Top

Published in:

2018 | OriginalPaper | Chapter

18. Narratives for Drug Design

Authors : James Bown, Alexey Goltsov

Published in: Narrating Complexity

Publisher: Springer International Publishing

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

We explore the role of narratives of complex systems in anti-cancer drug design. We set out the value of narratives relating to cancer in promoting awareness of risky behaviour and in supporting decision-making regarding treatment options. We present cancer as a dysregulated, complex system that has emergent behaviours at multiple scales, and is governed by dynamical spatio-temporal processes. We show that this system changes structure and function in response to anti-cancer drugs, and explain that these changes are sufficiently complex to impede effective drug design. We pose what narrative might offer to support the process of drug design, providing an example of work done to date that might serve as a foundation for narrating complexity. We suggest ways of using this work combined with that of others to begin to consider narrating drug design.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 340 Zeitschriften

aus folgenden Fachgebieten:

Bauwesen + Immobilien
Business IT + Informatik
Finance + Banking
Management + Führung
Marketing + Vertrieb
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

previous chapter Narrative and Cognitive Modelling: Insights from Beckett Exploring Mind’s Complexity

next chapter Time Will Tell: Narrative Expressions of Time in a Complex World

Bach B, Kerracher N, Hall KW, Carpendale S, Kennedy J, Riche N (2016) Telling stories about dynamic networks with graph comics. In: Proceedings of the 2016 CHI conference on human factors in computing systems (CHI‘16). ACM Press. doi: https://doi.org/10.1145/2858036.2858387

Behar M, Barken D, Werner SL, Hoffmann A (2013) The dynamics of signaling as a pharmacological target. Cell 155:448–461CrossRef

Bown J, Andrews PS, Deeni Y, Goltsov A, Idowu M, Polack FAC, Sampson ATS, Shovman M, Stepney S (2012) Engineering simulations for cancer systems biology. Curr Drug Targets 13(12):1560–1574CrossRef

Bown JL, Shovman M, Robertson P, Boiko A, Goltsov A, Mullen P, Harrison DJ (2017) A signaling visualization toolkit to support rational design of combination therapies and biomarker discovery: SiViT. Oncotarget 8(18):29657–29667CrossRef

Boy J, Detienne F, Fekete JD (2015) Storytelling in information visualizations: does it engage users to explore data? In: Proceedings of the 33rd annual ACM conference on human factors in computing systems. ACM Press, pp 1449–1458

Cancer Research UK (2016) http://www.cancerresearchuk.org/about-cancer/what-is-cancer. Accessed 3 Aug 16

Chandarlapaty S (2012) Negative feedback and adaptive resistance to the targeted therapy of cancer. Cancer Discov 2:311–319CrossRef

Chong CR, Jänne PA (2013) The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med 19:1389–1400CrossRef

Cooper GM (2000) The cell: a molecular approach, 2nd edn. Sinauer Associates, Sunderland, MA

Coulter A, Entwistle VA, Eccles A, Ryan S, Shepperd S, Perera R (2015) Personalised care planning for adults with chronic or long-term health conditions. Cochrane Database Syst Rev 2015(3):CD010523. https://doi.org/10.1002/14651858.CD010523.pub2CrossRef

Department of Health (2012) Long term conditions compendium of information, 3rd edn. https://www.gov.uk/government/publications/long-term-conditions-compendium-of-information-third-edition. Accessed 3 Aug 2016

Goltsov A, Faratian D, Langdon SP, Mullen P, Harrison DJ, Bown J (2012) Features of the reversible sensitivity-resistance transition in PI3K/PTEN/AKT signaling network after HER2 inhibition. Cell Signal 24:493–504CrossRef

Goltsov A, Langdon SP, Goltsov G, Harrison DJ, Bown J (2014) Customizing the therapeutic response of signaling networks to promote antitumor responses by drug combinations. Front Oncol 4:13. https://doi.org/10.3389/fonc.2014.00013CrossRef

Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57–70CrossRef

Hu H, Gotlsov A, Bown JL, Sims AH, Langdon SP, Harrison DJ, Faratian D (2013) Feedforward and feedback regulation of the MAPK and PI3K oscillatory circuit in breast cancer. Cell Signal 25(1):26–32CrossRef

Jaalouk DE, Lammerding J (2009) Mechanotransduction gone awry. Nat Rev Mol Cell Biol 10:63–73. https://doi.org/10.1038/nrm2597CrossRef

Janes KA, Lauffenburger DA (2013) Models of signalling networks – what cell biologists can gain from them and give to them. J Cell Sci 126:1913–1921CrossRef

Janssen E, van Osch L, de Vries Lechner L (2013) The influence of narrative risk communication on feelings of cancer risk. Br J Health Psychol 18:407–419. https://doi.org/10.1111/j.2044-8287.2012.02098.xCrossRef

Kholodenko BN (2015) Drug resistance resulting from kinase dimerization is rationalized by thermodynamic factors describing allosteric inhibitor effects. Cell Rep 12:1939–1949. https://doi.org/10.1016/j.celrep.2015.08.014CrossRef

King’s Fund (2012) Time to think differently. Long term conditions and multimorbidity. http://www.kingsfund.org.uk/time-to-think-differently/trends/disease-and-disability/long-term-conditions-multi-morbidity#morbidity. Accessed 3 Aug 2016

Kreeger PK, Lauffenburger DA (2009) Cancer systems biology: a network modeling perspective. Carciogenesis 31(1):2–8CrossRef

Lee MJ, Ye AS, Gardino AK, Heijnk AM, Sorger PK, MacBeath G, Yaffe MB (2012) Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 149:780–794CrossRef

Lee B, Riche N, Isenberg P, Carpendale S (2015) More than telling a story: a closer look at the process of transforming data into visually shared stories. IEEE Comput Graph Appl 35(5):84–90CrossRef

Medina-Franco JL, Giulianotti MA, Welmaker GS, Houghten RA (2013) Shifting from the single- to the multitarget paradigm in drug discovery. Drug Discov Today 18:495–501CrossRef

Segel E, Heer J (2010) Narrative visualization: telling stories with data. IEEE Trans Vis Comput Graph 16(6):1139–1148CrossRef

Shaffer VA, Hulsey L, Zikmund-Fisher BJ (2013) The effects of process-focused versus experience-focused narratives in a breast cancer treatment decision task. Patient Educ Couns 93(2):255–264CrossRef

Singer CF, Köstler WJ, Hudelist G (2008) Predicting the efficacy of trastuzumab-based therapy in breast cancer: current standards and future strategies. Biochim Biophys Acta 1786(2):105–113

Stepney S, Welch PH, Andrews PS, Ritson CG (eds) (2011) Proceedings of the 2011 workshop on complex systems modelling and simulation, Paris, France, Aug 2011. Luniver Press

Stewart BW, Wild CP (2014) World cancer report. WHO Press, Geneva

United Nations General Assembly (2013) https://www.idf.org/sites/default/files/UN%20Secretary%20General%20Progress%20Report%20on%20NCDs%20Dec%202013.pdf. Accessed 3 Aug 2016

Wong E, Baur B, Quader S, Huang CH (2012) Biological network motif detection: principles and practice. Brief Bioinform 13(2):202–215. https://doi.org/10.1093/bib/bbr033CrossRef

Title: Narratives for Drug Design
Authors: James Bown
Alexey Goltsov
Publisher: Springer International Publishing
Book: Narrating Complexity
Print ISBN: 978-3-319-64712-8

Electronic ISBN: 978-3-319-64714-2

Copyright Year: 2018
DOI: https://doi.org/10.1007/978-3-319-64714-2_18

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Springer Professional "Wirtschaft"

Premium Partner