Impact of Dietary Fibers on the Biochemical Markers of Bone Remodeling in Hemodialyzed Postmenopausal Women (Algeria)

According to WHO, osteoporosis is the second most important public health problem after cardiovascular disease. About 200 million women in the world have osteoporosis; it is the second leading cause of death in women after breast cancer. In Algeria, 4 million people suffer from osteoarthritic diseases and 40% of those are women. The ultimate objective of our study was to evaluate the impact of dietary fiber from carrots and wheat bran on biochemical markers of bone remodeling in postmenopausal hemodialysis women. The study population consisted of 30 postmenopausal women (61.39 ± 8.44 years) receiving hemodialysis treatment as well as diets high in dietary fiber to assess the state of their bones. Biochemical markers of osteoresorption: pyridinoline LP and hydroxypyridinoline HP in urine were measured by the HPLC method, as well as the biochemical markers of osteoformation: total alkaline phosphatase (ALP) and calcium balance. This population was divided into four groups, T-controls who followed a regular diet, GC group: a high-carrot diet, GS group: hard wheat bran (100 g/day), and the GCS group: a mixture of these two foods (50/50 g/day). And the three groups GC, GS, and GCS receive a calcium intake (800 g/day) of calcium carbonate orally for 1 month. Urine and blood samples were taken weekly: T0, T7, T15, T21, T30, and T45. Our results show that women under carrot diet excreted significantly (p < 0.05) the highest values of hydroxypyridinolines (HP) and pyridinolines (LP), in their different forms, as well as calciuria and PAL. While the wheat diet shows lower levels of HP and no effect on other markers of osteoresorption and osteoformation.