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Published in:
2012 | OriginalPaper | Chapter
In Silico Infection of the Human Genome
Authors : W. B. Langdon, M. J. Arno
Published in: Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics
Publisher: Springer Berlin Heidelberg
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The human genetic sequence database contains DNA sequences very like those of mycoplasma bacteria. It appears such bacteria infect not only molecular Biology laboratories but their genes were picked up from contaminated samples and inserted into GenBank as if they were homo sapiens. At least one mouldy EST (Expressed Sequence Tag) has transferred from online public databases on the Internet to commercial tools (Affymetrix HG-U133 plus 2.0 microarrays). We report a second example (DA466599) and suggest there is a need to clean up genomic databases but fear current tools will be inadequate to catch genes which have jumped the silicon barrier.