2015 | OriginalPaper | Chapter
Immunoglobulin Classification Using the Colored Antibody Graph
Authors : Stefano R. Bonissone, Pavel A. Pevzner
Published in: Research in Computational Molecular Biology
Publisher: Springer International Publishing
Activate our intelligent search to find suitable subject content or patents.
Select sections of text to find matching patents with Artificial Intelligence. powered by
Select sections of text to find additional relevant content using AI-assisted search. powered by
The somatic recombination of V, D, and J gene-segments in B-cells, introduces a great deal of diversity, and divergence from reference segments. Many recent studies of antibodies focus on the population of antibody transcripts that show which V, D, and J gene-segments have been favored for a particular antigen, a repertoire. To properly describe the antibody repertoire, each antibody must be labeled by its constituting V, D, and J gene-segment, a task made difficult by somatic recombination and hypermutation events. While previous approaches to repertoire analysis were based on sequential alignments, we describe a new de Bruijn graph based algorithm to perform VDJ labeling, and benchmark its performance.