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01-05-2015 | Research Paper

Nanostructured mesoporous silica: new perspectives for fighting antimicrobial resistance

Authors: Georgeta Voicu, Ionuţ Dogaru, Daniela Meliţă, Raluca Meştercă, Vera Spirescu, Eliza Stan, Eliza Tote, Laurenţiu Mogoantă, George Dan Mogoşanu, Alexandru Mihai Grumezescu, Roxana Truşcă, Eugeniu Vasile, Florin Iordache, Mariana-Carmen Chifiriuc, Alina Maria Holban

Published in: Journal of Nanoparticle Research | Issue 5/2015

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Abstract

This paper investigates the antimicrobial potential of nanostructured mesoporous silica (NMS) functionalized with essential oils (EOs) and antibiotics (ATBs). The NMS networks were obtained by the basic procedure from cetyltrimethylammonium bromide and tetraethyl orthosilicate in the form of granules with diameters ranging from 100 to 300 nm with an average pore diameter of 2.2 nm, as confirmed by the BET–TEM analyses. The Salvia officinalis (SO) and Coriandrum sativum (CS) EOs and the streptomycin and neomycin ATBs were loaded in the NMS pores. TG analysis was performed in order to estimate the amount of the entrapped volatile EOs. The results of the biological analyses revealed that NMS/SO and NMS/CS exhibited a very good antimicrobial activity to an extent comparable or even superior to the one triggered by ATB, and a good in vitro and in vivo biocompatibility. Due to their regular pores, high biocompatibility, antimicrobial activity, and capacity to stabilize the volatile EOs, the obtained NMS can be used as an efficient drug delivery system for further biomedical applications.

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Title: Nanostructured mesoporous silica: new perspectives for fighting antimicrobial resistance
Authors: Georgeta Voicu
Ionuţ Dogaru
Daniela Meliţă
Raluca Meştercă
Vera Spirescu
Eliza Stan
Eliza Tote
Laurenţiu Mogoantă
George Dan Mogoşanu
Alexandru Mihai Grumezescu
Roxana Truşcă
Eugeniu Vasile
Florin Iordache
Mariana-Carmen Chifiriuc
Alina Maria Holban
Publication date: 01-05-2015
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 5/2015
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-015-3004-7

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