegradable PLCL scaffolds for mechano-active vascular tissue engineering. J Biomater Sci Polym Ed 15:645–660

Calori GM, Mazza E, Colombo M, Ripamonti C (2011) The use of bone-graft substitutes in large bone defects: any specific needs? Injury—Int J Care Inj 42:56–63

Albrektsson T, Johansson C. Osteoinduction (2001) Osteoconduction and osseointegration. Eur Spine J 10:96–101

Minardi S, Corradetti B, Taraballi F et al (2015) Evaluation of the osteoinductive potential of a bio-inspired scaffold mimicking the osteogenic niche for bone augmentation. Biomaterials 62:128–137

Wang L, Zhang B, Bao C et al (2014) Ectopic osteoid and bone formation by three calcium-phosphate ceramics in rats, rabbits and dogs. PLoS One 9(9):e107044

Daculsi G, Fellah BH, Miramond T (2014) The essential role of calcium phosphate bioceramics in bone regeneration. In: BenNissan B (ed), Advances in calcium phosphate biomaterials, Springer-Verlag, Berlin, pp 71–96

Landi E, Logroscino G, Proietti L et al (2008) Biomimetic Mg-substituted hydroxyapatite: from synthesis to in vivo behaviour. J Mater Sci Mater Med 19(1):239–247

Maier JAM, Bernardini D, Rayssiguier Y, Mazur A (2004) High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro. Biochim Biophys Acta—Mol Basis Dis 1689(1):6–12

Marie PJ, Ammann P, Boivin G, Rey C (2001) Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 69(3):121–129

Marquis P, Roux C, Diaz-Curiel M et al (2007) Long-term beneficial effects of strontium ranelate on the quality of life in patients with vertebral osteoporosis (Soti study). Calcif Tissue Int 80:137–138

Ortolani S, Vai S (2006) Strontium ranelate: an increased bone quality leading to vertebral antifracture efficacy at all stages. Bone 38(2):19–22

Pors Nielsen S (2004) The biological role of strontium. Bone 35(3):583–588

Li H, Chang J (2013) Bioactive silicate materials stimulate angiogenesis in fibroblast and endothelial cell co-culture system through paracrine effect. Acta Biomater 9(6):6981–6991

Pietak AM, Reid JW, Stott MJ, Sayer M (2007) Silicon substitution in the calcium phosphate bioceramics. Biomaterials 28(28):4023–4032

Schwartzwalder K, Somers AV (1963) Inventors. General motors corporation, assignee. Method of making porous ceramic articles. US patent 3,090,094

Chang BS, Lee CK, Hong KS et al (2000) Osteoconduction at porous hydroxyapatite with various pore configurations. Biomaterials 21(12):1291–1298

Saiz E, Gremillard L, Menendez G et al (2007) Preparation of porous hydroxyapatite scaffolds. Mater Sci Eng C-Biomim Supramol Syst 27(3):546–550

Tian JT, Tian JM (2001) Preparation of porous hydroxyapatite. J Mater Sci 36(12):3061–3066

Padilla S, Sanchez-Salcedo S, Vallet-Regi M (2007) Bioactive glass as precursor of designed-architecture scaffolds for tissue engineering. J Biomed Mater Res Part A 81(1):224–232

Santos JD, Knowles JC, Reis RL, Monteiro FJ, Hastings GW (1994) Microstructural characterization of glass-reinforced hydroxyapatite composites. Biomaterials 15(1):5–10

Colombo P, Hellmann JR (2002) Ceramic foams from preceramic polymers. Mater Res Innov 6(5–6):260–272

Shepherd JH, Best SM (2011) Calcium phosphate scaffolds for bone repair. JOM 63(4):83–92

Lewis JA, Smay JE (2005) Three-dimensional periodic structures. Cell Ceram Struct Manuf Properties Appl pp 87–100

Lewis JA, Smay JE, Stuecker J, Cesarano III J (2006) Direct ink writing of three-dimensional ceramic structures. J Am Ceram Soc 89(12):3599–3609

Simon JL, Michna S, Lewis JA et al (2007) In vivo bone response to 3D periodic hydroxyapatite scaffolds assembled by direct ink writing. J Biomed Mater Res Part A 83(3):747–758

Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21(24):2529–2543

Descamps M, Duhoo T, Monchau F et al (2008) Manufacture of macroporous beta-tricalcium phosphate bioceramics. J Eur Ceram Soc 28(1):149–157

Descamps M, Richart O, Hardouin P, Hornez JC, Leriche A (2008) Synthesis of macroporous beta-tricalcium phosphate with controlled porous architectural. Ceram Int 34(5):1131–1137

Michna S, Wu W, Lewis JA (2005) Concentrated hydroxyapatite inks for direct-write assembly of 3-D periodic scaffolds. Biomaterials 26(28):5632–5639

Denry I, Holloway JA (2014) Low temperature sintering of fluorapatite glass-ceramics. Dental Mater 30(2):112–121

Fu Q, Saiz E, Rahaman MN, Tomsia AP (2011) Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives. Mater Sci Eng C—Mater Biol Appl 31(7):1245–1256

Barrere F, Mahmood TA, de Groot K, van Blitterswijk CA (2008) Advanced biomaterials for skeletal tissue regeneration: Instructive and smart functions. Mater Sci Eng R Rep 59(1–6):38–71

Barrere F, van Blitterswijk CA, de Groot K (2006) Bone regeneration: molecular and cellular interactions with calcium phosphate ceramics. Int J Nanomed 1(3):317–332

Davies JE (2007) Bone bonding at natural and biomaterial surfaces. Biomaterials 28(34):5058–5067

Woodard JR, Hilldore AJ, Lan SK et al (2007) The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity. Biomaterials 28(1):45–54

Diaz-Rodriguez P, Gonzalez P, Serra J, Landin M (2014) Key parameters in blood-surface interactions of 3D bioinspired ceramic materials. Mater Sci Eng C-Mater Biol Appl 41:232–239

Seyfert UT, Biehl V, Schenk J (2002) In vitro hemocompatibility testing of biomaterials according to the ISO 10993–4. Biomol Eng 19(2–6):91–96

ISO (2002) Standard 10993-4 Biological evaluation of medical devices—part 4: selection of tests for interactions with blood

LeGeros RZ (2002) Properties of osteoconductive biomaterials: calcium phosphates. Clin Orthop Relat Res 395:81–98

Autefage H, Briand-Mesange F, Cazalbou S et al (2009) Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/beta-tricalcium phosphate porous ceramics. J Biomed Mater Res B Appl Biomater 91(2):706–715

Liu Y, de Groot K, Hunziker EB (2005) BMP-2 liberated from biomimetic implant coatings induces and sustains direct ossification in an ectopic rat model. Bone 36(5):745–757

Roldan JC, Detsch R, Schaefer S et al (2010) Bone formation and degradation of a highly porous biphasic calcium phosphate ceramic in presence of BMP-7, VEGF and mesenchymal stem cells in an ectopic mouse model. J Craniomaxillofac Surg 38(6):423–430

Guicheux J, Gauthier O, Aguado E et al (1998) Human growth hormone locally released in bone sites by calcium-phosphate biomaterial stimulates ceramic bone substitution without systemic effects: a rabbit study. J Bone Miner Res 13(4):739–748

Thomson RC, Yaszemski MJ, Power JM, Mikos AG (1998) Hydroxyapatite fiber reinforced poly(α-hydroxy ester) foams for bone regeneration. Biomaterials 19:1935–1943.

Lee J, Guarino V, Gloria A, Ambrosio L, Tae G, Kim YH (2010) Regeneration of Achilles’ tendon: the role of dynamic stimulation for enhanced cell proliferation and mechanical properties. J Biomater Sci 21:1173–1190

Jeong SI, Kim SH, Kim YH, Jung Y, Kwon JH, Kim BS et al (2004) Manufacture of elastic biodegradable PLCL scaffolds for mechano-active vascular tissue engineering. J Biomater Sci Polym Ed 15:645–660

Yunos DM, Bretcanu O, Boccaccini A (2008) Polymer–bioceramic composites for tissue engineering scaffolds. J Mater Sci Mater Med 43:4433–4442

Yagmurlu MF, Korkusuz F, Guersel I, Korkusuz P, Ors U, Hasirci V (1999) Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic delivery system: in vivo effectiveness and biocompatibility in the treatment of implant-related experimental osteomyelitis. J Biomed Mater Res 46:494–503

Zhang X, Wyss UP, Pichora D, GoosenMF (1994a) Biodegradable controlled antibiotic release devices for osteomyelitis: optimization of release properties.J Pharm Pharmacol 46:718–724

Zhang X, Wyss UP, Pichora D, Goosen MFA (1994b) Amechanistic study of antibiotic release from biodegradable poly (d, 1-lactide)cylinders. J Control Release 31:129–144

Domingues ZR, Cortés, ME, Gomes TA, Diniz HF, Freitas CS, Gomes JB, Faria AMC, Sinisterra RD (2004) Bioactive glass as a drug delivery system of tetracycline and tetracycline associated with β-cyclodextrin. Biomaterials 25:327–333

Czarnobaj K (2008) Preparation and characterization of silica xerogels as carriers for drugs. Drug Deliv 15:485–492

Merchant HA, Shoaib HM, Tazeen J, Yousuf RI (2006) Once- daily tablet formulation and in vitro release evaluation of cefpodoxime using hydroxypropyl methylcellulose: a technical note. AAPS PharmSciTech 7:78

Bang H-G, Kim S-J, Park S-Y (2008) Biocompatibilityandthe physicalpropertiesofbio-glassceramicsinthe Na₂O–CaO–SiO₂–P₂O₅ system withCaF₂ and MgF₂ additives. J Ceram Proc Res 9:588–590

Aina V, Malavasi G, Fiorio Pla A, Munaron L, Morterra C (2009) Zinc-containing bioactive glasses: surface reactivity and behaviour towards endothelial cells. Acta Biomater 5:1211–1222

Ma ZJ, Yamaguchi M (2001) Role of endogenous zinc in the enhancement of bone protein synthesis associated with bone growth of newborn rats. J Bone Miner Metab 19:38–44

Xia W, Chang J (2006) Well-ordered mesoporous bioactive glasses (MBG): a promising bioactive drug delivery system. J Control Release 110:522–530

Kundu B, Soundrapandian C, Nandi SK, Mukherjee P, Dandapat N, Roy S, Datta BK, Mandal TK, Basu D, Bhattacharya RN (2010b) Development of new localized drug delivery system based on ceftriaxone-sulbactam composite drug impregnated porous hydroxyapatite: a systematic approach for in vitro and in vivo animal trial. Pharm Res 27:1659–1676.

Noble L, Gray AI, Sadiq L, Uchegbu IF (1999) A non-covalently cross-linked chitosan based hydrogel. Int J Pharm 192:173–182

Rossi S, Marciello M, Sandri G, Bonferoni MC, Ferrari F, Caramella C (2008) Chitosan ascorbate: a chitosan salt with improved penetration enhancement properties. Pharm Dev Technol 13:513–521

Ubaidulla U, Khar RK, Ahmad FJ, Tripathi P (2009) Optimization of chitosan succinate and chitosan phthalate microspheres for oral delivery of insulin using response surface methodology. Pharm Dev Technol 14:96–105

Baldrick P (2010) The safety of chitosan as a pharmaceutical excipient. Regul Toxicol Pharmacol 56:290–299

Kong M, Chen XG, Liu CS, Liu CG, Meng XH, Yu le J (2008) Antibacterial mechanism of chitosan microspheres in a solid dispersing system against E. coli. Colloids Surf 65:197–202

Park Y, Kim MH, Park SC, Cheong H, Jang MK, Nah JW, Hahm KS (2008) Investigation of the anti fungal activity and mechanism of action of LMWS-chitosan. J Microbiol Biotechnol 18:1729–1734

Rosenqvist K, Airaksinen S, Fraser SJ, Gordon KC, Juppo AM (2013) Interaction of bioactive glass with clodronate. Int J Pharm 452:102–107

Cross KJ, Huq NL, Stanton DP, Sum M, Reynolds EC (2004) NMR studies of a novel calcium, phosphate and fluoride delivery vehicle-alpha(S1)-casein(59-79) by stabilized amorphous calcium fluoride phosphate nanocomplexes. Biomaterials 25(20):5061–5069

Borges BC, de Souza Borges J, de Araujo LS, Machado CT, DosSantos AJ, de Assuncao Pinheiro IV (2011) Update on nonsurgical, ultraconservative approaches to treat effectivelynon-cavitated caries lesions in permanent teeth. Eur J Dent 5(2):229–236

Fan Y, Sun Z, Moradian-Oldak J (2009) Controlled remineralizationof enamel in the presence of amelogenin and fluoride. Biomaterials 30(4):478–483

Nganga S, Zhang D, Moritz N, Vallittu PK, Hupa L (2012) Multi-layerporous fiber-reinforced composites for implants: in vitrocalcium phosphate formation in the presence of bioactiveglass. Dent Mater 28(11):1134–1145

Hench LL (1991) Bioceramics—from concept to clinic. J Am Ceram Soc 74(7):1487–1510

Bunker BC, Tallant DR, Headley TJ, Turner GL, Kirkpatrick RJ (1988) The structure of leached sodium borosilicate glass. Phys Chem Glasses 29(3):106–120

Hench LL, Splinter RJ, Allen WC, Greenlee TK (1972) Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res 2:117–141

Aitasalo K, Kinnunen I, Palmgren J, Varpula M (2001) Repair of orbital floor fractures with bioactive glass implants. J Oral Maxillofac Surg 59:1390–1396

Tesavibul P, Felzmann R, Gruber S, Liska R, Thompson I, Boccaccini AR et al (2012) Processing of 45S5 Bioglass—by lithography-based additive manufacturing. Mater Lett 74:81–84

Vitale-Brovarone C, Baino F, Verné E (2009) High strength bioactive glass-ceramic scaffolds for bone regeneration. J Mater Sci Mater Med 20:643–653

Izquierdo-Barba I, Salinas AJ, Vallet-Regí M (2013) Bioactive glasses: from macro tonano. Int J Appl Glass Sci 4:149–161

Merceron C, Vinatier C, Clouet J, Colliec-Jouault S, Weiss P, Guicheux J (2008) Adipose-derived mesenchymal stem cells and biomaterials for cartilage tissue engineering. Joint Bone Spine. Rev Rhum 75:672–674

Schneider OD, Weber F, Brunner TJ, Loher S, Ehrbar M, Schmidlin PR, Stark WJ (2009) Invivo and in vitro evaluation of flexible, cottonwool-like nano composites as bone substitute material for complex defects. Acta Biomater 5:1775–1784

Weiss P, Layrolle P, Clergeau LP, Enckel B, Pilet P, Amouriq Y, Daculsi G, Giumelli B (2007) The safety and efficacy of an injectable bone substitute in dental sockets demonstrated in a human clinical trial. Biomaterials 28:3295–3305

Williams DF (2008) On the mechanisms of biocompatibility. Biomaterials 29:2941–2953

Ducheyne P (2011) Biomaterials. In: Ducheyne P (ed), Comprehensive biomaterials, Elsevier, Oxford, pp 1–4

Hench LL, Day DE, Höland W, Rheinberger VM (2010) Glassand medicine. Int J Appl Glass Sci 1:104–117

Hoppe A, Guldal NS, Boccaccini AR (2011) A review of the biological response toionic dissolution products from bioactive glasses and glass–ceramics. Biomaterials 32:2757–2774

Xynos ID, Edgar AJ, Lee DK, Larry B, Hench L, Polak JM (2001) Gene-expression profiling of human osteoblasts following treatment with the ionic productsof Bioglass 45S5 dissolution. J Biomed Mater Res 55:151–157

Hench LL (1994) Bioactive ceramics: theory and clinical applications, Oxford

Agathopoulos S, Tulyaganov DU, Valerio P, Ferreira JM (200) A new model formulation of the SiO₂–Al2O₃–B2O₃–MgO–CaO–Na₂O–F glass–ceramics. Biomaterials 26:2255–2264

Kansal I, Tulyaganov DU, Goel A, Pascual MJ, Ferreira JMF(2010) Structural analysis and thermal behavior of diopside–fluorapatite–wollas-tonite-based glasses and glass–ceramics. Acta Biomater 6:4380–4388

Tulyaganov DU, Agathopoulos S, Ventura JM, Karakassides MA, Fabrichnaya O, Ferreira JMF (2006) Synthesis of glass–ceramics in the CaO–MgO–SiO₂ system with B₂O₃, P₂O₅, Na₂O and CaF₂ additives. J Eur Ceram Soc 26:1463–1471

Agathopoulos S, Tulyaganov DU, Ventura JMG, Kannan S, Saranti A, Karakassides MA, Ferreira JMF (2006) Structural analysis and devitrification of glasses based on the CaO–MgO–SiO₂ system with B₂O₃, Na₂O, CaF₂ and P2O5 additives. J Non Cryst Solids 352:322–328

Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials 27:3413–3431

Saboori A, Rabiee M, Mutarzadeh F, Sheikhi M, Tahriri M, Karimi M (2009) Synthesis, characterizations and in vitro bioactivity of sol–gel-derived SiO₂–CaO–P₂O₅–MgO bioglass. Mater Sci Eng C 29:335–340

Catauro M, Raucci MG, De Gaetano F, Marotta A (2004) Antibacterial and bioactive silver-containing Na₂O–CaO–2SiO₂ glass prepared by sol–gel method. J Mater Sci Mater Med 15:831–837

Ragel CV, Vallet-Regí M (2000) In vitro bioactivity and gentamicin release from glass–polymer-antibiotic composites. J Biomed Mater Res 51:424–429

Arcos D, Ragel CV, Vallet-Regi M (2001) Bioactivity in glass/PMMA composites used as drug delivery system. Biomaterials 22:701–708

Ladrón de Guevara S, Ragel CV, Vallet-Regí M (2003) Bioactive glass–polymer materials for controlled release of ibuprofen. Biomaterials 24:4037–4043

Arcos D, Peña J, Vallet-Regí M (2003) Influence of a SiO₂–CaO–P₂O₅ sol–gel on the bioactivity and controlled release of a ceramic/polymer/antibiotic mixed materials. Chem Mater 15:4132–4138

Arcos D, del Real RP, Vallet-Regí M (2002) A novel bioactive and magnetic biphasic material. Biomaterials 23:2151–2158

Ruiz E, Serrano MC, Arcos D, Vallet-Regí M (2006) Glass–glass ceramic thermoseeds for hyperthermic treatment of bone tumours. J Biomed Mater Res 79:533–543

Serrano MC, Portoles MT, Pagani R, Sáez de Guinoa J, Ruíz-Fernández E, Arcos D et al (2008) In vitro positive biocompatibility evaluation of glass–glass ceramic thermoseeds for hyperthermic treatment of bone tumours. Tissue Eng 14:617–627

Ragel CV, Vallet-Regí M, Rodríguez-Lorenzo LM (2002) Preparation and in vitro bioactivity of hydroxyapatite/solgel-glass biphasic material. Biomaterials 23:1865–1872

Vallet-Regí M, Rámila A, Padilla S, Muñoz B (2003) Bioactive glasses as accelerators of the apatites bioactivity. J Biomed Mater Res 66:580–585

Campostrini R, Carturam G (1996) Immobilisation of plant cells in hybrid sol–gel material. J Sol-Gel Sci Technol 7:87–97

Pope Edgard JA (1997) Bioartificial organs I: silica gel encapsulated pancreatic islets for the treatment of diabetes mellitus. J Sol-Gel Sci Technol 8:635–639

Vallet-Regí M (2006) Revisiting ceramics for medical applications. Dalton Trans 44:5211–5220

Vallet-Regí M, Balas F, Arcos D (2007) Mesoporous materials for drug delivery. Angew Chem Int Ed 46:7548–7558

López-Noriega A, Arcos D, Izquierdo-Barba I, Sakamoto Y, Terasaki O, Vallet- Regí M (2006) Ordered mesoporous bioactive glasses for bone tissue regeneration. Chem Mater 18:3137–3144

Izquierdo-Barba I, Arcos D, Sakamoto Y, Terasaki O, López-Noriega A, Vallet- Regí M (2008) High-performance mesoporous bioceramics mimicking bone mineralization. Chem Mater 20:3191–3198

Leonova E, Izquierdo-Barba I, Arcos D, López-Noriega A, Hedi N, Vallet-Regí M et al (2008) Multinuclear solid-state NMR studies of ordered mesoporous bioactive glasses. J Phys Chem C 112:5552–5562

Garcia A, Cicuendez M, Izquierdo-Barba I, Arcos D, Vallet-Regí M (2009) Essential role of calcium phosphate heterogeneities in 2D-hexagonal and 3D-cubic SiO₂–CaO–P₂O₅ mesoporous bioactive glasses. Chem Mater 21:5474–5484

Donlan RM, Costerton JW (2002) Clin Microbiol Rev 15:167

Hanssen AD (2005) Clin Orthop Relat Res P 437

Brown RF, Rahaman MN, Dwilewicz AB, Huang W, Day DE, Li Y, Bal BS (2009) J Biomed Mater Res A 88:392

Zhang D, Munukka E, Hupa L, Ylänen HO, Viljanen MK, Hupa M (2007) Key Eng Mater 173:330–332

Fu Q, Huang W, Jia W, Rahaman MN, Liu X, Tomsia AP (2011) Tissue Eng A 17:3077

Kaur G, Pandey OP, Singh K, Homa D, Scott B, Pickrell G (2013) A review of bioactive glasses: their structure, properties, fabrication, and apatite formation. J Biomed Mater Res A 102:254–274

Kaur G, Sharma P, Kumar V, Singh K (2012) Assesment of in-vitro bioactivity of SiO₂-BaO-ZnO-B₂O₃-Al₂O₃ glasses: an optico-analytical approach. Mater Sci Engg C 32(7):1941–1947

Kaur G, Pickrell G, Sriranganathan N, Kumar V, Homa D (2016) Review and the state of the art: Sol-gel or melt quenched bioactive glasses for tissue engineering. J Biomed Mater Res: B Appl Biomater 104(6):1248–1275. doi:10.1002/jbm.b.33443

Kaur G, Pickrell G, Pandey OP, Singh K, Chudasama BN, Kumar V (2016) Combined and individual Doxorubicin/Vancomycin drug loading, release kinetics and apatite formation for the CaO-CuO-P₂O₅- SiO₂- B₂O₃ mesoporous glasses. RSC Adv 6:51046–51056

Kaur G, Pickrell G, Kimsawatde G, Allbee H, Sriranganathan N (2014) Synthesis, cytotoxicity, and hydroxypatite formation in 27-Tris-SBF for sol-gel based CaO-P₂O₅-SiO₂-B₂O₃-ZnO bioactive glasses. Sci Rep. doi:10.1038/srep04392

Title: Future Perspectives of Bioactive Glasses for the Clinical Applications
Authors: V. Kumar
G. Pickrell
S.G. Waldrop
N. Sriranganathan
Publisher: Springer International Publishing
Book: Bioactive Glasses
Print ISBN: 978-3-319-45715-4

Electronic ISBN: 978-3-319-45716-1

Copyright Year: 2017
DOI: https://doi.org/10.1007/978-3-319-45716-1_11