Advertisement
Published in:
2006 | OriginalPaper | Chapter
P System Models for Mechanosensitive Channels
Authors : Ioan I. Ardelean, Daniela Besozzi, Max H. Garzon, Giancarlo Mauri, Sujoy Roy
Published in: Applications of Membrane Computing
Publisher: Springer Berlin Heidelberg
Activate our intelligent search to find suitable subject content or patents.
Select sections of text to find matching patents with Artificial Intelligence. powered by
Select sections of text to find additional relevant content using AI-assisted search. powered by
The activity of mechanosensitive channels of large conductance (MscL for short) in cellular membranes is modeled within the framework of P systems. These channels are gated by changes in the pressure exerted against the membrane, which may be due to natural environmental conditions (e.g., rain falling) or to a suction applied by artificial patch clamping. In correspondence to these distinct situations, we present two models for the description of MscL activation and functioning. We present simulations
in silico
of one model and show the emergent behavior of fundamental quantitites. Finally, we discuss several topics for further extensions and development of these models.