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Journal of Materials Science
Published in: Journal of Materials Science 10/2018

13-02-2018 | Biomaterials

Mesoporous silica-coated gold nanorods with a thermally responsive polymeric cap for near-infrared-activated drug delivery

Authors: Zhixuan Song, Jun Shi, Zheng Zhang, Zeer Qi, Shangru Han, Shaokui Cao

Published in: Journal of Materials Science | Issue 10/2018

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Abstract

In this work, gold nanorods (AuNRs)/mesoporous silica (SiO2) nanoparticles capped with thermal-responsive polymer were fabricated to couple the photothermal property of AuNRs and the thermal-/pH-responsive properties of polymer in a single nanovehicle. Aliphatic poly(urethane-amine) (PUA) was employed as the smart polymer to cap the mesopores of AuNRs/SiO2 nanoparticles via in situ polymerization in supercritical CO2. Thermal-/pH-responsive PUA acted as the on–off switch to control the DOX release due to the stretch and shrinkage of the PUA polymer chains at different temperatures, whereas a remote near-infrared (NIR) light was used to activate the phase change and subsequent drug release. The in vitro drug release studies indicated that Au/SiO2/PUA nanoparticles exhibited distinguished pH-, thermal-, and NIR-dependent release properties. A short time exposure to NIR irradiation could distinctly increase the local temperature of nanoparticles, and the thermal-responsive polymeric cap enabled the DOX release in a significant reversible way by simply adjusting the NIR laser intensity. The present paper provides an ideal way to fabricate NIR-responsive drug carriers by combining stimuli-responsive polymer with inorganic matrix, which is highly attractive for remote controllable drug delivery.
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Appendix
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Literature
1.
Liu J, Detrembleur C, De Pauw-Gillet MC, Mornet S, Jerome C, Duguet E (2015) Gold nanorods coated with mesoporous silica shell as drug delivery system for remote near infrared light-activated release and potential phototherapy. Small 11:2323–2332CrossRef
2.
Mura S, Nicolas J, Couvreur P (2013) Stimuli-responsive nanocarriers for drug delivery. Nat Mater 12:991–1003CrossRef
3.
Brigger I, Dubernet C, Couvreur P (2012) Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 64:24–36CrossRef
4.
5.
Chen Y, Zhang ZH, Han X, Yin J, Wu ZQ (2016) Oxidation and acid milieu-disintegratable nanovectors with rapid cell-penetrating helical polymer chains for programmed drug release and synergistic chemo-photothermal therapy. Macromolecules 49:7718–7727CrossRef
6.
Rai P, Mallidi S, Zheng X, Rahmanzadeh R, Mir Y, Elrington S, Khurshid A, Hasan T (2010) Development and applications of photo-triggered theranostic agents. Adv Drug Deliv Rev 62:1094–1124CrossRef
7.
Xie J, Lee S, Chen X (2010) Nanoparticle-based theranostic agents. Adv Drug Deliv Rev 62:1064–1079CrossRef
8.
Fang L, Wang W, Liu Y, Xie Z, Chen L (2017) Janus nanostructures formed by mesoporous silica coating Au nanorods for near-infrared chemo–photothermal therapy. J Mater Chem B 5:8833–8838CrossRef
9.
Shen S, Tang H, Zhang X, Ren J, Pang Z, Wang D, Gao H, Qian Y, Jiang X, Yang W (2013) Targeting mesoporous silica-encapsulated gold nanorods for chemo-photothermal therapy with near-infrared radiation. Biomaterials 34:3150–3158CrossRef
10.
Zhang Z, Wang L, Wang J, Jiang X, Li X, Hu Z, Ji Y, Wu X, Chen C (2012) Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Adv Mater 24:1418–1423CrossRef
11.
Tang F, Li L, Chen D (2012) Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery. Adv Mater 24:1504–1534CrossRef
12.
Wang Y, Shi W, Wang S, Li C, Qian M, Chen J, Huang R (2016) Facile incorporation of dispersed fluorescent carbon nanodots into mesoporous silica nanosphere for pH-triggered drug delivery and imaging. Carbon 108:146–153CrossRef
13.
Chu Z, Yin C, Zhang S, Lin G, Li Q (2013) Surface plasmon enhanced drug efficacy using core-shell Au@SiO2 nanoparticle carrier. Nanoscale 5:3406–3411CrossRef
14.
Coll C, Bernardos A, Martãnezmã ÃER, SancenãN F (2013) Gated silica mesoporous supports for controlled release and signaling applications. Acc Chem Res 46:339–349CrossRef
15.
Baek S, Singh RK, Kim TH, Seo JW, Shin US, Chrzanowski W, Kim HW (2016) Triple hit with drug carriers: pH- and temperature- responsive theranostics for multimodal chemo- and photothermal therapy and diagnostic applications. ACS Appl Mater Interfaces 8:8967–8979CrossRef
16.
Chen X, Soeriyadi AH, Lu X, Sagnella SM, Kavallaris M, Gooding JJ (2014) Dual bioresponsive mesoporous silica nanocarrier as an “AND” logic gate for targeted drug delivery cancer cells. Adv Funct Mater 24:6999–7006CrossRef
17.
Tarn D, Ashley CE, Xue M, Carnes EC, Zink JI, Brinker CJ (2013) Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility. Acc Chem Res 46:792–801CrossRef
18.
Zhu CL, Lu CH, Song XY, Yang HH, Wang XR (2011) Bioresponsive controlled release using mesoporous silica nanoparticles capped with aptamer-based molecular gate. J Am Chem Soc 133:1278–1281CrossRef
19.
Yang X, Liu X, Liu Z, Pu F, Ren J, Qu X (2012) Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles. Adv Mater 24:2890–2895CrossRef
20.
Singh N, Karambelkar A, Gu L, Lin K, Miller JS, Chen CS, Sailor MJ, Bhatia SN (2011) Bioresponsive mesoporous silica nanoparticles for triggered drug release. J Am Chem Soc 133:19582–19585CrossRef
21.
Sobot D, Mura S, Yesylevskyy SO, Dalbin L, Cayre F, Bort G, Mougin J, Desmaële D, Lepetremouelhi S, Pieters G (2017) Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery. Nat Comm 8:1–9CrossRef
22.
Zhang Z, Wang J, Nie X, Wen T, Ji Y, Wu X, Zhao Y, Chen C (2014) Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods. J Am Chem Soc 136:7317–7326CrossRef
23.
Xu X, Bai B, Wang H, Suo Y (2017) A near-infrared and temperature-responsive pesticide release platform through core-shell polydopamine@PNIPAm nanocomposites. ACS Appl Mater Interfaces 9:6424–6432CrossRef
24.
Pester CW, Konradi A, Varnholt B, Van Rijn P, Böker A (2012) Microstructures: responsive macroscopic materials from self-assembled cross-linked SiO2- PNIPAAm core/shell structures. Adv Funct Mater 22:1723CrossRef
25.
Wu Q, Shi J, Wei J, Yang L, Cao S (2015) In situ functionalization of hollow mesoporous hydroxyapatite with thermal-responsive on-off gates in supercritical CO2. RSC Adv 5:70101–70108CrossRef
26.
Zdrahala RJ, Zdrahala IJ (1999) Biomedical applications of polyurethanes: a review of past promises, present realities, and a vibrant future. J Biomater Appl 14:67–90CrossRef
27.
Alkilany AM, Thompson LB, Boulos SP, Sisco PN, Murphy CJ (2012) Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. Adv Drug Deliv Rev 64:190–199CrossRef
28.
An X, Zhan F, Zhu Y (2013) Smart photothermal-triggered bilayer phase transition in AuNPs-liposomes to release drug. Langmuir 29:1061–1068CrossRef
29.
Boisselier E, Astruc D (2009) Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem Soc Rev 38:1759–1782CrossRef
30.
He Q, Shi J (2011) Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility. J Mater Chem 21:5845–5855CrossRef
31.
Lee CH, Cheng SH, Wang YJ, Chen YC, Chen NT, Souris J, Chen CT, Mou CY, Yang CS, Lo LW (2009) Near-infrared mesoporous silica nanoparticles for optical imaging: characterization and in vivo biodistribution. Adv Funct Mater 19:215–222CrossRef
32.
And BN, Elsayed MA (2003) Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method. Chem Mater 15:1957–1962CrossRef
33.
Gorelikov I, Matsuura N (2008) Single-step coating of mesoporous silica on cetyltrimethyl ammonium bromide-capped nanoparticles. Nano Lett 8:369–373CrossRef
34.
Wei J, Shi J, Wu Q, Yang L, Cao S (2015) Hollow hydroxyapatitepolyelectrolyte hybrid microparticles with controllable size, wall thickness and drug delivery properties. J Mater Chem B 3:8162–8169CrossRef
35.
Pezaranguren PL, Vega LF, Domingo C (2013) A new method using compressed CO2 for the in situ functionalization of mesoporous silica with hyperbranched polymers. Chem Commun 49:11776–11779CrossRef
36.
Ihata O, Kayaki Y, Ikariya T (2004) Synthesis of thermoresponsive polyurethane from 2-methylaziridine and supercritical carbon dioxide. Angew Chem 43:717–719CrossRef
37.
And OI, Kayaki Y, Ikariya T (2005) Aliphatic poly(urethane–amine)s synthesized by copolymerization of aziridines and supercritical carbon dioxide. Macromolecules 38:6429–6434CrossRef
38.
Xu S, Shi J, Feng D, Yang L, Cao S (2014) Hollow hierarchical hydroxyapatite/Au/polyelectrolyte hybrid microparticles for multi-responsive drug delivery. J Mater Chem B 2:6500–6507CrossRef
39.
40.
Sun Q, You Q, Pang X, Tan X, Wang J, Liu L, Guo F, Tan F, Li N (2017) A photoresponsive and rod-shape nanocarrier: single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped & Ce6-doped mesoporous silica nanorods. Biomaterials 122:188–200CrossRef
41.
Liu J, Detrembleur C, Hurtgen M, Debuigne A, Pauwgillet MCD, Mornet S, Duguet E, Jérôme C (2013) Reversibly crosslinked thermo- and redox-responsive nanogels for controlled drug release. Polym Chem 5:77–88CrossRef
42.
Liu J, Detrembleur C, Debuigne A, Pauw-Gillet MCD, Mornet S, Elst LV, Laurent S, Duguet E, Jérôme C (2014) Glucose-, pH- and thermo-responsive nanogels crosslinked by functional superparamagnetic maghemite nanoparticles as innovative drug delivery systems. J Mater Chem B 2:1009–1023CrossRef
43.
Du C, Shi J, Shi J, Zhang L, Cao S (2013) PUA/PSS multilayer coated CaCO3 microparticles as smart drug delivery vehicles. Mater Sci Eng C 33:3745–3752CrossRef
44.
Shi J, Wang X, Xu S, Wu Q, Cao S (2016) Reversible thermal-tunable drug delivery across nano-membranes of hollow PUA/PSS multilayer microcapsules. J Membr Sci 499:307–316CrossRef
45.
Song Z, Liu Y, Shi J, Ma T, Zhang Z, Ma H, Cao S (2018) Hydroxyapatite/mesoporous silica coated gold nanorods with improved degradability as a multi-responsive drug delivery platform. Mater Sci Eng C 83:90–98CrossRef
46.
Guo YJ, Wang YY, Chen T, Wei YT, Chu LF, Guo YP (2013) Hollow carbonated hydroxyapatite microspheres with mesoporous structure: hydrothermal fabrication and drug delivery property. Mater Sci Eng C 33:3166–3172CrossRef
47.
Wang P, Chen S, Cao Z, Wang G (2017) NIR light-, temperature-, ph-, and redox-responsive polymer-modified reduced graphene oxide/mesoporous silica sandwich-like nanocomposites for controlled release. ACS Appl Mater Interfaces 9:29055–29062CrossRef
48.
Metadata
Title
Mesoporous silica-coated gold nanorods with a thermally responsive polymeric cap for near-infrared-activated drug delivery
Authors
Zhixuan Song
Jun Shi
Zheng Zhang
Zeer Qi
Shangru Han
Shaokui Cao
Publication date
13-02-2018
Publisher
Springer US
Published in
Journal of Materials Science / Issue 10/2018
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-2117-7

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