Advertisement
Published in:
2018 | OriginalPaper | Chapter
8. Morning and Evening Peaking Rhythmic Genes are Regulated by Distinct Transcription Factors in Neurospora crassa
Authors : Robert Lehmann, Hanspeter Herzel, Michael Brunner, Gencer Sancar, Cigdem Sancar, Bharath Ananthasubramaniam
Published in: Information- and Communication Theory in Molecular Biology
Publisher: Springer International Publishing
Activate our intelligent search to find suitable subject content or patents.
Select sections of text to find matching patents with Artificial Intelligence. powered by
Select sections of text to find additional relevant content using AI-assisted search. powered by
Abstract
Eukaryotic genes are typically regulated by multiple transcription factors in a combinatorial manner. Quantitative understanding of gene regulation is particularly relevant for oscillatory expression due to transcriptional feedback loops. For periodic gene expression, the phases are essential for physiological functions.In our project we combine bioinformatic promoter analysis, large scale experiments (expression profiles and ChIP-Seq), and kinetic modeling to explore the information transfer from activators and repressors to gene expression phases. A comparative analysis of mammalian and fungal circadian rhythms allows to elucidate general design principles of phase regulation: Enhanced amplitudes via OR funnels and generation of harmonics via AND funnels.