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Three-Dimensional Quantification of Myocardial Collagen Morphology from Confocal Images Read chapter Read first chapter

2017 | OriginalPaper | Chapter

Image-Based Modeling of the Heterogeneity of Propagation of the Cardiac Action Potential. Example of Rat Heart High Resolution MRI

Authors : Anđela Davidović, Yves Coudière, Yves Bourgault

Published in: Functional Imaging and Modelling of the Heart

Publisher: Springer International Publishing

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Abstract

In this paper we present a modified bidomain model, derived with homogenization technique from assumption of existence of diffusive inclusions in the cardiac tissue. The diffusive inclusions represent regions without electrically active myocytes, e.g. fat, fibrosis etc. We present the application of this model to a rat heart. Starting from high resolution (HR) MRI, geometry is built and meshed using image processing techniques. We perform a study on the effects of tissue heterogeneities induced with diffusive inclusions on the velocity and shape of the depolarization wavefront. We study several test cases with different geometries for diffusive inclusions, and we find that the velocity might be affected by \(5\%\) and up to \(37\%\) in some cases. Additionally, the shape of the wavefront is affected.

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previous chapter Variance Based Sensitivity Analysis of in a Model of the Human Atrial Action Potential Using Gaussian Process Emulators
next chapter VT Scan: Towards an Efficient Pipeline from Computed Tomography Images to Ventricular Tachycardia Ablation
Footnotes
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Metadata
Title
Image-Based Modeling of the Heterogeneity of Propagation of the Cardiac Action Potential. Example of Rat Heart High Resolution MRI
Authors
Anđela Davidović
Yves Coudière
Yves Bourgault
Copyright Year
2017
Book
Functional Imaging and Modelling of the Heart

Print ISBN: 978-3-319-59447-7

Electronic ISBN: 978-3-319-59448-4

Copyright Year: 2017

DOI
https://doi.org/10.1007/978-3-319-59448-4_25

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