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2008 | OriginalPaper | Chapter
Macromolecular Transport in Arterial Walls: Current and Future Directions
Authors : K. Khanafer, K. Vafai
Published in: Emerging Topics in Heat and Mass Transfer in Porous Media
Publisher: Springer Netherlands
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Relevant mathematical models associated with the transport of macromolecules in the blood stream and in the arterial walls are reviewed in this work. A robust four-layer model (endothelium, intima, internal elastic lamina and media) based on porous media concept and accounting for selective permeability of each porous layer to certain solutes is presented to describe the transport of macromolecules in the arterial wall coupled with the transport in the lumen. The variances in the current models are analyzed and discussed. Future direction in developing a rigorous mathematical model for transport in arterial walls using porous media theory and fluid-structure interaction approach is outlined in this study.