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Biomaterial Surfaces for the Isolation of Hematopoietic Stem and Progenitor Cells Read chapter Read first chapter

2012 | OriginalPaper | Chapter

6. Host Response to Biomaterials

Authors : Anjelica L. Gonzalez-Simon, Omolola Eniola-Adefeso

Published in: Engineering Biomaterials for Regenerative Medicine

Publisher: Springer New York

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Abstract

The implantation of a biomaterial-based device or drug carrier will elicit a localized or systemic inflammatory response. An immune response occurs regardless of the method of introduction of biomaterial into the body, as all methods of biomaterial insertion, including surgery and injection, result in the disruption of the host’s tissue. The extent of the inflammatory response, however, is dependent upon the location, implantation procedure, and compatibility of biomaterial. In general, inflammatory responses can be classified as acute or chronic, defined primarily by the duration of the response and the type of cells infiltrating a tissue in response to pro-inflammatory signals. This chapter discusses the general process of acute and chronic inflammatory response and gives details on the key immune cells and soluble blood plasma factors involved. Information is also provided on biomaterial design approaches employed to minimizing inflammatory response.

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Metadata
Title
Host Response to Biomaterials
Authors
Anjelica L. Gonzalez-Simon
Omolola Eniola-Adefeso
Copyright Year
2012
Publisher
Springer New York
Book
Engineering Biomaterials for Regenerative Medicine

Print ISBN: 978-1-4614-1079-9

Electronic ISBN: 978-1-4614-1080-5

Copyright Year: 2012

DOI
https://doi.org/10.1007/978-1-4614-1080-5_6

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