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2016 | OriginalPaper | Chapter

23. Nanomedicine

Authors : Eda Tahir Turanlı, Elif Everest

Published in: Low-Dimensional and Nanostructured Materials and Devices

Publisher: Springer International Publishing

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Abstract

Nanomedicine is application of nanotechnology to diagnosis, treatment and prevention of diseases, in which multidisciplinary approaches are used combining chemistry, physics, biology, genetics, and medicine. Currently, there are a number of approved nanomedicines some of which have been developed to treat diseases using two main different approaches; passive or active targeting. Others include in vitro and in vivo diagnostic nanoparticles that have been shown to have many advantages compared to the traditional methods. Although there are some safety issues regarding development and use of nanoparticles in medicine and controversies surrounding the need for nanomedicine-specific regulations; many nanomedicines have been approved to date, and further improvements are being pursued with promising success. In this chapter, we summarise the use, advantages, current and future statuses of pharmaceutical and diagnostic nanomedicines, including ethical issues and regulations.

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Literature
2.
go back to reference V. Wagner, B. Hüsing, S. Gaisser, Nanomedicine: Drivers for development and possible impacts. European Commission’s (EC) Joint Research Centre (JRC) Report No. 46744, 1–116 (2008) V. Wagner, B. Hüsing, S. Gaisser, Nanomedicine: Drivers for development and possible impacts. European Commission’s (EC) Joint Research Centre (JRC) Report No. 46744, 1–116 (2008)
3.
go back to reference G. Gregoriadis, B.E. Ryman, Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases. Biochem. J. 124, 58P (1971) G. Gregoriadis, B.E. Ryman, Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases. Biochem. J. 124, 58P (1971)
4.
go back to reference P.D. Brown, P.R. Patel, Nanomedicine: a pharma perspective. Wiley Interdiscip Rev Nanomed Nanobiotechnol 7, 125–130 (2015) P.D. Brown, P.R. Patel, Nanomedicine: a pharma perspective. Wiley Interdiscip Rev Nanomed Nanobiotechnol 7, 125–130 (2015)
5.
10.
go back to reference F.S. Collins, We need better drugs—now. TEDMed Conference (Long Beach, CA, USA, 2012) F.S. Collins, We need better drugs—now. TEDMed Conference (Long Beach, CA, USA, 2012)
11.
go back to reference T. Bartfai, G.V. Lees, The Future of Drug Discovery: Who Decides which Diseases to Treat? (Academic Press, 2013) T. Bartfai, G.V. Lees, The Future of Drug Discovery: Who Decides which Diseases to Treat? (Academic Press, 2013)
12.
go back to reference D.T. Okuda, A. Siva, O. Kantarci, M. Inglese, I. Katz, M. Tutuncu, B.M. Keegan, S. Donlon, H. Hua le, A. Vidal-Jordana, X. Montalban, A. Rovira, M. Tintoré, M.P. Amato, B. Brochet, J. de Seze, D. Brassat, P. Vermersch, N. De Stefano, M.P. Sormani, D. Pelletier, C. Lebrun, Radiologically Isolated Syndrome Consortium (RISC), Club Francophone de la Sclérose en Plaques (CFSEP) Radiologically isolated syndrome: 5-year risk for an initial clinical event. PLoS One 9, e90509 (2014) D.T. Okuda, A. Siva, O. Kantarci, M. Inglese, I. Katz, M. Tutuncu, B.M. Keegan, S. Donlon, H. Hua le, A. Vidal-Jordana, X. Montalban, A. Rovira, M. Tintoré, M.P. Amato, B. Brochet, J. de Seze, D. Brassat, P. Vermersch, N. De Stefano, M.P. Sormani, D. Pelletier, C. Lebrun, Radiologically Isolated Syndrome Consortium (RISC), Club Francophone de la Sclérose en Plaques (CFSEP) Radiologically isolated syndrome: 5-year risk for an initial clinical event. PLoS One 9, e90509 (2014)
13.
go back to reference Y. Matsumura, H. Maeda, A new concept for macromolecular therapies in cancer chemotherapy: mechanism of tumouritropic accumulation of proteins and the antitumour agent smancs. Cancer Res. 6, 6387–6392 (1986) Y. Matsumura, H. Maeda, A new concept for macromolecular therapies in cancer chemotherapy: mechanism of tumouritropic accumulation of proteins and the antitumour agent smancs. Cancer Res. 6, 6387–6392 (1986)
14.
go back to reference Y. Barenholz, Doxil®—the first FDA-approved nano-drug: lessons learned. J. Control Releas. 160, 117–134 (2012) Y. Barenholz, Doxil®—the first FDA-approved nano-drug: lessons learned. J. Control Releas. 160, 117–134 (2012)
15.
go back to reference J. Vaage, E. Barberá-Guillem, R. Abra, A. Huang, P. Working, Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts. Cancer 73, 1478–1484 (1994) J. Vaage, E. Barberá-Guillem, R. Abra, A. Huang, P. Working, Tissue distribution and therapeutic effect of intravenous free or encapsulated liposomal doxorubicin on human prostate carcinoma xenografts. Cancer 73, 1478–1484 (1994)
16.
go back to reference A. Gabizon, R. Catane, B. Uziely, B. Kaufman, T. Safra, R. Cohen, F. Martin, A. Huang, Y. Barenholz, Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 54, 987–992 (1994) A. Gabizon, R. Catane, B. Uziely, B. Kaufman, T. Safra, R. Cohen, F. Martin, A. Huang, Y. Barenholz,  Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 54, 987–992 (1994)
17.
go back to reference L.W. Seymour, D.R. Ferry, D. Anderson, S. Hesslewood, P.J. Julyan, R. Poyner, J. Doran, A.M. Young, S. Burtles, D.J. Kerr, Cancer Research Campaign Phase I/II Clinical Trials committee, Hepatic drug targeting: phase I evaluation of polymer bound doxorubicin. J. Clin. Oncol. 20, 1668–1676 (2002) L.W. Seymour, D.R. Ferry, D. Anderson, S. Hesslewood, P.J. Julyan, R. Poyner, J. Doran, A.M. Young, S. Burtles, D.J. Kerr, Cancer Research Campaign Phase I/II Clinical Trials committee, Hepatic drug targeting: phase I evaluation of polymer bound doxorubicin. J. Clin. Oncol. 20, 1668–1676 (2002)
18.
go back to reference B. Wood, R.T.P. Poon, Z. Neeman, M. Eugeni, J. Locklin, S. Dromi, S. Kachala, R. Probhakar, W. Hahne, S.K. Libutti, Phase I study of thermally sensitive liposomes containing doxorubicin (ThermoDox [TD]) given during radiofrequency ablation (RFA) in patients with unresectable hepatic malignancies. ASCO Gastrointestinal Cancers Symposium (2007). abstr. 188 B. Wood, R.T.P. Poon, Z. Neeman, M. Eugeni, J. Locklin, S. Dromi, S. Kachala, R. Probhakar, W. Hahne, S.K. Libutti, Phase I study of thermally sensitive liposomes containing doxorubicin (ThermoDox [TD]) given during radiofrequency ablation (RFA) in patients with unresectable hepatic malignancies. ASCO Gastrointestinal Cancers Symposium (2007). abstr. 188
20.
go back to reference D. Sarker, P. Workman (2007) Pharmacodynamic biomarkers for molecular cancer therapeutics. Adv. Cancer Res. 96, 213–268 D. Sarker, P. Workman (2007) Pharmacodynamic biomarkers for molecular cancer therapeutics. Adv. Cancer Res. 96, 213–268 
21.
go back to reference S.L. Stott, C.H. Hsu, D.I. Tsukrov, M. Yu, D.T. Miyamoto, B.A. Waltman, S.M. Rothenberg, A.M. Shah, M.E. Smas, G.K. Korir, F.P. Jr Floyd, A.J. Gilman, J.B. Lord, D. Winokur, S. Springer, D. Irimia, S. Nagrath, L.V. Sequist, R.J. Lee, K.J. Isselbacher, S. Maheswaran, D.A. Haber, M. Toner, Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc. Natl. Acad. Sci. 107, 18392–18397 (2010) S.L. Stott, C.H. Hsu, D.I. Tsukrov, M. Yu, D.T. Miyamoto, B.A. Waltman, S.M. Rothenberg, A.M. Shah, M.E. Smas, G.K. Korir, F.P. Jr Floyd, A.J. Gilman, J.B. Lord, D. Winokur, S. Springer, D. Irimia, S. Nagrath, L.V. Sequist, R.J. Lee, K.J. Isselbacher, S. Maheswaran, D.A. Haber, M. Toner, Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc. Natl. Acad. Sci. 107, 18392–18397 (2010)
22.
go back to reference M.S. Muthu, S.A. Kulkarni, A. Raju, S.S. Feng, Theranostic liposomes of TPGS coating for targeted co-delivery of docetaxel and quantum dots. Biomaterials 33, 3494–3501 (2012) M.S. Muthu, S.A. Kulkarni, A. Raju, S.S. Feng, Theranostic liposomes of TPGS coating for targeted co-delivery of docetaxel and quantum dots. Biomaterials 33, 3494–3501 (2012)
23.
go back to reference G. Oberdörster, Pulmonary effects of inhaled ultrafine particles. Int. Arch. Occup. Environ. Health 74, 1–8 (2001) G. Oberdörster, Pulmonary effects of inhaled ultrafine particles. Int. Arch. Occup. Environ. Health 74, 1–8 (2001)
24.
go back to reference P. Jani, G.W. Halbert, J. Langridge, A.T. Florence, Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 42, 821–826 (1990) P. Jani, G.W. Halbert, J. Langridge, A.T. Florence, Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 42, 821–826 (1990)
25.
go back to reference J. Lademann, H. Weigmann, C. Rickmeyer, H. Barthelmes, H. Schaefer, G. Mueller, W. Sterry, Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol. Appl. Skin Physiol. 12, 247–256 (1999) J. Lademann, H. Weigmann, C. Rickmeyer, H. Barthelmes, H. Schaefer, G. Mueller, W. Sterry, Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol. Appl. Skin Physiol. 12, 247–256 (1999)
26.
go back to reference G. Oberdörster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, A. Lunts, W. Kreyling, C. Cox, Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J. Toxicol. Environ. Health A 65, 1531–1543 (2002) G. Oberdörster, Z. Sharp, V. Atudorei, A. Elder, R. Gelein, A. Lunts, W. Kreyling, C. Cox, Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J. Toxicol. Environ. Health A 65, 1531–1543 (2002)
27.
go back to reference R. Gaspar, R. Duncan, Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics. Adv. Drug Deliv. Rev. 61, 1220–1231 (2009) R. Gaspar, R. Duncan, Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics. Adv. Drug Deliv. Rev. 61, 1220–1231 (2009)
28.
go back to reference M. Eaton, Nanomedicine: industry-wise research. Nat. Mater. 6, 251–253 (2007) M. Eaton, Nanomedicine: industry-wise research. Nat. Mater. 6, 251–253 (2007)
29.
go back to reference R. Nijhara, K. Balakrishnan, Bringing nanomedicines to market: regulatory challenges, opportunities, and uncertainties. Nanomed 2, 127–136 (2006) R. Nijhara, K. Balakrishnan, Bringing nanomedicines to market: regulatory challenges, opportunities, and uncertainties. Nanomed 2, 127–136 (2006)
Metadata
Title
Nanomedicine
Authors
Eda Tahir Turanlı
Elif Everest
Copyright Year
2016
DOI
https://doi.org/10.1007/978-3-319-25340-4_23

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