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Published in:
2011 | OriginalPaper | Chapter
Integration of the Calcium Dynamics in the Excitation Contraction Coupling Process within a Multiscale Model of the Left Ventricle
Authors : B. Bhattacharya-Ghosh, S. Schievano, V. Díaz-Zuccarini
Published in: International Conference on Advancements of Medicine and Health Care through Technology
Publisher: Springer Berlin Heidelberg
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The description of multiscale processes in a unified and coherent fashion is of paramount importance in cardiovascular computational physiology. In this paper, a model that links the process of cardiac excitation and contraction from a cellular to a tissue level will be presented. A model of the action potential will be linked to the kinetics (attachment and detachment) of the proteins responsible for cardiac contraction (via the so called “crossbridges mechanism”). As a final step, the coupling of the calcium-dependent kinetics model to a higher-scale model of the left ventricle will complete the multi-scale model of cardiac dynamics from the sub-cellular level to the organ.