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2022 | OriginalPaper | Chapter

Nano- and Microparticles and Their Role in Inflammation and Immune Response: Focus on Neutrophil Extracellular Traps

Authors : Galyna Bila, Andrii Rabets, Rostyslav Bilyy

Published in: Biomedical Nanomaterials

Publisher: Springer International Publishing

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Abstract

Nano- and microparticles have become a normal part of our life, starting from medical drugs and cosmetics and ending in the television screens. Many of the nanoparticles are quite dangerous since the materials they use are not easily compatible with human tissue and provoke inflammation and immune responses. However, our body has developed the response on how to cope with those nanoparticles which are causing damaging effects to cells and tissues. This response is mediated by the neutrophilic granulocytes producing neutrophil extracellular traps—a weapon used to isolate and sequester particular matter in the safe deposits in the body. This chapter focuses on the mechanisms of how nanoparticles interact with neutrophils. It will provide an example of such interaction for main groups of nanoparticles—naturally occurring in the body, those formed during pathological conditions, and artificial pollutants. Examples of beneficial use of nanoparticle-induced inflammation are described for novel nanoadjuvants.

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Metadata
Title
Nano- and Microparticles and Their Role in Inflammation and Immune Response: Focus on Neutrophil Extracellular Traps
Authors
Galyna Bila
Andrii Rabets
Rostyslav Bilyy
Copyright Year
2022
DOI
https://doi.org/10.1007/978-3-030-76235-3_6