2015 | OriginalPaper | Chapter
MRI-Based Lesion Profiling of Epileptogenic Cortical Malformations
Authors : Seok-Jun Hong, Boris C. Bernhardt, Dewi Schrader, Benoit Caldairou, Neda Bernasconi, Andrea Bernasconi
Published in: Medical Image Computing and Computer-Assisted Intervention -- MICCAI 2015
Publisher: Springer International Publishing
Activate our intelligent search to find suitable subject content or patents.
Select sections of text to find matching patents with Artificial Intelligence. powered by
Select sections of text to find additional relevant content using AI-assisted search. powered by
Focal cortical dysplasia (FCD), a malformation of cortical development, is a frequent cause of drug-resistant epilepsy. This lesion is histologically classified into Type-IIA (dyslamination, dysmorphic neurons) and Type-IIB (dyslamination, dysmorphic neurons, and balloon cells). Reliable
in-vivo
identification of lesional subtypes is important for preoperative decision-making and surgical prognostics. We propose a novel multi-modal MRI lesion profiling based on multiple surfaces that systematically sample intra- and subcortical tissue. We applied this framework to histologically-verified FCD. We aggregated features describing morphology, intensity, microstructure, and function from T1-weighted, FLAIR, diffusion, and resting-state functional MRI. We observed alterations across multiple features in FCD Type-IIB, while anomalies in IIA were subtle and mainly restricted to FLAIR intensity and regional functional homogeneity. Anomalies in Type-IIB were seen across all intra- and sub-cortical levels, whereas those in Type-IIA clustered at the cortico-subcortical interface. A supervised classifier predicted the FCD subtype with 91% accuracy, validating our profiling framework at the individual level.