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Published in:
2009 | OriginalPaper | Chapter
Hansenula polymorpha (Pichia angusta): Biology and Applications
Authors : Gotthard Kunze, Hyun Ah Kang, Gerd Gellissen
Published in: Yeast Biotechnology: Diversity and Applications
Publisher: Springer Netherlands
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Hansenula polymorpha (Pichia angusta)
belongs to a limited number of methylotrophic yeast species. It is able to assimilate nitrate and can grow on a range of carbon sources. Furthermore,
H. polymorpha
is a thermo-tolerant microorganism with some strains growing at temperatures up to 50° C and more. These unusual characteristics render
H. polymorpha
attractive as a model organism to study the development and functions of peroxisomes and the biochemistry of nitrate assimilation.
H. polymorpha
provides an established platform for heterologous gene expression and is distinguished by an impressive track record as producer of recom-binant proteins that include commercially available pharmaceuticals like hepatitis B vaccine, insulin and the IFN α-2a