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Published in:
2013 | OriginalPaper | Chapter
HaptreeBuilder: Web Generation and Visualization of Risk Haplotype Trees
Authors : Dimitra Kamari, María Mar Abad-Grau, Fuencisla Matesanz
Published in: 7th International Conference on Practical Applications of Computational Biology & Bioinformatics
Publisher: Springer International Publishing
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The quantity and quality of genome-wide association studies for several diseases are constantly increasing. As a consequence, molecular biologists from different laboratories demand new visualization tools for them to explore results by view and formulate new conjectures to work on. Although nowadays most studies are not able to reconstruct individual haplotypes, the next generation sequencying technologies will allow to obtain individual haplotypes in most studies conducted in the next few years. As evolutionary analysis of the haplotypes can be an invaluable information to biomedical researchers to build hypotheses of genetic variation by considering haplotype evolution, we have build a web-based tool for biomedical researchers to build and visualize risk haplotype trees along a chromosome so that they can perform a visual online exploration of the genetic factors associated with complex diseases.