Skip to main content
Disciplines
Automotive Business IT + Informatics Construction + Real Estate Electrical Engineering + Electronics Energy + Sustainability Insurance + Risk Finance + Banking Management + Leadership Marketing + Sales Mechanical Engineering + Materials
Events
DE
EN
Books
Journals
Topic Page
Marketing
Start single access now
Access for companies
EXTENDED SEARCH
Log in
Top
Published in:
Promising Biomarkers: MicroRNAs at Diagnosis, Therapy and Prognostic Evaluation of Breast Cancer Read chapter Read first chapter

2014 | OriginalPaper | Chapter

124. Mutagenic Research on Ciliary Neurotrophic Factor (CNTF) in Escherichia coli After Heavy Ions Irradiation

Authors : Xiaodong Jin, Qingfeng Wu, Xinguo Liu, Yan Liu, Yong Chen, Jian Lu, Lin Jiang

Published in: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Publisher: Springer Berlin Heidelberg

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Based on the natural human CNTF gene, Ying et al. acquired CNTF-T mutant and constructed Escherichia coli expressing CNTF. In order to increase the yield and enhance the protein expression in the constructed E. coli, the strains were irradiated with high-LET heavy ions. Some mutants were obtained in this work and the mechanisms underlying the enhanced expression of CNTF in E. coli after exposure to heavy ions are discussed in this paper.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

inform now
previous chapter Research on Salt-tolerant Gene GPD1 in Zygosaccharomyces rouxii
next chapter Molecular Characterization and Expression of Ribosomal Protein L15 Gene (RPL15) From Arachis hypogaea
Literature
1.
Hamada N, Imaok T, Masunaga S et al (2010) Recent advances in the biology of heavy-ion cancer therapy. J Radiat Res 51:365–383CrossRef
2.
Matuo Y, Nishijima S, Hase Y et al (2006) Specificity of mutations induced by carbon ions in budding yeast Saccharomyces cerevisiae. Mutat Res 602:7–13CrossRef
3.
Kiefer J, Stoll U, Schneider E (1994) Mutation induction by heavy ions. Adv Space Res 14:257–265CrossRef
4.
Horneck G, Krasavin EA, Kozubek S (1994) Mutagenic effects of heavy ions in bacteria. Adv Space Res 14:315–329CrossRef
5.
Hamada N, Hara T, Funayama T et al (2008) Energetic heavy ions accelerate differentiation in the descendants of irradiated normal human diploid fibroblasts. Mutat Res 637:190–196CrossRef
6.
Kruttgen A, Grotzinger J, Kurapkat G et al (1995) Human ciliary neurotrophic factor: a structure-function analysis. Biochem J 309:215–220
7.
Gloaguen I, Coste P, Demartis A et al (1997) Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc Natl Acad Sci USA 94:6456–6461CrossRef
8.
Lambert P, Anderson K, Sleeman M et al (2001) Ciliary neurotrophic factor activates leptin-like pathways and reduces body weight gain, even in leptin-resistance obesity. Proc Natl Acad Sci USA 98:4652–4657CrossRef
9.
Ying LF, Lei Q, Liang LY et al (2007) Expression and biologic activity analysis of recombinant human ciliary neurotrophic factor (CNTF) mutant. Biotechology 17:16–18
Metadata
Title
Mutagenic Research on Ciliary Neurotrophic Factor (CNTF) in Escherichia coli After Heavy Ions Irradiation
Authors
Xiaodong Jin
Qingfeng Wu
Xinguo Liu
Yan Liu
Yong Chen
Jian Lu
Lin Jiang
Copyright Year
2014
Publisher
Springer Berlin Heidelberg
Book
Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Print ISBN: 978-3-642-37921-5

Electronic ISBN: 978-3-642-37922-2

Copyright Year: 2014

DOI
https://doi.org/10.1007/978-3-642-37922-2_124

Premium Partners

    Image Credits