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Published in:
2007 | OriginalPaper | Chapter
Generating Fiber Crossing Phantoms Out of Experimental DWIs
Authors : Matthan Caan, Anne Willem de Vries, Ganesh Khedoe, Erik Akkerman, Lucas van Vliet, Kees Grimbergen, Frans Vos
Published in: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2007
Publisher: Springer Berlin Heidelberg
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In Diffusion Tensor Imaging (DTI), differently oriented fiber bundles inside one voxel are incorrectly modeled by a single tensor. High Angular Resolution Diffusion Imaging (HARDI) aims at using more complex models, such as a two-tensor model, for estimating two fiber bundles.
We propose a new method for creating experimental phantom data of fiber crossings, by mixing the DWI-signals from high FA-regions with different orientation. The properties of these experimental phantoms approach the conditions of real data. These phantoms can thus serve as a ‘ground truth’ in validating crossing reconstruction algorithms. The angular resolution of a dual tensor model is determined using series of crossings, generated under different angles. An angular resolution of 0.6
π
was found in data scanned with a diffusion weighting parameter
b
=1000 s/mm
2
. This resolution did not change significantly in experiments with
b
=3000 and 5000 s/mm
2
, keeping the scanning time constant.