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Published in:
2009 | OriginalPaper | Chapter
Oligonucleotide Microarray Probe Correction by FixedPoint ICA Algorithm
Authors : Raul Malutan, Pedro Gómez, Monica Borda
Published in: Distributed Computing, Artificial Intelligence, Bioinformatics, Soft Computing, and Ambient Assisted Living
Publisher: Springer Berlin Heidelberg
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Oligonucleotide Microarrays have become powerful tools in genetics, as they serve as parallel scanning mechanisms to detect the presence of genes using test probes. The detection of each gene depends on the multichannel differential expression of perfectly matched segments against mismatched ones. This methodology posse some interesting problems under the point of view of Genomic Signal Processing, as test probes express themselves in rather different patterns, not showing proportional expression levels for most of the segment pairs, as it would be expected. The method proposed in this paper consists in isolating gene expressions showing unexpected behavior using independent component analysis.