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2021 | OriginalPaper | Chapter

Mitochondria Dysfunction on Striatum After a Chronic Exposure to Pesticides Mixture in Rats

Authors : Salim Gasmi, Brahim Ben Aicha, Rachid Rouabhi, Samira Boussekine, Mohamed Kebieche

Published in: Recent Advances in Environmental Science from the Euro-Mediterranean and Surrounding Regions (2nd Edition)

Publisher: Springer International Publishing

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Abstract

Cypermethrin (CYP) and Acetamiprid (AC) are two pesticides widely used in Algeria to eliminate insects that spoil crops and transport disease. In this study, the neurobehavioral effects induced by a mixture of the pesticides (CYP+AC) were tested at doses of 3.14 and 0.32 mg/kg for three months. The evaluation of mitochondrial oxidative stress on striatum tissues was recorded. According to the main results, CYP+AC mixture led to the disruption of mitochondrial parameters evaluated by a significant increase of MDAmit level, of GSTmit and SODmit activities, and a significant decrease of GSHmit level, CATmit and GPxmit activities. Due to disruption of some of mitochondria antioxidant enzymes, which may be the main cause of brain cell degeneration and decrease of learning and memorizing rate, the administration of CYP+AC mixture induced neurotoxicity.

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Title: Mitochondria Dysfunction on Striatum After a Chronic Exposure to Pesticides Mixture in Rats
Authors: Salim Gasmi
Brahim Ben Aicha
Rachid Rouabhi
Samira Boussekine
Mohamed Kebieche
Publisher: Springer International Publishing
Book: Recent Advances in Environmental Science from the Euro-Mediterranean and Surrounding Regions (2nd Edition)
Print ISBN: 978-3-030-51209-5

Electronic ISBN: 978-3-030-51210-1

Copyright Year: 2021
DOI: https://doi.org/10.1007/978-3-030-51210-1_98