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Cellular Automata Model for Proteomics and Its Application in Cancer Immunotherapy Read chapter Read first chapter

2018 | OriginalPaper | Chapter

PAM: Discrete 3-D Model of Tumor Dynamics in the Presence of Anti-tumor Treatment

Authors : Marta Panuszewska, Bartosz Minch, Rafał Wcisło, Witold Dzwinel

Published in: Cellular Automata

Publisher: Springer International Publishing

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Abstract

Existing computer models of cancer focus mostly on disease progression rather than its remission/recurrence caused by anti-cancer therapy. Herein, we present a discrete model of tumor evolution in 3D, based on the Particle Automata Model (PAM) that allows for following the spatio-temporal dynamics of a small neoplasm (millimeters in diameter) under treatment. We confront the 3D model with its simplified 0D version. We demonstrate that the spatial factors such as the vascularization density, absent in the structureless 0D cancer models, can critically influence the results of treatment. We discuss briefly the role of computer simulations in personalized anti-cancer therapy.

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previous chapter A Novel Cellular Automata Modelling Framework for Micro-environmental Interaction and Co-invasion
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Metadata
Title
PAM: Discrete 3-D Model of Tumor Dynamics in the Presence of Anti-tumor Treatment
Authors
Marta Panuszewska
Bartosz Minch
Rafał Wcisło
Witold Dzwinel
Copyright Year
2018
Book
Cellular Automata

Print ISBN: 978-3-319-99812-1

Electronic ISBN: 978-3-319-99813-8

Copyright Year: 2018

DOI
https://doi.org/10.1007/978-3-319-99813-8_4

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