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Published in: Journal of Materials Science 15/2021

16-02-2021 | Materials for life sciences

One-pot synthesis of vancomycin-encapsulated ZIF-8 nanoparticles as multivalent and photocatalytic antibacterial agents for selective-killing of pathogenic gram-positive bacteria

Authors: Chunli Hao, Dairan Zhou, Jianxiang Xu, Shi Hong, Wenmei Wei, Tingting Zhao, Huabin Huang, Weijun Fang

Published in: Journal of Materials Science | Issue 15/2021

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Abstract

In recent years, antibiotic-conjugated nanoparticles have attracted great interest for use as antimicrobial agents. Unfortunately, most of antibiotic-conjugated nanocomposites are involved in a multi-step and time-consuming process. Herein, we developed a vancomycin-encapsulated ZIF-8 (VAN@ZIF-8) nanoparticles by a simple one-pot approach to combat bacteria. The prepared VAN@ZIF-8 nanoparticles have the capacity to recognize gram-positive bacteria because of the strong and specific five-hydrogen bond between the VAN and the D-alanyl-D-alanine dipeptide coming from gram-positive bacteria cell wall. Importantly, owing to the multivalent nanoparticle-bacterium interactions, the VAN-encapsulated ZIF-8 nanoparticles exhibit a higher antibacterial efficacy in gram-positive bacteria compared to the free VAN molecules. In addition, the VAN@ZIF-8 nanoparticles as photocatalysts also show a strong photoinactivation of the bacteria under light irradiation. The present study is of interest for opening up tremendous opportunities to make good use of ZIF-8 and other MOFs in applications to combat bacteria, because of their excellent antibacterial activity and facile preparation method.

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Appendix
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Metadata
Title
One-pot synthesis of vancomycin-encapsulated ZIF-8 nanoparticles as multivalent and photocatalytic antibacterial agents for selective-killing of pathogenic gram-positive bacteria
Authors
Chunli Hao
Dairan Zhou
Jianxiang Xu
Shi Hong
Wenmei Wei
Tingting Zhao
Huabin Huang
Weijun Fang
Publication date
16-02-2021
Publisher
Springer US
Published in
Journal of Materials Science / Issue 15/2021
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-021-05828-y

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